DegronMD - P35658(NUP214)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1829T	TCGA-22-5471	LUSC	TCGA	AATTT	DEG_SPOP_SBC_1	1824:1828	Mutation rewiring degron network	0.3056
p.T1828A	TCGA-2Y-A9H0	LIHC	TCGA	AATTT	DEG_SPOP_SBC_1	1824:1828	Mutation altering degron motif	0.7139
p.K1382M	TCGA-49-4487	LUAD	TCGA	TKTSGVPSGF	DEG_COP1_1	1363:1372	Mutation substituting flanking lysine	0.1667
p.K1382M	TCGA-49-4487	LUAD	TCGA	PVTSS	DEG_SPOP_SBC_1	1387:1391	Mutation substituting flanking lysine	0.3056
p.K1382M	TCGA-49-4487	LUAD	TCGA	ATTTS	DEG_SPOP_SBC_1	1392:1396	Mutation substituting flanking lysine	0.1667
p.K1382M	DO24780	LUAD	ICGC	TKTSGVPSGF	DEG_COP1_1	1363:1372	Mutation substituting flanking lysine	0.1667
p.K1382M	DO24780	LUAD	ICGC	PVTSS	DEG_SPOP_SBC_1	1387:1391	Mutation substituting flanking lysine	0.3056
p.K1382M	DO24780	LUAD	ICGC	ATTTS	DEG_SPOP_SBC_1	1392:1396	Mutation substituting flanking lysine	0.1667
p.I1227L	TCGA-55-6543	LUAD	TCGA	IITPTPS	DEG_SCF_FBW7_1	1227:1233	Mutation altering degron motif	0.6063
p.S526F	TCGA-56-8625	LUSC	TCGA	LAPTPAAS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.2222
p.S526F	DO45515	LUSC	ICGC	LAPTPAAS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.2222
p.L530V	TCGA-86-8674	LUAD	TCGA	LAPTPAAS	DEG_SCF_FBW7_1	530:537	Mutation altering degron motif	0.5654
p.L530V	DO25535	LUAD	ICGC	LAPTPAAS	DEG_SCF_FBW7_1	530:537	Mutation altering degron motif	0.5654
p.S506F	TCGA-97-8175	LUAD	TCGA	PPSY	ITCH	499:502	Mutation blocking phosphorylation signal	0.6667
p.S506F	DO45376	LUAD	ICGC	PPSY	ITCH	499:502	Mutation blocking phosphorylation signal	0.6667
p.P444T	TCGA-A5-A1OF	UCEC	TCGA	PTTPTSS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.25
p.P444T	DO42568	UCEC	ICGC	PTTPTSS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.25
p.P607H	TCGA-A5-A1OF	UCEC	TCGA	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.0833
p.P607H	TCGA-A5-A1OF	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.2222
p.P607H	DO42568	UCEC	ICGC	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.0833
p.P607H	DO42568	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.2222
p.G1816D	TCGA-A6-3808	COAD	TCGA	AATTT	DEG_SPOP_SBC_1	1824:1828	Mutation rewiring degron network	0.1111
p.G1816D	DO8408	COAD	ICGC	AATTT	DEG_SPOP_SBC_1	1824:1828	Mutation rewiring degron network	0.1111
p.P1400A	TCGA-AA-3864	COAD	TCGA	PVTSS	DEG_SPOP_SBC_1	1387:1391	Mutation rewiring degron network	0.0833
p.P1400A	TCGA-AA-3864	COAD	TCGA	ATTTS	DEG_SPOP_SBC_1	1392:1396	Mutation rewiring degron network	0.2222
p.P1400A	TCGA-AA-3864	COAD	TCGA	AATST	DEG_SPOP_SBC_1	1401:1405	Mutation rewiring degron network	0.3056
p.P1400A	DO8490	COAD	ICGC	PVTSS	DEG_SPOP_SBC_1	1387:1391	Mutation rewiring degron network	0.0833
p.P1400A	DO8490	COAD	ICGC	ATTTS	DEG_SPOP_SBC_1	1392:1396	Mutation rewiring degron network	0.2222
p.P1400A	DO8490	COAD	ICGC	AATST	DEG_SPOP_SBC_1	1401:1405	Mutation rewiring degron network	0.3056
p.R1578M	TCGA-AX-A064	UCEC	TCGA	TPATTGVPDA	DEG_COP1_1	1568:1577	Mutation rewiring degron network	0.3056
p.F1374C	TCGA-AX-A0J0	UCEC	TCGA	TKTSGVPSGF	DEG_COP1_1	1363:1372	Mutation rewiring degron network	0.2778
p.F1374C	DO41133	UCEC	ICGC	TKTSGVPSGF	DEG_COP1_1	1363:1372	Mutation rewiring degron network	0.2778
p.P1232L	TCGA-AX-A1CE	UCEC	TCGA	IITPTPS	DEG_SCF_FBW7_1	1227:1233	Mutation altering degron motif	0.6471
p.G549V	TCGA-BQ-5880	KIRP	TCGA	TLESTPVPSV	DEG_COP1_1	556:565	Mutation rewiring degron network	0.1389
p.G549V	TCGA-BQ-5880	KIRP	TCGA	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation rewiring degron network	0.1111
p.G549V	DO20754	KIRP	ICGC	TLESTPVPSV	DEG_COP1_1	556:565	Mutation rewiring degron network	0.1389
p.G549V	DO20754	KIRP	ICGC	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation rewiring degron network	0.1111
p.S581P	TCGA-BR-4361	STAD	TCGA	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation altering degron motif	0.7863
p.S581P	DO38887	STAD	ICGC	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation altering degron motif	0.7863
p.G1627D	TCGA-BR-4361	STAD	TCGA	ASSTT	DEG_SPOP_SBC_1	1617:1621	Mutation rewiring degron network	0.1667
p.K1195N	TCGA-C5-A8XK	CESC	TCGA	VTSTPSAS	DEG_SCF_FBW7_1	1200:1207	Mutation substituting flanking lysine	0.3056
p.K1195N	TCGA-C5-A8XK	CESC	TCGA	AVTST	DEG_SPOP_SBC_1	1199:1203	Mutation substituting flanking lysine	0.3333
