DegronMD

Uniprot ID: Q8TCU4

Source protein: Alstrom syndrome protein 1

Source gene: ALMS1

Class: DEG_SPOP_SBC_1

Location: 1280:1284

E3 ligase: SPOP

DEGRON score: 0.9995

ASA_SCORE: 79.52

COIL: 0.8526

CONS_SCORE: 0.2738

DSS_SCORE: 0.5615

HELIX: 0.0318

FCONS_SCORE: 0.7503

RIG_SCORE: 0.7233

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1281S	TCGA-21-1075	LUSC	TCGA	AVTST	DEG_SPOP_SBC_1	0.7116
p.T1281S	DO26484	LUSC	ICGC	AVTST	DEG_SPOP_SBC_1	0.7116
p.V1280L	TCGA-55-8506	LUAD	TCGA	AVTST	DEG_SPOP_SBC_1	0.6765
p.V1280L	DO45390	LUAD	ICGC	AVTST	DEG_SPOP_SBC_1	0.6765
p.Q1273H	TCGA-E2-A108	BRCA	TCGA	AVTST	DEG_SPOP_SBC_1	0.1389
p.P1278Q	TCGA-EE-A2MM	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	0.2778
p.P1278Q	DO37770	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	0.2778
p.A1279T	DO228805	GACA	ICGC	AVTST	DEG_SPOP_SBC_1	0.3056
p.Y1288H	DO228281	MALY	ICGC	AVTST	DEG_SPOP_SBC_1	0.2222
p.S1284A	ACH-000687	Lymphoma	CCLE	AVTST	DEG_SPOP_SBC_1	0.7588

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1199:1203	AVTST	SPOP	0.9994	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	252:256	AVTST	SPOP	0.7838	More...
Q15154	Pericentriolar material 1 protein	DEG_SPOP_SBC_1	791:795	AVTST	SPOP	0.996	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1539:1543	AVTST	SPOP	0.9633	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1892:1896	AVTST	SPOP	0.8213	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1790:1794	AVTST	SPOP	0.9943	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	852:856	AVTST	SPOP	0.9732	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1280:1284	AVTST	SPOP	0.9995	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10943:10947	AVTST	SPOP	0.7326	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10997:11001	AVTST	SPOP	0.6888	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11107:11111	AVTST	SPOP	0.8831	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11161:11165	AVTST	SPOP	0.9464	More...
Q9ULR3	Protein phosphatase 1H	DEG_SPOP_SBC_1	109:113	AVTST	SPOP	0.9954	More...
Q9H1U4	Multiple epidermal growth factor-like domains protein 9	DEG_SPOP_SBC_1	353:357	AVTST	SPOP	0.6075	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	253:257	AVTST	SPOP	0.7286	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons