DegronMD - Q15154(PCM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1571C	TCGA-06-5416	GBM	TCGA	LEETPVIE	DEG_SCF_FBW7_2	1562:1569	Mutation rewiring degron network	0.2778
p.R1571C	DO10880	GBM	ICGC	LEETPVIE	DEG_SCF_FBW7_2	1562:1569	Mutation rewiring degron network	0.2778
p.Y788C	TCGA-A5-A0G2	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.25
p.Y788C	DO47817	STAD	ICGC	AVTST	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.25
p.Y788C	DO41235	UCEC	ICGC	AVTST	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.25
p.R497Q	TCGA-BK-A6W3	UCEC	TCGA	VRKRLNELR	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.7329
p.R497Q	DO229058	LICA	ICGC	VRKRLNELR	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.7329
p.R497Q	DO50076	UCEC	ICGC	VRKRLNELR	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.7329
p.S1578G	TCGA-BR-8589	STAD	TCGA	LEETPVIE	DEG_SCF_FBW7_2	1562:1569	Mutation blocking phosphorylation signal	0.5278
p.S1578G	DO47813	STAD	ICGC	LEETPVIE	DEG_SCF_FBW7_2	1562:1569	Mutation blocking phosphorylation signal	0.5278
p.E1458K	TCGA-CK-4951	COAD	TCGA	LTPSES	DEG_SCF_FBW7_1	1459:1464	Mutation rewiring degron network	0.3056
p.E1458K	DO10582	COAD	ICGC	LTPSES	DEG_SCF_FBW7_1	1459:1464	Mutation rewiring degron network	0.3056
p.T886M	TCGA-DU-6392	LGG	TCGA	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.1944
p.T886M	DO22237	LGG	ICGC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.1944
p.S1464I	TCGA-DX-A6YT	SARC	TCGA	LTPSES	DEG_SCF_FBW7_1	1459:1464	Mutation altering degron motif	0.7341
p.S1464I	DO220007	SARC	ICGC	LTPSES	DEG_SCF_FBW7_1	1459:1464	Mutation altering degron motif	0.7341
p.K885E	TCGA-E6-A1LX	UCEC	TCGA	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation substituting flanking lysine	0.3333
p.K885E	DO41020	UCEC	ICGC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation substituting flanking lysine	0.3333
p.D1470H	TCGA-Q1-A73O	CESC	TCGA	LTPSES	DEG_SCF_FBW7_1	1459:1464	Mutation rewiring degron network	0.1667
p.D1470H	DO51612	CESC	ICGC	LTPSES	DEG_SCF_FBW7_1	1459:1464	Mutation rewiring degron network	0.1667
p.I1453R	TCGA-R5-A7O7	STAD	TCGA	LTPSES	DEG_SCF_FBW7_1	1459:1464	Mutation rewiring degron network	0.1667
p.I1453R	DO222339	STAD	ICGC	LTPSES	DEG_SCF_FBW7_1	1459:1464	Mutation rewiring degron network	0.1667
p.E1463G	DO223068	ESCA	ICGC	LTPSES	DEG_SCF_FBW7_1	1459:1464	Mutation altering degron motif	0.6087
p.A1466S	DO229041	LICA	ICGC	LTPSES	DEG_SCF_FBW7_1	1459:1464	Mutation rewiring degron network	0.2778
p.W1452L	DO229009	LICA	ICGC	LTPSES	DEG_SCF_FBW7_1	1459:1464	Mutation rewiring degron network	0.1389
p.S866T	DO232832	NACA	ICGC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation blocking phosphorylation signal	0.5278
p.D870G	DO229259	THCA	ICGC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.1944
p.N494S	DO229211	THCA	ICGC	VRKRLNELR	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.2778
p.D1464N	DO219773	UCEC	ICGC	LTPSES	DEG_SCF_FBW7_1	1459:1464	Mutation altering degron motif	0.6932
p.E502D	SIDM02035	Colorectal Carcinoma	GDSC	VRKRLNELR	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.5647
p.G871V	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM01265	Plasma Cell Myeloma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM00773	Non-Cancerous	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM00454	Rhabdomyosarcoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM00393	Gastric Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM01126	Small Cell Lung Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM00087	Plasma Cell Myeloma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM00846	Cervical Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM00654	Small Cell Lung Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM00690	Head and Neck Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM00210	Ovarian Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM01112	Osteosarcoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM00878	Breast Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM00309	Mesothelioma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM01147	Gastric Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM00793	Burkitt's Lymphoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM00954	Breast Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM00863	Burkitt's Lymphoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM00774	Breast Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM00720	Mesothelioma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM00808	Burkitt's Lymphoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM01173	Rhabdomyosarcoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM00785	Acute Myeloid Leukemia	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM00628	Breast Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM01318	Hepatocellular Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM01664	Prostate Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.G871V	SIDM01254	Burkitt's Lymphoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.2222
