DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 11161:11165

E3 ligase: SPOP

DEGRON score: 0.9464

ASA_SCORE: 85.76

COIL: 0.849

CONS_SCORE: 0

DSS_SCORE: 0.351

HELIX: 0.0152

FCONS_SCORE: 0

RIG_SCORE: 0.7516

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S11173Y	TCGA-CA-6718	COAD	TCGA	AVTST	DEG_SPOP_SBC_1	0.1111
p.S11173Y	DO7801	COAD	ICGC	AVTST	DEG_SPOP_SBC_1	0.1111
p.I11172V	TCGA-CC-A7IH	LIHC	TCGA	AVTST	DEG_SPOP_SBC_1	0.1389
p.I11172V	DO52181	LIHC	ICGC	AVTST	DEG_SPOP_SBC_1	0.1389
p.M11151I	TCGA-FS-A1Z0	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	0.0556
p.M11151I	DO37431	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	0.0556
p.M11151I	SIDM00336	Melanoma	GDSC	AVTST	DEG_SPOP_SBC_1	0.0556
p.M11151I	ACH-000881	Skin Cancer	CCLE	AVTST	DEG_SPOP_SBC_1	0.0556
p.M11151I	MEL-JUSO	skin	COSMIC	AVTST	DEG_SPOP_SBC_1	0.0556
p.S11173F	TCGA-GF-A6C9	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	0.1111
p.S11173F	DO51254	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	0.1111
p.S11174F	TCGA-WE-A8ZX	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	0.0833
p.S11174F	DO51291	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	0.0833
p.T11163I	DO222800	COCA	ICGC	AVTST	DEG_SPOP_SBC_1	0.7078
p.S11154F	DO229013	COCA	ICGC	AVTST	DEG_SPOP_SBC_1	0.1389
p.M11151V	DO234188	ESAD	ICGC	AVTST	DEG_SPOP_SBC_1	0.0556
p.L11155M	DO229024	LICA	ICGC	AVTST	DEG_SPOP_SBC_1	0.1667
p.T11169I	DO220899	MELA	ICGC	AVTST	DEG_SPOP_SBC_1	0.2222
p.A11161E	DO232913	PEME	ICGC	AVTST	DEG_SPOP_SBC_1	0.7701
p.P11168L	SIDM00521	Small Cell Lung Carcinoma	GDSC	AVTST	DEG_SPOP_SBC_1	0.25
p.P11168L	ACH-000743	Lung Cancer	CCLE	AVTST	DEG_SPOP_SBC_1	0.25
p.P11168L	COR-L95	lung	COSMIC	AVTST	DEG_SPOP_SBC_1	0.25
p.T11171I	SIDM00150	Colorectal Carcinoma	GDSC	AVTST	DEG_SPOP_SBC_1	0.1667
p.T11171I	ACH-000969	Colon/Colorectal Cancer	CCLE	AVTST	DEG_SPOP_SBC_1	0.1667
p.T11171I	KM12	large_intestine	COSMIC	AVTST	DEG_SPOP_SBC_1	0.1667
p.D11175N	SIDM01640	Acute Myeloid Leukemia	GDSC	AVTST	DEG_SPOP_SBC_1	0.0556
p.D11175N	ACH-000602	Leukemia	CCLE	AVTST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1199:1203	AVTST	SPOP	0.9994	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	252:256	AVTST	SPOP	0.7838	More...
Q15154	Pericentriolar material 1 protein	DEG_SPOP_SBC_1	791:795	AVTST	SPOP	0.996	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1539:1543	AVTST	SPOP	0.9633	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1892:1896	AVTST	SPOP	0.8213	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1790:1794	AVTST	SPOP	0.9943	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	852:856	AVTST	SPOP	0.9732	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1280:1284	AVTST	SPOP	0.9995	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10943:10947	AVTST	SPOP	0.7326	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10997:11001	AVTST	SPOP	0.6888	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11107:11111	AVTST	SPOP	0.8831	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11161:11165	AVTST	SPOP	0.9464	More...
Q9ULR3	Protein phosphatase 1H	DEG_SPOP_SBC_1	109:113	AVTST	SPOP	0.9954	More...
Q9H1U4	Multiple epidermal growth factor-like domains protein 9	DEG_SPOP_SBC_1	353:357	AVTST	SPOP	0.6075	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	253:257	AVTST	SPOP	0.7286	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AVTST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of AVTST