p.S1307F	TCGA-C8-A1HL	BRCA	TCGA	ALSTT	DEG_SPOP_SBC_1	1302:1306	Mutation rewiring degron network	0.3056
p.S1307F	DO3952	BRCA	ICGC	ALSTT	DEG_SPOP_SBC_1	1302:1306	Mutation rewiring degron network	0.3056
p.S1307F	DO11854	GBM	ICGC	ALSTT	DEG_SPOP_SBC_1	1302:1306	Mutation rewiring degron network	0.3056
p.N1350D	TCGA-C8-A3M7	BRCA	TCGA	ASSTS	DEG_SPOP_SBC_1	1352:1356	Mutation rewiring degron network	0.2778
p.S579P	TCGA-CA-5255	COAD	TCGA	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation altering degron motif	0.6752
p.S579P	DO10052	COAD	ICGC	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation altering degron motif	0.6752
p.S521Y	TCGA-CA-6718	COAD	TCGA	LAPTPAAS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.0833
p.S521Y	DO7801	COAD	ICGC	LAPTPAAS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.0833
p.S1622P	TCGA-CG-5721	STAD	TCGA	VETSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.0833
p.S1622P	TCGA-CG-5721	STAD	TCGA	ASSTT	DEG_SPOP_SBC_1	1617:1621	Mutation rewiring degron network	0.3056
p.A1190T	TCGA-CK-4948	COAD	TCGA	VTSTPSAS	DEG_SCF_FBW7_1	1200:1207	Mutation rewiring degron network	0.0556
p.A1190T	TCGA-CK-4948	COAD	TCGA	AVTST	DEG_SPOP_SBC_1	1199:1203	Mutation rewiring degron network	0.0833
p.S1556C	TCGA-CR-7388	HNSC	TCGA	AASST	DEG_SPOP_SBC_1	1554:1558	Mutation altering degron motif	0.7541
p.L1560I	TCGA-CR-7388	HNSC	TCGA	TPATTGVPDA	DEG_COP1_1	1568:1577	Mutation rewiring degron network	0.1111
p.L1560I	TCGA-CR-7388	HNSC	TCGA	AASST	DEG_SPOP_SBC_1	1554:1558	Mutation rewiring degron network	0.2778
p.P1378S	TCGA-DA-A1IC	SKCM	TCGA	TKTSGVPSGF	DEG_COP1_1	1363:1372	Mutation rewiring degron network	0.1667
p.P1378S	TCGA-DA-A1IC	SKCM	TCGA	PVTSS	DEG_SPOP_SBC_1	1387:1391	Mutation rewiring degron network	0.0833
p.P563S	TCGA-DK-AA76	BLCA	TCGA	TLESTPVPSV	DEG_COP1_1	556:565	Mutation altering degron motif	0.6752
p.P563S	TCGA-DK-AA76	BLCA	TCGA	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation altering degron motif	0.5641
p.P563S	DO219013	BLCA	ICGC	TLESTPVPSV	DEG_COP1_1	556:565	Mutation altering degron motif	0.6752
p.P563S	DO219013	BLCA	ICGC	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation altering degron motif	0.5641
p.P1386L	TCGA-EE-A2GR	SKCM	TCGA	PVTSS	DEG_SPOP_SBC_1	1387:1391	Mutation rewiring degron network	0.3056
p.P1386L	TCGA-EE-A2GR	SKCM	TCGA	ATTTS	DEG_SPOP_SBC_1	1392:1396	Mutation rewiring degron network	0.1667
p.P577Q	TCGA-EE-A2ME	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation altering degron motif	0.7035
p.P577Q	DO38011	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation altering degron motif	0.7035
p.S1215L	TCGA-EE-A2MJ	SKCM	TCGA	VTSTPSAS	DEG_SCF_FBW7_1	1200:1207	Mutation rewiring degron network	0.1111
p.F522V	TCGA-EO-A22R	UCEC	TCGA	LAPTPAAS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.1111
p.F522V	DO42713	UCEC	ICGC	LAPTPAAS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.1111
p.S1207Y	TCGA-EO-A22U	UCEC	TCGA	VTSTPSAS	DEG_SCF_FBW7_1	1200:1207	Mutation altering degron motif	0.712
p.H1383Y	TCGA-EY-A2OQ	UCEC	TCGA	PVTSS	DEG_SPOP_SBC_1	1387:1391	Mutation rewiring degron network	0.2222
p.H1383Y	TCGA-EY-A2OQ	UCEC	TCGA	ATTTS	DEG_SPOP_SBC_1	1392:1396	Mutation rewiring degron network	0.0833
p.D507N	TCGA-FI-A2D6	UCEC	TCGA	PPSY	ITCH	499:502	Mutation rewiring degron network	0.1944
p.D507N	DO234353	ESAD	ICGC	PPSY	ITCH	499:502	Mutation rewiring degron network	0.1944
p.D507N	DO43867	UCEC	ICGC	PPSY	ITCH	499:502	Mutation rewiring degron network	0.1944
p.Q1814H	TCGA-FS-A1ZR	SKCM	TCGA	AATTT	DEG_SPOP_SBC_1	1824:1828	Mutation rewiring degron network	0.0556
p.N1350S	TCGA-FY-A3I4	THCA	TCGA	ASSTS	DEG_SPOP_SBC_1	1352:1356	Mutation rewiring degron network	0.2778
p.N1350S	DO39030	THCA	ICGC	ASSTS	DEG_SPOP_SBC_1	1352:1356	Mutation rewiring degron network	0.2778
p.G1241W	TCGA-GN-A26D	SKCM	TCGA	IITPTPS	DEG_SCF_FBW7_1	1227:1233	Mutation rewiring degron network	0.1111
p.T592A	TCGA-IB-7651	PAAD	TCGA	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.2778
p.T592A	TCGA-IB-7651	PAAD	TCGA	PVSSS	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.1389
p.T592A	DO46657	PAAD	ICGC	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.2778
p.T592A	DO46657	PAAD	ICGC	PVSSS	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.1389
p.A1646D	TCGA-IB-7651	PAAD	TCGA	AASSS	DEG_SPOP_SBC_1	1650:1654	Mutation rewiring degron network	0.2222
p.F1836L	TCGA-KL-8333	KICH	TCGA	AATTT	DEG_SPOP_SBC_1	1824:1828	Mutation rewiring degron network	0.1111
p.F520L	TCGA-QK-AA3K	HNSC	TCGA	LAPTPAAS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.0556
p.F520L	DO48446	BLCA	ICGC	LAPTPAAS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.0556
p.F520L	DO52102	HNSC	ICGC	LAPTPAAS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.0556
p.G1286E	TCGA-UY-A9PF	BLCA	TCGA	AASSS	DEG_SPOP_SBC_1	1289:1293	Mutation rewiring degron network	0.25
p.L1310M	TCGA-VQ-A8P2	STAD	TCGA	ALSTT	DEG_SPOP_SBC_1	1302:1306	Mutation rewiring degron network	0.2222
p.L1310M	DO51761	STAD	ICGC	ALSTT	DEG_SPOP_SBC_1	1302:1306	Mutation rewiring degron network	0.2222
p.S433R	TCGA-VQ-A8P8	STAD	TCGA	PTTPTSS	DEG_SCF_FBW7_1	435:441	Mutation blocking phosphorylation signal	0.7222
p.S433R	DO51764	STAD	ICGC	PTTPTSS	DEG_SCF_FBW7_1	435:441	Mutation blocking phosphorylation signal	0.7222
p.M572T	TCGA-VQ-A91E	STAD	TCGA	TLESTPVPSV	DEG_COP1_1	556:565	Mutation rewiring degron network	0.1389
p.M572T	TCGA-VQ-A91E	STAD	TCGA	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation rewiring degron network	0.1111
p.M572T	TCGA-VQ-A91E	STAD	TCGA	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1944
p.M572T	DO51784	STAD	ICGC	TLESTPVPSV	DEG_COP1_1	556:565	Mutation rewiring degron network	0.1389
p.M572T	DO51784	STAD	ICGC	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation rewiring degron network	0.1111
p.M572T	DO51784	STAD	ICGC	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1944
p.S529F	TCGA-W3-AA1R	SKCM	TCGA	LAPTPAAS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.3056
p.S529F	DO51275	SKCM	ICGC	LAPTPAAS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.3056
p.P500S	TCGA-WE-AAA0	SKCM	TCGA	PPSY	ITCH	499:502	Mutation altering degron motif	0.6752
p.P500S	DO51294	SKCM	ICGC	PPSY	ITCH	499:502	Mutation altering degron motif	0.6752
p.S1219L	TCGA-XF-AAN3	BLCA	TCGA	IITPTPS	DEG_SCF_FBW7_1	1227:1233	Mutation rewiring degron network	0.1111
p.S545L	DO48446	BLCA	ICGC	LAPTPAAS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.1111
p.S545L	SIDM00401	Melanoma	GDSC	LAPTPAAS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.1111
p.P568A	DO48446	BLCA	ICGC	TLESTPVPSV	DEG_COP1_1	556:565	Mutation rewiring degron network	0.25
p.P568A	DO48446	BLCA	ICGC	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation rewiring degron network	0.2222
p.P568A	DO48446	BLCA	ICGC	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.0833
p.S1209L	DO219053	BLCA	ICGC	VTSTPSAS	DEG_SCF_FBW7_1	1200:1207	Mutation rewiring degron network	0.2778
p.S1209L	DO219053	BLCA	ICGC	AVTST	DEG_SPOP_SBC_1	1199:1203	Mutation rewiring degron network	0.1667
p.V1414I	DO225327	BRCA	ICGC	AATST	DEG_SPOP_SBC_1	1401:1405	Mutation rewiring degron network	0.0833
p.E998K	DO222867	BTCA	ICGC	VSSTS	DEG_SPOP_SBC_1	984:988	Mutation rewiring degron network	0.0556
p.T1236A	DO229344	BTCA	ICGC	IITPTPS	DEG_SCF_FBW7_1	1227:1233	Mutation rewiring degron network	0.25
p.S658R	DO230343	COCA	ICGC	SSSPVPSM	DEG_COP1_1	655:662	Mutation altering degron motif	0.7427
p.P1304L	DO227816	COCA	ICGC	ALSTT	DEG_SPOP_SBC_1	1302:1306	Mutation altering degron motif	0.7582
p.P574S	DO229010	COCA	ICGC	TLESTPVPSV	DEG_COP1_1	556:565	Mutation rewiring degron network	0.0833
p.P574S	DO229010	COCA	ICGC	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation rewiring degron network	0.0556
p.P574S	DO229010	COCA	ICGC	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.25
p.P574S	DO229013	COCA	ICGC	TLESTPVPSV	DEG_COP1_1	556:565	Mutation rewiring degron network	0.0833
p.P574S	DO229013	COCA	ICGC	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation rewiring degron network	0.0556
p.P574S	DO229013	COCA	ICGC	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.25
p.P574S	DO229016	COCA	ICGC	TLESTPVPSV	DEG_COP1_1	556:565	Mutation rewiring degron network	0.0833
p.P574S	DO229016	COCA	ICGC	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation rewiring degron network	0.0556
p.P574S	DO229016	COCA	ICGC	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.25
p.P574S	DO229005	COCA	ICGC	TLESTPVPSV	DEG_COP1_1	556:565	Mutation rewiring degron network	0.0833
p.P574S	DO229005	COCA	ICGC	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation rewiring degron network	0.0556
p.P574S	DO229005	COCA	ICGC	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.25
p.P574S	DO228941	LICA	ICGC	TLESTPVPSV	DEG_COP1_1	556:565	Mutation rewiring degron network	0.0833
p.P574S	DO228941	LICA	ICGC	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation rewiring degron network	0.0556
p.P574S	DO228941	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.25
p.P574S	DO229028	LICA	ICGC	TLESTPVPSV	DEG_COP1_1	556:565	Mutation rewiring degron network	0.0833
p.P574S	DO229028	LICA	ICGC	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation rewiring degron network	0.0556
p.P574S	DO229028	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.25
p.P532L	DO229003	COCA	ICGC	LAPTPAAS	DEG_SCF_FBW7_1	530:537	Mutation altering degron motif	0.6471
p.P532L	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LAPTPAAS	DEG_SCF_FBW7_1	530:537	Mutation altering degron motif	0.6471
p.P532L	SIDM00581	Glioblastoma	GDSC	LAPTPAAS	DEG_SCF_FBW7_1	530:537	Mutation altering degron motif	0.6471
p.K490N	DO233913	GACA	ICGC	PPSY	ITCH	499:502	Mutation substituting flanking lysine	0.1944
p.T446I	DO233942	GACA	ICGC	PTTPTSS	DEG_SCF_FBW7_1	435:441	Mutation substituting flanking lysine	0.3056
p.I1415M	DO14284	HNSC	ICGC	AATST	DEG_SPOP_SBC_1	1401:1405	Mutation rewiring degron network	0.0556
p.F1826L	DO220341	KICH	ICGC	AATTT	DEG_SPOP_SBC_1	1824:1828	Mutation altering degron motif	0.6981
p.S491A	DO228288	LICA	ICGC	PPSY	ITCH	499:502	Mutation rewiring degron network	0.1111
p.A1303T	DO228585	LICA	ICGC	ALSTT	DEG_SPOP_SBC_1	1302:1306	Mutation altering degron motif	0.7139
p.G1750V	DO229027	LICA	ICGC	PASST	DEG_SPOP_SBC_1	1759:1763	Mutation rewiring degron network	0.0833
p.A451S	DO229026	LICA	ICGC	PTTPTSS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.0556
p.K1202N	DO229036	LICA	ICGC	VTSTPSAS	DEG_SCF_FBW7_1	1200:1207	Mutation altering degron motif	0.6918
p.K1202N	DO229036	LICA	ICGC	AVTST	DEG_SPOP_SBC_1	1199:1203	Mutation altering degron motif	0.6918
p.E1610K	DO229036	LICA	ICGC	VETSS	DEG_SPOP_SBC_1	1609:1613	Mutation altering degron motif	0.591
p.Q976H	DO229038	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	984:988	Mutation rewiring degron network	0.1111
p.S508I	DO229037	LICA	ICGC	PPSY	ITCH	499:502	Mutation blocking phosphorylation signal	0.6111
p.S997I	DO229041	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	984:988	Mutation rewiring degron network	0.0833
p.V1411F	DO229045	LICA	ICGC	AATST	DEG_SPOP_SBC_1	1401:1405	Mutation rewiring degron network	0.1667
p.T654A	DO219519	LIHC	ICGC	SSSPVPSM	DEG_COP1_1	655:662	Mutation rewiring degron network	0.3056
p.G1231V	DO23330	LINC	ICGC	IITPTPS	DEG_SCF_FBW7_1	1227:1233	Mutation altering degron motif	0.7532
p.A594T	DO48716	LIRI	ICGC	AATST	DEG_SPOP_SBC_1	594:598	Mutation altering degron motif	0.7139
p.I1217L	DO24208	LUAD	ICGC	VTSTPSAS	DEG_SCF_FBW7_1	1200:1207	Mutation rewiring degron network	0.0556
p.I1217L	DO24208	LUAD	ICGC	IITPTPS	DEG_SCF_FBW7_1	1227:1233	Mutation rewiring degron network	0.0556
p.A1819T	DO27500	LUSC	ICGC	AATTT	DEG_SPOP_SBC_1	1824:1828	Mutation rewiring degron network	0.1944
p.A600T	DO52692	MALY	ICGC	PVSSS	DEG_SPOP_SBC_1	599:603	Mutation altering degron motif	0.7139
p.S1370L	DO228885	MALY	ICGC	TKTSGVPSGF	DEG_COP1_1	1363:1372	Mutation altering degron motif	0.7667
p.G1402C	DO228880	MALY	ICGC	AATST	DEG_SPOP_SBC_1	1401:1405	Mutation altering degron motif	0.76
p.G1231W	DO37480	SKCM	ICGC	IITPTPS	DEG_SCF_FBW7_1	1227:1233	Mutation altering degron motif	0.7825
p.E1309K	DO37483	SKCM	ICGC	ALSTT	DEG_SPOP_SBC_1	1302:1306	Mutation substituting flanking lysine	0.3611
p.P1379S	DO37430	SKCM	ICGC	TKTSGVPSGF	DEG_COP1_1	1363:1372	Mutation rewiring degron network	0.1389
p.P1379S	DO37430	SKCM	ICGC	PVTSS	DEG_SPOP_SBC_1	1387:1391	Mutation rewiring degron network	0.1111
p.P1387L	DO37996	SKCM	ICGC	PVTSS	DEG_SPOP_SBC_1	1387:1391	Mutation altering degron motif	0.7582
p.S1216L	DO38099	SKCM	ICGC	VTSTPSAS	DEG_SCF_FBW7_1	1200:1207	Mutation rewiring degron network	0.0833
p.G1617D	DO38887	STAD	ICGC	ASSTT	DEG_SPOP_SBC_1	1617:1621	Mutation altering degron motif	0.7198
p.T1661M	DO51761	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	1650:1654	Mutation rewiring degron network	0.1389
p.S1612P	DO38192	STAD	ICGC	VETSS	DEG_SPOP_SBC_1	1609:1613	Mutation altering degron motif	0.6752
p.A443T	DO229216	THCA	ICGC	PTTPTSS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.2778
p.A1655T	DO43306	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	1650:1654	Mutation rewiring degron network	0.3056
p.R1579M	DO43073	UCEC	ICGC	TPATTGVPDA	DEG_COP1_1	1568:1577	Mutation rewiring degron network	0.2778
p.G1838C	DO52402	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	1824:1828	Mutation rewiring degron network	0.0556
p.A1622T	DO42881	UCEC	ICGC	VETSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.0833
p.A1622T	DO42881	UCEC	ICGC	ASSTT	DEG_SPOP_SBC_1	1617:1621	Mutation rewiring degron network	0.3056
p.S1197Y	DO43755	UCEC	ICGC	VTSTPSAS	DEG_SCF_FBW7_1	1200:1207	Mutation rewiring degron network	0.25
p.S1197Y	DO43755	UCEC	ICGC	AVTST	DEG_SPOP_SBC_1	1199:1203	Mutation rewiring degron network	0.2778
p.S1579F	DO43971	UCEC	ICGC	TPATTGVPDA	DEG_COP1_1	1568:1577	Mutation rewiring degron network	0.2778
p.T1826A	SIDM00373	Endometrial Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	1824:1828	Mutation altering degron motif	0.7139
p.T1826A	ACH-000974	Endometrial/Uterine Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	1824:1828	Mutation altering degron motif	0.7139
p.T1826A	ACH-002026	Endometrial/Uterine Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	1824:1828	Mutation altering degron motif	0.7139
p.T1826A	ACH-002710	Sarcoma	CCLE	AATTT	DEG_SPOP_SBC_1	1824:1828	Mutation altering degron motif	0.7139
p.T1826A	SNG-M	endometrium	COSMIC	AATTT	DEG_SPOP_SBC_1	1824:1828	Mutation altering degron motif	0.7139
p.T1355A	SIDM01034	B-Lymphoblastic Leukemia	GDSC	ASSTS	DEG_SPOP_SBC_1	1352:1356	Mutation altering degron motif	0.825
p.T1355A	SIDM00596	Endometrial Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1352:1356	Mutation altering degron motif	0.825
p.T1355A	SIDM00214	Colorectal Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1352:1356	Mutation altering degron motif	0.825
p.T1355A	ACH-000941	Endometrial/Uterine Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	1352:1356	Mutation altering degron motif	0.825
p.T1355A	ACH-000954	Endometrial/Uterine Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	1352:1356	Mutation altering degron motif	0.825
p.T1355A	ACH-000955	Colon/Colorectal Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	1352:1356	Mutation altering degron motif	0.825
p.T1355A	ACH-001106	Leukemia	CCLE	ASSTS	DEG_SPOP_SBC_1	1352:1356	Mutation altering degron motif	0.825
p.T1355A	ACH-001517	Endometrial/Uterine Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	1352:1356	Mutation altering degron motif	0.825
p.T1355A	SNU-407	large intestine	COSMIC	ASSTS	DEG_SPOP_SBC_1	1352:1356	Mutation altering degron motif	0.825
p.T1355A	HEC-1	endometrium	COSMIC	ASSTS	DEG_SPOP_SBC_1	1352:1356	Mutation altering degron motif	0.825
p.T1355A	KOPN-8	haematopoietic and lymphoid tissue	COSMIC	ASSTS	DEG_SPOP_SBC_1	1352:1356	Mutation altering degron motif	0.825
p.E558K	SIDM01119	Other Solid Cancers	GDSC	TLESTPVPSV	DEG_COP1_1	556:565	Mutation altering degron motif	0.591
p.E558K	SIDM01119	Other Solid Cancers	GDSC	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation altering degron motif	0.591
p.E558K	ACH-000775	Lung Cancer	CCLE	TLESTPVPSV	DEG_COP1_1	556:565	Mutation altering degron motif	0.591
p.E558K	ACH-000775	Lung Cancer	CCLE	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation altering degron motif	0.591
p.E558K	NCI-H727	lung	COSMIC	TLESTPVPSV	DEG_COP1_1	556:565	Mutation altering degron motif	0.591
p.E558K	NCI-H727	lung	COSMIC	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation altering degron motif	0.591
p.V1368M	SIDM00845	Burkitt's Lymphoma	GDSC	TKTSGVPSGF	DEG_COP1_1	1363:1372	Mutation altering degron motif	0.7208
p.T1614A	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VETSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.3056
p.T1614A	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	1617:1621	Mutation rewiring degron network	0.25
p.A1656P	SIDM00411	Pancreatic Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	1650:1654	Mutation rewiring degron network	0.2778
p.A1656P	YAPC	pancreas	COSMIC	AASSS	DEG_SPOP_SBC_1	1650:1654	Mutation rewiring degron network	0.2778
p.S610L	SIDM00781	Colorectal Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	599:603	Mutation blocking phosphorylation signal	0.5833
p.S610L	SIDM00780	Colorectal Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	599:603	Mutation blocking phosphorylation signal	0.5833
p.S610L	ACH-000967	Colon/Colorectal Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	599:603	Mutation blocking phosphorylation signal	0.5833
p.S610L	ACH-001199	Colon/Colorectal Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	599:603	Mutation blocking phosphorylation signal	0.5833
p.S610L	SNU-C2B	large intestine	COSMIC	PVSSS	DEG_SPOP_SBC_1	599:603	Mutation blocking phosphorylation signal	0.5833
p.V562M	SIDM00660	Colorectal Carcinoma	GDSC	TLESTPVPSV	DEG_COP1_1	556:565	Mutation altering degron motif	0.7208
p.V562M	SIDM00660	Colorectal Carcinoma	GDSC	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation altering degron motif	0.6097
p.V562M	ACH-000985	Colon/Colorectal Cancer	CCLE	TLESTPVPSV	DEG_COP1_1	556:565	Mutation altering degron motif	0.7208
p.V562M	ACH-000985	Colon/Colorectal Cancer	CCLE	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation altering degron motif	0.6097
p.V562M	LS-411N	large intestine	COSMIC	TLESTPVPSV	DEG_COP1_1	556:565	Mutation altering degron motif	0.7208
p.V562M	LS-411N	large intestine	COSMIC	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation altering degron motif	0.6097
p.P431S	SIDM00481	Ovarian Carcinoma	GDSC	PTTPTSS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.2222
p.P431S	SIDM00098	Mesothelioma	GDSC	PTTPTSS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.2222
p.P431S	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	PTTPTSS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.2222
p.P431S	SIDM00221	Melanoma	GDSC	PTTPTSS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.2222
p.P431S	SIDM00999	Bladder Carcinoma	GDSC	PTTPTSS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.2222
p.N586T	SIDM00227	Neuroblastoma	GDSC	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1944
p.N586T	SIDM00227	Neuroblastoma	GDSC	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.1111
p.N586T	SIDM00090	Ovarian Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1944
p.N586T	SIDM00090	Ovarian Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.1111
p.N586T	GI-ME-N	autonomic ganglia	COSMIC	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1944
p.N586T	GI-ME-N	autonomic ganglia	COSMIC	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.1111
p.N586T	OVCAR-8	ovary	COSMIC	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1944
p.N586T	OVCAR-8	ovary	COSMIC	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.1111
p.I570V	SIDM01134	Small Cell Lung Carcinoma	GDSC	TLESTPVPSV	DEG_COP1_1	556:565	Mutation rewiring degron network	0.1944
p.I570V	SIDM01134	Small Cell Lung Carcinoma	GDSC	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation rewiring degron network	0.1667
p.I570V	SIDM01134	Small Cell Lung Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1389
p.I570V	ACH-000292	Lung Cancer	CCLE	TLESTPVPSV	DEG_COP1_1	556:565	Mutation rewiring degron network	0.1944
p.I570V	ACH-000292	Lung Cancer	CCLE	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation rewiring degron network	0.1667
p.I570V	ACH-000292	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1389
p.I570V	NCI-H841	lung	COSMIC	TLESTPVPSV	DEG_COP1_1	556:565	Mutation rewiring degron network	0.1944
p.I570V	NCI-H841	lung	COSMIC	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation rewiring degron network	0.1667
p.I570V	NCI-H841	lung	COSMIC	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1389
p.G1627S	SIDM01149	Small Cell Lung Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	1617:1621	Mutation rewiring degron network	0.1667
p.G1627S	ACH-001365	Lung Cancer	CCLE	ASSTT	DEG_SPOP_SBC_1	1617:1621	Mutation rewiring degron network	0.1667
p.G1627S	NCI-H847	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	1617:1621	Mutation rewiring degron network	0.1667
p.N1350H	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1352:1356	Mutation rewiring degron network	0.2778
p.N1350H	ACH-002102	Lung Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	1352:1356	Mutation rewiring degron network	0.2778
p.N1350H	EMC-BAC-2	lung	COSMIC	ASSTS	DEG_SPOP_SBC_1	1352:1356	Mutation rewiring degron network	0.2778
p.S579L	SIDM00971	Breast Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation altering degron motif	0.7667
p.S579L	ACH-000828	Breast Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation altering degron motif	0.7667
p.S579L	ZR-75-30	breast	COSMIC	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation altering degron motif	0.7667
p.P1377L	SIDM00837	Colorectal Carcinoma	GDSC	TKTSGVPSGF	DEG_COP1_1	1363:1372	Mutation rewiring degron network	0.1944
p.P1377L	SIDM00837	Colorectal Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	1387:1391	Mutation rewiring degron network	0.0556
p.P1377L	ACH-000958	Colon/Colorectal Cancer	CCLE	TKTSGVPSGF	DEG_COP1_1	1363:1372	Mutation rewiring degron network	0.1944
p.P1377L	ACH-000958	Colon/Colorectal Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	1387:1391	Mutation rewiring degron network	0.0556
p.P1377L	SW48	large intestine	COSMIC	TKTSGVPSGF	DEG_COP1_1	1363:1372	Mutation rewiring degron network	0.1944
p.P1377L	SW48	large intestine	COSMIC	PVTSS	DEG_SPOP_SBC_1	1387:1391	Mutation rewiring degron network	0.0556
p.V1609I	SIDM00875	Breast Carcinoma	GDSC	VETSS	DEG_SPOP_SBC_1	1609:1613	Mutation altering degron motif	0.7076
p.V1609I	ACH-000624	Breast Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	1609:1613	Mutation altering degron motif	0.7076
p.V1609I	HCC1806	breast	COSMIC	VETSS	DEG_SPOP_SBC_1	1609:1613	Mutation altering degron motif	0.7076
p.P1606S	SIDM00126	Melanoma	GDSC	VETSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.25
p.P1606S	ACH-002147	Skin Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.25
p.P1606S	K2	skin	COSMIC	VETSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.25
p.S1307T	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	1302:1306	Mutation rewiring degron network	0.3056
p.S1307T	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	1302:1306	Mutation rewiring degron network	0.3056
p.A1302V	SIDM00217	Colorectal Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	1302:1306	Mutation altering degron motif	0.5825
p.A1302V	ACH-000999	Colon/Colorectal Cancer	CCLE	ALSTT	DEG_SPOP_SBC_1	1302:1306	Mutation altering degron motif	0.5825
p.A1302V	SNU-1040	large intestine	COSMIC	ALSTT	DEG_SPOP_SBC_1	1302:1306	Mutation altering degron motif	0.5825
p.T1621M	SIDM00217	Colorectal Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	1617:1621	Mutation altering degron motif	0.7423
p.T1621M	ACH-000999	Colon/Colorectal Cancer	CCLE	ASSTT	DEG_SPOP_SBC_1	1617:1621	Mutation altering degron motif	0.7423
p.T1621M	SNU-1040	large intestine	COSMIC	ASSTT	DEG_SPOP_SBC_1	1617:1621	Mutation altering degron motif	0.7423
p.T1384M	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PVTSS	DEG_SPOP_SBC_1	1387:1391	Mutation rewiring degron network	0.25
p.T1384M	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ATTTS	DEG_SPOP_SBC_1	1392:1396	Mutation rewiring degron network	0.1111
p.T1384M	ACH-001737	Leukemia	CCLE	PVTSS	DEG_SPOP_SBC_1	1387:1391	Mutation rewiring degron network	0.25
p.T1384M	ACH-001737	Leukemia	CCLE	ATTTS	DEG_SPOP_SBC_1	1392:1396	Mutation rewiring degron network	0.1111
p.T1384M	ACH-002222	Leukemia	CCLE	PVTSS	DEG_SPOP_SBC_1	1387:1391	Mutation rewiring degron network	0.25
p.T1384M	ACH-002222	Leukemia	CCLE	ATTTS	DEG_SPOP_SBC_1	1392:1396	Mutation rewiring degron network	0.1111
p.T1384M	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PVTSS	DEG_SPOP_SBC_1	1387:1391	Mutation rewiring degron network	0.25
p.T1384M	CTV-1	haematopoietic and lymphoid tissue	COSMIC	ATTTS	DEG_SPOP_SBC_1	1392:1396	Mutation rewiring degron network	0.1111
p.G1605C	SIDM00839	Colorectal Carcinoma	GDSC	VETSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.2222
p.G1605C	ACH-000950	Colon/Colorectal Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.2222
p.G1605C	LoVo	large intestine	COSMIC	VETSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.2222
p.A535V	SIDM01451	Pancreatic Carcinoma	GDSC	LAPTPAAS	DEG_SCF_FBW7_1	530:537	Mutation altering degron motif	0.5825
p.A535V	ACH-000933	Pancreatic Cancer	CCLE	LAPTPAAS	DEG_SCF_FBW7_1	530:537	Mutation altering degron motif	0.5825
p.P525S	ACH-001515	Cervical Cancer	CCLE	LAPTPAAS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.1944
p.P432S	K2	skin	COSMIC	PTTPTSS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.25
p.L1310F	NCI-H2170	lung	COSMIC	ALSTT	DEG_SPOP_SBC_1	1302:1306	Mutation rewiring degron network	0.2222
