DegronMD

Uniprot ID: Q15154

Source protein: Pericentriolar material 1 protein

Source gene: PCM1

Class: DEG_SPOP_SBC_1

Location: 791:795

E3 ligase: SPOP

DEGRON score: 0.996

ASA_SCORE: 92.84

COIL: 0.9422

CONS_SCORE: 0.3375

DSS_SCORE: 0.5065

HELIX: 0.0266

FCONS_SCORE: 0.9113

RIG_SCORE: 0.7066

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y788C	TCGA-A5-A0G2	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	0.25
p.Y788C	DO47817	STAD	ICGC	AVTST	DEG_SPOP_SBC_1	0.25
p.Y788C	DO41235	UCEC	ICGC	AVTST	DEG_SPOP_SBC_1	0.25
p.P784L	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	AVTST	DEG_SPOP_SBC_1	0.1389
p.T797I	SIDM00512	Non-Small Cell Lung Carcinoma	GDSC	AVTST	DEG_SPOP_SBC_1	0.7222
p.T797I	ACH-000662	Lung Cancer	CCLE	AVTST	DEG_SPOP_SBC_1	0.7222
p.T797I	COR-L23	lung	COSMIC	AVTST	DEG_SPOP_SBC_1	0.7222
p.E802K	SIDM00431	T-Lymphoblastic Leukemia	GDSC	AVTST	DEG_SPOP_SBC_1	0.1389
p.E802K	ACH-000918	Leukemia	CCLE	AVTST	DEG_SPOP_SBC_1	0.1389
p.E802K	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.G781A	ACH-001130	Lymphoma	CCLE	AVTST	DEG_SPOP_SBC_1	0.0556
p.E803K	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1111
p.T798I	COR-L23	lung	COSMIC	AVTST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1199:1203	AVTST	SPOP	0.9994	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	252:256	AVTST	SPOP	0.7838	More...
Q15154	Pericentriolar material 1 protein	DEG_SPOP_SBC_1	791:795	AVTST	SPOP	0.996	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1539:1543	AVTST	SPOP	0.9633	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1892:1896	AVTST	SPOP	0.8213	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1790:1794	AVTST	SPOP	0.9943	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	852:856	AVTST	SPOP	0.9732	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1280:1284	AVTST	SPOP	0.9995	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10943:10947	AVTST	SPOP	0.7326	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10997:11001	AVTST	SPOP	0.6888	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11107:11111	AVTST	SPOP	0.8831	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11161:11165	AVTST	SPOP	0.9464	More...
Q9ULR3	Protein phosphatase 1H	DEG_SPOP_SBC_1	109:113	AVTST	SPOP	0.9954	More...
Q9H1U4	Multiple epidermal growth factor-like domains protein 9	DEG_SPOP_SBC_1	353:357	AVTST	SPOP	0.6075	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	253:257	AVTST	SPOP	0.7286	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons