DegronMD

Uniprot ID: Q15154

Source protein: Pericentriolar material 1 protein

Source gene: PCM1

Class: DEG_SCF_FBW7_1

Location: 1459:1464

E3 ligase: FBXW7

DEGRON score: 0.9992

ASA_SCORE: 74.8833

COIL: 0.7577

CONS_SCORE: 0.7542

DSS_SCORE: 0.5596

HELIX: 0.1645

FCONS_SCORE: 1.3999

RIG_SCORE: 0.6756

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1458K	TCGA-CK-4951	COAD	TCGA	LTPSES	DEG_SCF_FBW7_1	0.3056
p.E1458K	DO10582	COAD	ICGC	LTPSES	DEG_SCF_FBW7_1	0.3056
p.S1464I	TCGA-DX-A6YT	SARC	TCGA	LTPSES	DEG_SCF_FBW7_1	0.7341
p.S1464I	DO220007	SARC	ICGC	LTPSES	DEG_SCF_FBW7_1	0.7341
p.D1470H	TCGA-Q1-A73O	CESC	TCGA	LTPSES	DEG_SCF_FBW7_1	0.1667
p.D1470H	DO51612	CESC	ICGC	LTPSES	DEG_SCF_FBW7_1	0.1667
p.I1453R	TCGA-R5-A7O7	STAD	TCGA	LTPSES	DEG_SCF_FBW7_1	0.1667
p.I1453R	DO222339	STAD	ICGC	LTPSES	DEG_SCF_FBW7_1	0.1667
p.E1463G	DO223068	ESCA	ICGC	LTPSES	DEG_SCF_FBW7_1	0.6087
p.A1466S	DO229041	LICA	ICGC	LTPSES	DEG_SCF_FBW7_1	0.2778
p.W1452L	DO229009	LICA	ICGC	LTPSES	DEG_SCF_FBW7_1	0.1389
p.D1464N	DO219773	UCEC	ICGC	LTPSES	DEG_SCF_FBW7_1	0.6932
p.V1460A	EN	endometrium	COSMIC	LTPSES	DEG_SCF_FBW7_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15154	Pericentriolar material 1 protein	DEG_SCF_FBW7_1	1459:1464	LTPSES	FBXW7	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons