DegronMD

Uniprot ID: Q8TCU4

Source protein: Alstrom syndrome protein 1

Source gene: ALMS1

Class: DEG_SPOP_SBC_1

Location: 852:856

E3 ligase: SPOP

DEGRON score: 0.9732

ASA_SCORE: 84.32

COIL: 0.894

CONS_SCORE: 0.2512

DSS_SCORE: 0.5889

HELIX: 0.0204

FCONS_SCORE: 0.9081

RIG_SCORE: 0.6613

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D844N	TCGA-23-1114	OV	TCGA	AVTST	DEG_SPOP_SBC_1	0.1111
p.L862V	TCGA-50-5066	LUAD	TCGA	AVTST	DEG_SPOP_SBC_1	0.1667
p.L862V	DO25040	LUAD	ICGC	AVTST	DEG_SPOP_SBC_1	0.1667
p.P850R	TCGA-95-7947	LUAD	TCGA	AVTST	DEG_SPOP_SBC_1	0.2778
p.P850R	DO26404	LUAD	ICGC	AVTST	DEG_SPOP_SBC_1	0.2778
p.S861P	TCGA-DF-A2KU	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	0.1944
p.S861P	DO223286	UCEC	ICGC	AVTST	DEG_SPOP_SBC_1	0.1944
p.S860C	TCGA-E7-A5KF	BLCA	TCGA	AVTST	DEG_SPOP_SBC_1	0.2222
p.S860C	DO44038	BLCA	ICGC	AVTST	DEG_SPOP_SBC_1	0.2222
p.G845E	TCGA-E9-A1NC	BRCA	TCGA	AVTST	DEG_SPOP_SBC_1	0.1389
p.A858V	TCGA-FI-A2D0	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	0.2778
p.A858V	DO43891	UCEC	ICGC	AVTST	DEG_SPOP_SBC_1	0.2778
p.A858V	ACH-000999	Colon/Colorectal Cancer	CCLE	AVTST	DEG_SPOP_SBC_1	0.2778
p.Q853E	DO26404	LUAD	ICGC	AVTST	DEG_SPOP_SBC_1	0.6744
p.A859V	SIDM00217	Colorectal Carcinoma	GDSC	AVTST	DEG_SPOP_SBC_1	0.25
p.A859V	SNU-1040	large_intestine	COSMIC	AVTST	DEG_SPOP_SBC_1	0.25
p.I847V	M059J	central_nervous_system	COSMIC	AVTST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1199:1203	AVTST	SPOP	0.9994	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	252:256	AVTST	SPOP	0.7838	More...
Q15154	Pericentriolar material 1 protein	DEG_SPOP_SBC_1	791:795	AVTST	SPOP	0.996	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1539:1543	AVTST	SPOP	0.9633	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1892:1896	AVTST	SPOP	0.8213	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1790:1794	AVTST	SPOP	0.9943	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	852:856	AVTST	SPOP	0.9732	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1280:1284	AVTST	SPOP	0.9995	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10943:10947	AVTST	SPOP	0.7326	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10997:11001	AVTST	SPOP	0.6888	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11107:11111	AVTST	SPOP	0.8831	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11161:11165	AVTST	SPOP	0.9464	More...
Q9ULR3	Protein phosphatase 1H	DEG_SPOP_SBC_1	109:113	AVTST	SPOP	0.9954	More...
Q9H1U4	Multiple epidermal growth factor-like domains protein 9	DEG_SPOP_SBC_1	353:357	AVTST	SPOP	0.6075	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	253:257	AVTST	SPOP	0.7286	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons