DegronMD

Uniprot ID: Q9H1U4

Source protein: Multiple epidermal growth factor-like domains protein 9

Source gene: MEGF9

Class: DEG_SPOP_SBC_1

Location: 353:357

E3 ligase: SPOP

DEGRON score: 0.6075

ASA_SCORE: 69.82

COIL: 0.7766

CONS_SCORE: 0.931

DSS_SCORE: 0.0135

HELIX: 0.076

FCONS_SCORE: 1.3721

RIG_SCORE: 0.7346

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R348C	TCGA-D1-A16X	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	0.1944
p.R348C	TCGA-D8-A27G	BRCA	TCGA	AVTST	DEG_SPOP_SBC_1	0.1944
p.K363N	TCGA-D6-A74Q	HNSC	TCGA	AVTST	DEG_SPOP_SBC_1	0.2778
p.K363N	DO52087	HNSC	ICGC	AVTST	DEG_SPOP_SBC_1	0.2778
p.S364L	TCGA-EO-A22X	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	0.1389
p.I362V	DO6358	CLLE	ICGC	AVTST	DEG_SPOP_SBC_1	0.1944
p.S356Y	DO229036	LICA	ICGC	AVTST	DEG_SPOP_SBC_1	0.712
p.C360F	DO50713	ORCA	ICGC	AVTST	DEG_SPOP_SBC_1	0.25
p.T357I	SIDM00524	Small Cell Lung Carcinoma	GDSC	AVTST	DEG_SPOP_SBC_1	0.7078
p.T357I	ACH-000703	Lung Cancer	CCLE	AVTST	DEG_SPOP_SBC_1	0.7078
p.T357I	DMS-79	lung	COSMIC	AVTST	DEG_SPOP_SBC_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1199:1203	AVTST	SPOP	0.9994	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	252:256	AVTST	SPOP	0.7838	More...
Q15154	Pericentriolar material 1 protein	DEG_SPOP_SBC_1	791:795	AVTST	SPOP	0.996	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1539:1543	AVTST	SPOP	0.9633	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1892:1896	AVTST	SPOP	0.8213	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1790:1794	AVTST	SPOP	0.9943	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	852:856	AVTST	SPOP	0.9732	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1280:1284	AVTST	SPOP	0.9995	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10943:10947	AVTST	SPOP	0.7326	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10997:11001	AVTST	SPOP	0.6888	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11107:11111	AVTST	SPOP	0.8831	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11161:11165	AVTST	SPOP	0.9464	More...
Q9ULR3	Protein phosphatase 1H	DEG_SPOP_SBC_1	109:113	AVTST	SPOP	0.9954	More...
Q9H1U4	Multiple epidermal growth factor-like domains protein 9	DEG_SPOP_SBC_1	353:357	AVTST	SPOP	0.6075	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	253:257	AVTST	SPOP	0.7286	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons