DegronMD

Uniprot ID: P35658

Source protein: Nuclear pore complex protein Nup214

Source gene: NUP214

Class: DEG_SPOP_SBC_1

Location: 577:581

E3 ligase: SPOP

DEGRON score: 0.9911

ASA_SCORE: 76.9

COIL: 0.9284

CONS_SCORE: 0.2998

DSS_SCORE: 0.3993

HELIX: 0.0414

FCONS_SCORE: 0.9883

RIG_SCORE: 0.6697

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S581P	TCGA-BR-4361	STAD	TCGA	PPSTS	DEG_SPOP_SBC_1	0.7863
p.S581P	DO38887	STAD	ICGC	PPSTS	DEG_SPOP_SBC_1	0.7863
p.S579L	SIDM00971	Breast Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.7667
p.S579L	ACH-000828	Breast Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	0.7667
p.S579L	ZR-75-30	breast	COSMIC	PPSTS	DEG_SPOP_SBC_1	0.7667
p.P577Q	TCGA-EE-A2ME	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	0.7035
p.P577Q	DO38011	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	0.7035
p.S579P	TCGA-CA-5255	COAD	TCGA	PPSTS	DEG_SPOP_SBC_1	0.6752
p.S579P	DO10052	COAD	ICGC	PPSTS	DEG_SPOP_SBC_1	0.6752
p.P574S	DO229010	COCA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.25
p.P574S	DO229013	COCA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.25
p.P574S	DO229016	COCA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.25
p.P574S	DO229005	COCA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.25
p.P574S	DO228941	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.25
p.P574S	DO229028	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.25
p.Y574F	NCI-H650	lung	COSMIC	PPSTS	DEG_SPOP_SBC_1	0.25
p.M572T	TCGA-VQ-A91E	STAD	TCGA	PPSTS	DEG_SPOP_SBC_1	0.1944
p.M572T	DO51784	STAD	ICGC	PPSTS	DEG_SPOP_SBC_1	0.1944
p.N586T	SIDM00227	Neuroblastoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.1944
p.N586T	SIDM00090	Ovarian Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.1944
p.N586T	GI-ME-N	autonomic_ganglia	COSMIC	PPSTS	DEG_SPOP_SBC_1	0.1944
p.N586T	OVCAR-8	ovary	COSMIC	PPSTS	DEG_SPOP_SBC_1	0.1944
p.S572G	CW-2	large_intestine	COSMIC	PPSTS	DEG_SPOP_SBC_1	0.1944
p.I570V	SIDM01134	Small Cell Lung Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.1389
p.I570V	ACH-000292	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	0.1389

Showing 1 to 25 of 27 entries

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Drug responses associated with NUP214 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPSTS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYQ6	Cadherin EGF LAG seven-pass G-type receptor 1	DEG_SPOP_SBC_1	906:910	PPSTS	SPOP	0.9655	More...
O75175	CCR4-NOT transcription complex subunit 3	DEG_SPOP_SBC_1	465:469	PPSTS	SPOP	0.8566	More...
Q9NS91	E3 ubiquitin-protein ligase RAD18	DEG_SPOP_SBC_1	190:194	PPSTS	SPOP	0.91	More...
Q86TM6	E3 ubiquitin-protein ligase synoviolin	DEG_SPOP_SBC_1	406:410	PPSTS	SPOP	0.9932	More...
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SPOP_SBC_1	742:746	PPSTS	SPOP	0.9525	More...
Q09472	Histone acetyltransferase p300	DEG_SPOP_SBC_1	954:958	PPSTS	SPOP	0.9959	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	419:423	PPSTS	SPOP	0.9758	More...
P16150	Leukosialin	DEG_SPOP_SBC_1	66:70	PPSTS	SPOP	0.9993	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1374:1378	PPSTS	SPOP	0.9728	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SPOP_SBC_1	765:769	PPSTS	SPOP	0.9907	More...
Q92918	Mitogen-activated protein kinase kinase kinase kinase 1	DEG_SPOP_SBC_1	442:446	PPSTS	SPOP	0.9477	More...
Q14938	Nuclear factor 1 X-type	DEG_SPOP_SBC_1	269:273	PPSTS	SPOP	0.9824	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	577:581	PPSTS	SPOP	0.9911	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	84:88	PPSTS	SPOP	0.9962	More...
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	904:908	PPSTS	SPOP	0.8193	More...
O60312	Phospholipid-transporting ATPase VA	DEG_SPOP_SBC_1	959:963	PPSTS	SPOP	0.8225	More...
Q96KW2	POM121-like protein 2	DEG_SPOP_SBC_1	130:134	PPSTS	SPOP	0.5646	More...
Q96KW2	POM121-like protein 2	DEG_SPOP_SBC_1	483:487	PPSTS	SPOP	0.9614	More...
O43526	Potassium voltage-gated channel subfamily KQT member 2	DEG_SPOP_SBC_1	713:717	PPSTS	SPOP	0.8569	More...
Q5T8I3	Protein FAM102B	DEG_SPOP_SBC_1	152:156	PPSTS	SPOP	0.978	More...
Q9BQ89	Protein FAM110A	DEG_SPOP_SBC_1	145:149	PPSTS	SPOP	0.8404	More...
Q96M27	Protein PRRC1	DEG_SPOP_SBC_1	111:115	PPSTS	SPOP	0.9952	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	1755:1759	PPSTS	SPOP	0.9881	More...
Q7Z7A4	PX domain-containing protein kinase-like protein	DEG_SPOP_SBC_1	505:509	PPSTS	SPOP	0.794	More...
O94933	SLIT and NTRK-like protein 3	DEG_SPOP_SBC_1	344:348	PPSTS	SPOP	0.5069	More...

Showing 1 to 25 of 31 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSTS

Degron related mutations and impact score

Drug responses associated with NUP214 mutations

All proteins holding degron of PPSTS