DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SSSPVPSM
Uniprot ID:
P35658
Source protein:
Nuclear pore complex protein Nup214
Source gene:
NUP214
Class:
DEG_COP1_1
Location:
655:662
E3 ligase:
COP1
DEGRON score:
0.9821
ASA_SCORE:
85.3125
COIL:
0.929
CONS_SCORE:
0.3313
DSS_SCORE:
0.7339
HELIX:
0.0214
FCONS_SCORE:
0.9817
RIG_SCORE:
0.5334
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S658R
DO230343
COCA
ICGC
SSSPVPSM
DEG_COP1_1
0.7427
p.T654A
DO219519
LIHC
ICGC
SSSPVPSM
DEG_COP1_1
0.3056
p.T652A
SNG-M
endometrium
COSMIC
SSSPVPSM
DEG_COP1_1
0.25
Drug responses associated with NUP214 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SSSPVPSM
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P35658
Nuclear pore complex protein Nup214
DEG_COP1_1
655:662
SSSPVPSM
COP1
0.9821
More...