DegronMD

Uniprot ID: Q15154

Source protein: Pericentriolar material 1 protein

Source gene: PCM1

Class: DEG_SCF_FBW7_2

Location: 1562:1569

E3 ligase: FBXW7

DEGRON score: 0.963

ASA_SCORE: 98.5625

COIL: 0.7773

CONS_SCORE: 0.283

DSS_SCORE: 0.5814

HELIX: 0.1524

FCONS_SCORE: 0.7922

RIG_SCORE: 0.7742

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1571C	TCGA-06-5416	GBM	TCGA	LEETPVIE	DEG_SCF_FBW7_2	0.2778
p.R1571C	DO10880	GBM	ICGC	LEETPVIE	DEG_SCF_FBW7_2	0.2778
p.S1578G	TCGA-BR-8589	STAD	TCGA	LEETPVIE	DEG_SCF_FBW7_2	0.5278
p.S1578G	DO47813	STAD	ICGC	LEETPVIE	DEG_SCF_FBW7_2	0.5278
p.G1556S	SIDM00529	Breast Carcinoma	GDSC	LEETPVIE	DEG_SCF_FBW7_2	0.1667
p.T1558R	SIDM00085	Glioma	GDSC	LEETPVIE	DEG_SCF_FBW7_2	0.6667
p.T1558R	ACH-000655	Brain Cancer	CCLE	LEETPVIE	DEG_SCF_FBW7_2	0.6667
p.T1558R	SF268	central_nervous_system	COSMIC	LEETPVIE	DEG_SCF_FBW7_2	0.6667
p.E1569G	SIDM00999	Bladder Carcinoma	GDSC	LEETPVIE	DEG_SCF_FBW7_2	0.7199
p.E1569G	639-V	urinary_tract	COSMIC	LEETPVIE	DEG_SCF_FBW7_2	0.7199
p.E1561G	ACH-000973	Bladder Cancer	CCLE	LEETPVIE	DEG_SCF_FBW7_2	0.3056
p.E1561G	639-V	urinary_tract	COSMIC	LEETPVIE	DEG_SCF_FBW7_2	0.3056
p.P1558S	ACH-002055	Lymphoma	CCLE	LEETPVIE	DEG_SCF_FBW7_2	0.6667
p.M1558I	COLO-783	skin	COSMIC	LEETPVIE	DEG_SCF_FBW7_2	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15154	Pericentriolar material 1 protein	DEG_SCF_FBW7_2	1562:1569	LEETPVIE	FBXW7	0.963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons