DegronMD

Uniprot ID: Q9ULR3

Source protein: Protein phosphatase 1H

Source gene: PPM1H

Class: DEG_SPOP_SBC_1

Location: 109:113

E3 ligase: SPOP

DEGRON score: 0.9954

ASA_SCORE: 69.82

COIL: 0.7936

CONS_SCORE: 0.2932

DSS_SCORE: 0.5942

HELIX: 0.0246

FCONS_SCORE: 0.8974

RIG_SCORE: 0.6594

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R122L	TCGA-92-8063	LUSC	TCGA	AVTST	DEG_SPOP_SBC_1	0.0833
p.R122L	DO26941	LUSC	ICGC	AVTST	DEG_SPOP_SBC_1	0.0833
p.P114T	TCGA-BF-A1PZ	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	0.3056
p.P114T	DO222884	COCA	ICGC	AVTST	DEG_SPOP_SBC_1	0.3056
p.P114T	DO50279	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	0.3056
p.E99K	TCGA-D8-A1JA	BRCA	TCGA	AVTST	DEG_SPOP_SBC_1	0.0556
p.E99K	DO2819	BRCA	ICGC	AVTST	DEG_SPOP_SBC_1	0.0556
p.N115H	TCGA-DF-A2KU	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	0.2778
p.N115H	DO223286	UCEC	ICGC	AVTST	DEG_SPOP_SBC_1	0.2778
p.G108R	TCGA-DM-A28A	COAD	TCGA	AVTST	DEG_SPOP_SBC_1	0.3056
p.G108R	DO7878	COAD	ICGC	AVTST	DEG_SPOP_SBC_1	0.3056
p.A107V	TCGA-EE-A2GS	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	0.2778
p.A107V	DO37465	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	0.2778
p.R116M	TCGA-ER-A19C	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	0.25
p.R116M	DO47353	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	0.25
p.T111S	TCGA-ZM-AA0H	TGCT	TCGA	AVTST	DEG_SPOP_SBC_1	0.7116
p.N117K	DO229022	LICA	ICGC	AVTST	DEG_SPOP_SBC_1	0.2222
p.S112L	DO220877	MELA	ICGC	AVTST	DEG_SPOP_SBC_1	0.8778
p.P114S	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	AVTST	DEG_SPOP_SBC_1	0.3056
p.P114S	ACH-002392	Lymphoma	CCLE	AVTST	DEG_SPOP_SBC_1	0.3056
p.P114S	SC-1	haematopoietic_and_lymphoid_tissue	COSMIC	AVTST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1199:1203	AVTST	SPOP	0.9994	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	252:256	AVTST	SPOP	0.7838	More...
Q15154	Pericentriolar material 1 protein	DEG_SPOP_SBC_1	791:795	AVTST	SPOP	0.996	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1539:1543	AVTST	SPOP	0.9633	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1892:1896	AVTST	SPOP	0.8213	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1790:1794	AVTST	SPOP	0.9943	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	852:856	AVTST	SPOP	0.9732	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1280:1284	AVTST	SPOP	0.9995	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10943:10947	AVTST	SPOP	0.7326	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10997:11001	AVTST	SPOP	0.6888	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11107:11111	AVTST	SPOP	0.8831	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11161:11165	AVTST	SPOP	0.9464	More...
Q9ULR3	Protein phosphatase 1H	DEG_SPOP_SBC_1	109:113	AVTST	SPOP	0.9954	More...
Q9H1U4	Multiple epidermal growth factor-like domains protein 9	DEG_SPOP_SBC_1	353:357	AVTST	SPOP	0.6075	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	253:257	AVTST	SPOP	0.7286	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons