DegronMD

Uniprot ID: P35658

Source protein: Nuclear pore complex protein Nup214

Source gene: NUP214

Class: DEG_COP1_1

Location: 556:565

E3 ligase: COP1

DEGRON score: 0.9906

ASA_SCORE: 86.78

COIL: 0.9414

CONS_SCORE: 0.3347

DSS_SCORE: 0.4296

HELIX: 0.0183

FCONS_SCORE: 1.0657

RIG_SCORE: 0.6715

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G549V	TCGA-BQ-5880	KIRP	TCGA	TLESTPVPSV	DEG_COP1_1	0.1389
p.G549V	DO20754	KIRP	ICGC	TLESTPVPSV	DEG_COP1_1	0.1389
p.P563S	TCGA-DK-AA76	BLCA	TCGA	TLESTPVPSV	DEG_COP1_1	0.6752
p.P563S	DO219013	BLCA	ICGC	TLESTPVPSV	DEG_COP1_1	0.6752
p.M572T	TCGA-VQ-A91E	STAD	TCGA	TLESTPVPSV	DEG_COP1_1	0.1389
p.M572T	DO51784	STAD	ICGC	TLESTPVPSV	DEG_COP1_1	0.1389
p.P568A	DO48446	BLCA	ICGC	TLESTPVPSV	DEG_COP1_1	0.25
p.P574S	DO229010	COCA	ICGC	TLESTPVPSV	DEG_COP1_1	0.0833
p.P574S	DO229013	COCA	ICGC	TLESTPVPSV	DEG_COP1_1	0.0833
p.P574S	DO229016	COCA	ICGC	TLESTPVPSV	DEG_COP1_1	0.0833
p.P574S	DO229005	COCA	ICGC	TLESTPVPSV	DEG_COP1_1	0.0833
p.P574S	DO228941	LICA	ICGC	TLESTPVPSV	DEG_COP1_1	0.0833
p.P574S	DO229028	LICA	ICGC	TLESTPVPSV	DEG_COP1_1	0.0833
p.E558K	SIDM01119	Other Solid Cancers	GDSC	TLESTPVPSV	DEG_COP1_1	0.591
p.E558K	ACH-000775	Lung Cancer	CCLE	TLESTPVPSV	DEG_COP1_1	0.591
p.E558K	NCI-H727	lung	COSMIC	TLESTPVPSV	DEG_COP1_1	0.591
p.V562M	SIDM00660	Colorectal Carcinoma	GDSC	TLESTPVPSV	DEG_COP1_1	0.7208
p.V562M	ACH-000985	Colon/Colorectal Cancer	CCLE	TLESTPVPSV	DEG_COP1_1	0.7208
p.V562M	LS-411N	large_intestine	COSMIC	TLESTPVPSV	DEG_COP1_1	0.7208
p.I570V	SIDM01134	Small Cell Lung Carcinoma	GDSC	TLESTPVPSV	DEG_COP1_1	0.1944
p.I570V	ACH-000292	Lung Cancer	CCLE	TLESTPVPSV	DEG_COP1_1	0.1944
p.I570V	NCI-H841	lung	COSMIC	TLESTPVPSV	DEG_COP1_1	0.1944
p.S572G	CW-2	large_intestine	COSMIC	TLESTPVPSV	DEG_COP1_1	0.1389
p.Y574F	NCI-H650	lung	COSMIC	TLESTPVPSV	DEG_COP1_1	0.0833
p.V552I	Hs940-T	skin	COSMIC	TLESTPVPSV	DEG_COP1_1	0.2222
p.S561L	RCC-ER	kidney	COSMIC	TLESTPVPSV	DEG_COP1_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_COP1_1	556:565	TLESTPVPSV	COP1	0.9906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons