DegronMD - Q9ULR3(PPM1H)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R122L	TCGA-92-8063	LUSC	TCGA	AVTST	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.0833
p.R122L	DO26941	LUSC	ICGC	AVTST	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.0833
p.P114T	TCGA-BF-A1PZ	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.3056
p.P114T	DO222884	COCA	ICGC	AVTST	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.3056
p.P114T	DO50279	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.3056
p.E99K	TCGA-D8-A1JA	BRCA	TCGA	AVTST	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.0556
p.E99K	DO2819	BRCA	ICGC	AVTST	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.0556
p.N115H	TCGA-DF-A2KU	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.2778
p.N115H	DO223286	UCEC	ICGC	AVTST	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.2778
p.G108R	TCGA-DM-A28A	COAD	TCGA	AVTST	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.3056
p.G108R	DO7878	COAD	ICGC	AVTST	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.3056
p.A107V	TCGA-EE-A2GS	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.2778
p.A107V	DO37465	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.2778
p.R116M	TCGA-ER-A19C	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.25
p.R116M	DO47353	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.25
p.T111S	TCGA-ZM-AA0H	TGCT	TCGA	AVTST	DEG_SPOP_SBC_1	109:113	Mutation altering degron motif	0.7116
p.N117K	DO229022	LICA	ICGC	AVTST	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.2222
p.S112L	DO220877	MELA	ICGC	AVTST	DEG_SPOP_SBC_1	109:113	Mutation altering degron motif	0.8778
p.P114S	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	AVTST	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.3056
p.P114S	ACH-002392	Lymphoma	CCLE	AVTST	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.3056
p.P114S	SC-1	haematopoietic and lymphoid tissue	COSMIC	AVTST	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.3056

Kaplan plot for PPM1H in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPM1H

UniProt ID: Q9ULR3

Entrez ID: 57460

Protein name: Protein phosphatase 1H (EC 3.1.3.16)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPM1H in