DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 1892:1896

E3 ligase: SPOP

DEGRON score: 0.8213

ASA_SCORE: 83.58

COIL: 0.794

CONS_SCORE: 0.5236

DSS_SCORE: 0.5023

HELIX: 0.0134

FCONS_SCORE: 1

RIG_SCORE: 0.7334

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1889A	TCGA-22-A5C4	LUSC	TCGA	AVTST	DEG_SPOP_SBC_1	0.25
p.T1889A	DO45446	LUSC	ICGC	AVTST	DEG_SPOP_SBC_1	0.25
p.T1900P	TCGA-44-2657	LUAD	TCGA	AVTST	DEG_SPOP_SBC_1	0.2222
p.T1900P	DO25020	LUAD	ICGC	AVTST	DEG_SPOP_SBC_1	0.2222
p.P1897L	TCGA-50-5066	LUAD	TCGA	AVTST	DEG_SPOP_SBC_1	0.3056
p.P1897L	DO25040	LUAD	ICGC	AVTST	DEG_SPOP_SBC_1	0.3056
p.V1898L	TCGA-CF-A47T	BLCA	TCGA	AVTST	DEG_SPOP_SBC_1	0.2778
p.V1898L	DO44057	BLCA	ICGC	AVTST	DEG_SPOP_SBC_1	0.2778
p.S1895G	TCGA-CM-4743	COAD	TCGA	AVTST	DEG_SPOP_SBC_1	0.6993
p.S1895G	DO8103	COAD	ICGC	AVTST	DEG_SPOP_SBC_1	0.6993
p.S1905G	TCGA-DI-A1BU	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	0.0833
p.S1905G	DO42023	UCEC	ICGC	AVTST	DEG_SPOP_SBC_1	0.0833
p.L1887R	TCGA-E6-A1LX	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	0.1944
p.L1887R	DO41020	UCEC	ICGC	AVTST	DEG_SPOP_SBC_1	0.1944
p.P1897H	TCGA-EO-A22X	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	0.3056
p.P1897H	DO43907	UCEC	ICGC	AVTST	DEG_SPOP_SBC_1	0.3056
p.T1886S	DO224731	COCA	ICGC	AVTST	DEG_SPOP_SBC_1	0.1667
p.T1886S	DO224754	COCA	ICGC	AVTST	DEG_SPOP_SBC_1	0.1667
p.T1886S	TMK-1	stomach	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1667
p.T1899A	DO228531	LICA	ICGC	AVTST	DEG_SPOP_SBC_1	0.25
p.T1899A	DO228650	LICA	ICGC	AVTST	DEG_SPOP_SBC_1	0.25
p.T1899I	DO228531	LICA	ICGC	AVTST	DEG_SPOP_SBC_1	0.25
p.T1899I	DO228650	LICA	ICGC	AVTST	DEG_SPOP_SBC_1	0.25
p.V1904A	DO228828	LICA	ICGC	AVTST	DEG_SPOP_SBC_1	0.1111
p.A1902S	DO229015	LICA	ICGC	AVTST	DEG_SPOP_SBC_1	0.1667
p.S1905I	SIDM01099	Neuroblastoma	GDSC	AVTST	DEG_SPOP_SBC_1	0.0833
p.S1905I	SK-N-FI	autonomic_ganglia	COSMIC	AVTST	DEG_SPOP_SBC_1	0.0833
p.T1884S	SIDM00532	Glioma	GDSC	AVTST	DEG_SPOP_SBC_1	0.1111
p.T1884S	ACH-001125	Brain Cancer	CCLE	AVTST	DEG_SPOP_SBC_1	0.1111
p.T1884S	MOG-G-CCM	central_nervous_system	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1111
p.Q1903P	SIDM01511	Gastric Carcinoma	GDSC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	SIDM01776	Plasma Cell Myeloma	GDSC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	AM-38	central_nervous_system	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	GB-1	central_nervous_system	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	RERF-LC-Sq1	lung	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	GAK	skin	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	NMC-G1	central_nervous_system	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	RH-18	soft_tissue	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	BFTC-909	kidney	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	TE-11	oesophagus	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	TMK-1	stomach	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	RCC-ER	kidney	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	YH-13	central_nervous_system	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	SCaBER	urinary_tract	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	LK-2	lung	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	201T	lung	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	NY	bone	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	JHH-6	liver	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	CAL-85-1	breast	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	KS-1	central_nervous_system	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	KYSE-140	oesophagus	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	HTC-C3	thyroid	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	KY821	haematopoietic_and_lymphoid_tissue	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	IM-95	stomach	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	ECC10	stomach	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	SNU-61	large_intestine	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	CCK-81	large_intestine	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	OVISE	ovary	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903P	TE-12	oesophagus	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903E	BFTC-909	kidney	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903E	CAL-85-1	breast	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903E	YH-13	central_nervous_system	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903E	SNU-61	large_intestine	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903E	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903E	RH-18	soft_tissue	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903E	RERF-LC-Sq1	lung	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903E	TMK-1	stomach	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903E	IM-95	stomach	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903E	LK-2	lung	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903E	RCC-ER	kidney	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903E	TE-11	oesophagus	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903E	GB-1	central_nervous_system	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903E	ECC10	stomach	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.Q1903E	JHH-6	liver	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1389
p.T1884I	SW982	soft_tissue	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1111
p.E1883D	Sarc9371	bone	COSMIC	AVTST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1199:1203	AVTST	SPOP	0.9994	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	252:256	AVTST	SPOP	0.7838	More...
Q15154	Pericentriolar material 1 protein	DEG_SPOP_SBC_1	791:795	AVTST	SPOP	0.996	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1539:1543	AVTST	SPOP	0.9633	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1892:1896	AVTST	SPOP	0.8213	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1790:1794	AVTST	SPOP	0.9943	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	852:856	AVTST	SPOP	0.9732	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1280:1284	AVTST	SPOP	0.9995	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10943:10947	AVTST	SPOP	0.7326	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10997:11001	AVTST	SPOP	0.6888	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11107:11111	AVTST	SPOP	0.8831	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11161:11165	AVTST	SPOP	0.9464	More...
Q9ULR3	Protein phosphatase 1H	DEG_SPOP_SBC_1	109:113	AVTST	SPOP	0.9954	More...
Q9H1U4	Multiple epidermal growth factor-like domains protein 9	DEG_SPOP_SBC_1	353:357	AVTST	SPOP	0.6075	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	253:257	AVTST	SPOP	0.7286	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AVTST

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of AVTST