DegronMD

Uniprot ID: Q02505

Source protein: Mucin-3A

Source gene: MUC3A

Class: DEG_SPOP_SBC_1

Location: 252:256

E3 ligase: SPOP

DEGRON score: 0.7838

ASA_SCORE: 91.68

COIL: 0.921

CONS_SCORE: 0.4534

DSS_SCORE: 0.4155

HELIX: 0.0116

FCONS_SCORE: 1

RIG_SCORE: 0.7722

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P242R	TCGA-24-1474	OV	TCGA	AVTST	DEG_SPOP_SBC_1	0.0556
p.P242R	DO31919	OV	ICGC	AVTST	DEG_SPOP_SBC_1	0.0556
p.T254N	TCGA-AX-A05Z	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	0.7055
p.T254N	DO40884	UCEC	ICGC	AVTST	DEG_SPOP_SBC_1	0.7055
p.P247L	TCGA-BF-AAOX	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	0.1944
p.P247L	DO223907	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	0.1944
p.S249F	TCGA-BF-AAP0	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	0.25
p.S249F	DO219462	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	0.25
p.S257F	TCGA-D3-A2JF	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	0.3056
p.S257F	DO38153	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	0.3056
p.S257F	SIDM00140	Melanoma	GDSC	AVTST	DEG_SPOP_SBC_1	0.3056
p.S257F	ACH-000968	Skin Cancer	CCLE	AVTST	DEG_SPOP_SBC_1	0.3056
p.S257F	COLO-792	skin	COSMIC	AVTST	DEG_SPOP_SBC_1	0.3056
p.S265F	TCGA-EE-A2MU	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	0.0833
p.S265F	DO37436	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	0.0833
p.S265F	ACH-000960	Leukemia	CCLE	AVTST	DEG_SPOP_SBC_1	0.0833
p.S244P	TCGA-EO-A22R	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	0.1111
p.S244P	DO42713	UCEC	ICGC	AVTST	DEG_SPOP_SBC_1	0.1111
p.T248N	TCGA-EO-A3AY	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	0.2222
p.T248N	DO43202	UCEC	ICGC	AVTST	DEG_SPOP_SBC_1	0.2222
p.S255F	TCGA-FS-A1ZA	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	0.7982
p.S255F	DO37551	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	0.7982
p.P254S	TCGA-GN-A265	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	0.6752
p.P254S	DO37491	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	0.6752
p.P264S	TCGA-WE-AAA3	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	0.1111
p.P264S	DO229465	SKCA	ICGC	AVTST	DEG_SPOP_SBC_1	0.1111
p.P264S	DO51295	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	0.1111
p.S257A	DO229010	COCA	ICGC	AVTST	DEG_SPOP_SBC_1	0.3056
p.S257A	DO229013	COCA	ICGC	AVTST	DEG_SPOP_SBC_1	0.3056
p.S257A	DO229016	COCA	ICGC	AVTST	DEG_SPOP_SBC_1	0.3056
p.S257A	DO229003	COCA	ICGC	AVTST	DEG_SPOP_SBC_1	0.3056
p.S257A	DO229005	COCA	ICGC	AVTST	DEG_SPOP_SBC_1	0.3056
p.I252V	DO23274	LINC	ICGC	AVTST	DEG_SPOP_SBC_1	0.7076
p.S251C	DO224599	LUSC	ICGC	AVTST	DEG_SPOP_SBC_1	0.3056
p.F256S	DO232761	PBCA	ICGC	AVTST	DEG_SPOP_SBC_1	0.7982
p.T243A	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	AVTST	DEG_SPOP_SBC_1	0.0833
p.T243A	NCI-H1770	lung	COSMIC	AVTST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1199:1203	AVTST	SPOP	0.9994	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	252:256	AVTST	SPOP	0.7838	More...
Q15154	Pericentriolar material 1 protein	DEG_SPOP_SBC_1	791:795	AVTST	SPOP	0.996	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1539:1543	AVTST	SPOP	0.9633	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1892:1896	AVTST	SPOP	0.8213	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1790:1794	AVTST	SPOP	0.9943	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	852:856	AVTST	SPOP	0.9732	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1280:1284	AVTST	SPOP	0.9995	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10943:10947	AVTST	SPOP	0.7326	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10997:11001	AVTST	SPOP	0.6888	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11107:11111	AVTST	SPOP	0.8831	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11161:11165	AVTST	SPOP	0.9464	More...
Q9ULR3	Protein phosphatase 1H	DEG_SPOP_SBC_1	109:113	AVTST	SPOP	0.9954	More...
Q9H1U4	Multiple epidermal growth factor-like domains protein 9	DEG_SPOP_SBC_1	353:357	AVTST	SPOP	0.6075	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	253:257	AVTST	SPOP	0.7286	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AVTST

Degron related mutations and impact score

Drug responses associated with MUC3A mutations

All proteins holding degron of AVTST