p.P784L	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	AVTST	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1389
p.G1556S	SIDM00529	Breast Carcinoma	GDSC	LEETPVIE	DEG_SCF_FBW7_2	1562:1569	Mutation rewiring degron network	0.1667
p.P878L	SIDM00889	Cervical Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation altering degron motif	0.7582
p.P878L	ACH-001333	Cervical Cancer	CCLE	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation altering degron motif	0.7582
p.P878L	C-33-A	cervix	COSMIC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation altering degron motif	0.7582
p.T797I	SIDM00512	Non-Small Cell Lung Carcinoma	GDSC	AVTST	DEG_SPOP_SBC_1	791:795	Mutation blocking phosphorylation signal	0.7222
p.T797I	ACH-000662	Lung Cancer	CCLE	AVTST	DEG_SPOP_SBC_1	791:795	Mutation blocking phosphorylation signal	0.7222
p.T797I	COR-L23	lung	COSMIC	AVTST	DEG_SPOP_SBC_1	791:795	Mutation blocking phosphorylation signal	0.7222
p.T1558R	SIDM00085	Glioma	GDSC	LEETPVIE	DEG_SCF_FBW7_2	1562:1569	Mutation blocking phosphorylation signal	0.6667
p.T1558R	ACH-000655	Brain Cancer	CCLE	LEETPVIE	DEG_SCF_FBW7_2	1562:1569	Mutation blocking phosphorylation signal	0.6667
p.T1558R	SF268	central nervous system	COSMIC	LEETPVIE	DEG_SCF_FBW7_2	1562:1569	Mutation blocking phosphorylation signal	0.6667
p.K489R	SIDM00537	Colorectal Carcinoma	GDSC	VRKRLNELR	DEG_APCC_DBOX_1	496:504	Mutation blocking ubiquitination signal	0.5833
p.K489R	ACH-001345	Colon/Colorectal Cancer	CCLE	VRKRLNELR	DEG_APCC_DBOX_1	496:504	Mutation blocking ubiquitination signal	0.5833
p.K489R	GP5d	large intestine	COSMIC	VRKRLNELR	DEG_APCC_DBOX_1	496:504	Mutation blocking ubiquitination signal	0.5833
p.E1569G	SIDM00999	Bladder Carcinoma	GDSC	LEETPVIE	DEG_SCF_FBW7_2	1562:1569	Mutation altering degron motif	0.7199
p.E1569G	639-V	urinary tract	COSMIC	LEETPVIE	DEG_SCF_FBW7_2	1562:1569	Mutation altering degron motif	0.7199
p.E802K	SIDM00431	T-Lymphoblastic Leukemia	GDSC	AVTST	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1389
p.E802K	ACH-000918	Leukemia	CCLE	AVTST	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1389
p.E802K	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	AVTST	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1389
p.R504S	SIDM00201	Ewing's Sarcoma	GDSC	VRKRLNELR	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.6316
p.R504S	ACH-002119	Bone Cancer	CCLE	VRKRLNELR	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.6316
p.R504S	EW-7	bone	COSMIC	VRKRLNELR	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.6316
p.R882G	SIDM00381	Cervical Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.3056
p.R882G	SIDM01470	Acute Myeloid Leukemia	GDSC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.3056
p.R882G	ACH-000387	Leukemia	CCLE	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.3056
p.R882G	ACH-001518	Endometrial/Uterine Cancer	CCLE	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.3056
p.R882G	ACH-002020	Cervical Cancer	CCLE	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.3056
p.E1561G	ACH-000973	Bladder Cancer	CCLE	LEETPVIE	DEG_SCF_FBW7_2	1562:1569	Mutation rewiring degron network	0.3056
p.E1561G	639-V	urinary tract	COSMIC	LEETPVIE	DEG_SCF_FBW7_2	1562:1569	Mutation rewiring degron network	0.3056
p.T513A	ACH-000982	Colon/Colorectal Cancer	CCLE	VRKRLNELR	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.0833
p.G781A	ACH-001130	Lymphoma	CCLE	AVTST	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.0556
p.N874T	ACH-001991	Primary	CCLE	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation rewiring degron network	0.3056
p.P1558S	ACH-002055	Lymphoma	CCLE	LEETPVIE	DEG_SCF_FBW7_2	1562:1569	Mutation blocking phosphorylation signal	0.6667
p.M1558I	COLO-783	skin	COSMIC	LEETPVIE	DEG_SCF_FBW7_2	1562:1569	Mutation blocking phosphorylation signal	0.6667
p.E803K	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	AVTST	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1111
p.T798I	COR-L23	lung	COSMIC	AVTST	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.25
p.V1460A	EN	endometrium	COSMIC	LTPSES	DEG_SCF_FBW7_1	1459:1464	Mutation altering degron motif	0.6936
p.P879L	C-33-A	cervix	COSMIC	LCTPQQS	DEG_SCF_FBW7_1	875:881	Mutation altering degron motif	0.7582
p.S502L	BC-3	haematopoietic and lymphoid tissue	COSMIC	VRKRLNELR	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.7667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCM1

UniProt ID: Q15154

Entrez ID: 5108

Protein name: Pericentriolar material 1 protein (PCM-1) (hPCM-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCM1 in