p.G1617S	NCI-H847	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	1617:1621	Mutation altering degron motif	0.6993
p.S572G	CW-2	large intestine	COSMIC	TLESTPVPSV	DEG_COP1_1	556:565	Mutation rewiring degron network	0.1389
p.S572G	CW-2	large intestine	COSMIC	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation rewiring degron network	0.1111
p.S572G	CW-2	large intestine	COSMIC	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1944
p.T652A	SNG-M	endometrium	COSMIC	SSSPVPSM	DEG_COP1_1	655:662	Mutation rewiring degron network	0.25
p.A1292V	SNU-1040	large intestine	COSMIC	AASSS	DEG_SPOP_SBC_1	1289:1293	Mutation altering degron motif	0.6936
p.T1345A	KOPN-8	haematopoietic and lymphoid tissue	COSMIC	ASSTS	DEG_SPOP_SBC_1	1352:1356	Mutation rewiring degron network	0.1389
p.T1345A	SNU-407	large intestine	COSMIC	ASSTS	DEG_SPOP_SBC_1	1352:1356	Mutation rewiring degron network	0.1389
p.T1345A	HEC-1	endometrium	COSMIC	ASSTS	DEG_SPOP_SBC_1	1352:1356	Mutation rewiring degron network	0.1389
p.P491L	HCE-4	oesophagus	COSMIC	PPSY	ITCH	499:502	Mutation rewiring degron network	0.1111
p.S599L	SNU-C2B	large intestine	COSMIC	PVSSS	DEG_SPOP_SBC_1	599:603	Mutation altering degron motif	0.7667
p.T1374M	CTV-1	haematopoietic and lymphoid tissue	COSMIC	TKTSGVPSGF	DEG_COP1_1	1363:1372	Mutation rewiring degron network	0.2778
p.F1399L	NCI-H345	lung	COSMIC	PVTSS	DEG_SPOP_SBC_1	1387:1391	Mutation rewiring degron network	0.1111
p.F1399L	NCI-H345	lung	COSMIC	ATTTS	DEG_SPOP_SBC_1	1392:1396	Mutation rewiring degron network	0.25
p.F1399L	NCI-H345	lung	COSMIC	AATST	DEG_SPOP_SBC_1	1401:1405	Mutation rewiring degron network	0.2778
p.A1646P	YAPC	pancreas	COSMIC	AASSS	DEG_SPOP_SBC_1	1650:1654	Mutation rewiring degron network	0.2222
p.T439P	DU-145	prostate	COSMIC	PTTPTSS	DEG_SCF_FBW7_1	435:441	Mutation altering degron motif	0.7031
p.D1243N	DND-41	haematopoietic and lymphoid tissue	COSMIC	IITPTPS	DEG_SCF_FBW7_1	1227:1233	Mutation rewiring degron network	0.0556
p.P1367L	SW48	large intestine	COSMIC	TKTSGVPSGF	DEG_COP1_1	1363:1372	Mutation altering degron motif	0.7582
p.Y574F	NCI-H650	lung	COSMIC	TLESTPVPSV	DEG_COP1_1	556:565	Mutation rewiring degron network	0.0833
p.Y574F	NCI-H650	lung	COSMIC	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation rewiring degron network	0.0556
p.Y574F	NCI-H650	lung	COSMIC	PPSTS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.25
p.P1415L	CML-T1	haematopoietic and lymphoid tissue	COSMIC	AATST	DEG_SPOP_SBC_1	1401:1405	Mutation rewiring degron network	0.0556
p.V552I	Hs940-T	skin	COSMIC	TLESTPVPSV	DEG_COP1_1	556:565	Mutation rewiring degron network	0.2222
p.V552I	Hs940-T	skin	COSMIC	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation rewiring degron network	0.1944
p.T1611M	SNU-1040	large intestine	COSMIC	VETSS	DEG_SPOP_SBC_1	1609:1613	Mutation altering degron motif	0.7423
p.P1581S	CML-T1	haematopoietic and lymphoid tissue	COSMIC	TPATTGVPDA	DEG_COP1_1	1568:1577	Mutation rewiring degron network	0.2222
p.G431C	LoVo	large intestine	COSMIC	PTTPTSS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.2222
p.S561L	RCC-ER	kidney	COSMIC	TLESTPVPSV	DEG_COP1_1	556:565	Mutation altering degron motif	0.7667
p.S561L	RCC-ER	kidney	COSMIC	LESTPVPS	DEG_SCF_FBW7_1	557:564	Mutation altering degron motif	0.7667
p.V435I	HCC1806	breast	COSMIC	PTTPTSS	DEG_SCF_FBW7_1	435:441	Mutation altering degron motif	0.7076
p.G611E	HT-144	skin	COSMIC	PVSSS	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.1111
p.T1816A	SNG-M	endometrium	COSMIC	AATTT	DEG_SPOP_SBC_1	1824:1828	Mutation rewiring degron network	0.1111
p.V1628I	HAL-01	haematopoietic and lymphoid tissue	COSMIC	ASSTT	DEG_SPOP_SBC_1	1617:1621	Mutation rewiring degron network	0.1389
p.V1628I	TK	haematopoietic and lymphoid tissue	COSMIC	ASSTT	DEG_SPOP_SBC_1	1617:1621	Mutation rewiring degron network	0.1389
p.V1599I	HCC1806	breast	COSMIC	VETSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.0556
p.G1236R	GI-1	central nervous system	COSMIC	IITPTPS	DEG_SCF_FBW7_1	1227:1233	Mutation rewiring degron network	0.25
p.T447M	SNU-1040	large intestine	COSMIC	PTTPTSS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NUP214

UniProt ID: P35658

Entrez ID: 8021

Protein name: Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for NUP214 in