DegronMD - Q9NYQ6(CELSR1)

FUNCTION: Receptor that may have an important role in cell/cell signaling during nervous system formation.

GO - Biological processes (BP): apical protein localization [GO:0045176]; cell-cell adhesion [GO:0098609]; central nervous system development [GO:0007417]; establishment of body hair planar orientation [GO:0048105]; establishment of planar polarity [GO:0001736]; establishment of planar polarity of embryonic epithelium [GO:0042249]... View more >>

GO - Molecular function (MF): calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]

GO - Cellular component (CC): integral component of membrane [GO:0016021]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S908L	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	906:910	Mutation altering degron motif	0.7667
p.S908L	ACH-000638	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	906:910	Mutation altering degron motif	0.7667
p.S908L	ACH-001563	Skin Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	906:910	Mutation altering degron motif	0.7667
p.S908L	NCI-H441	lung	COSMIC	PPSTS	DEG_SPOP_SBC_1	906:910	Mutation altering degron motif	0.7667
p.R2989S	DO229041	LICA	ICGC	GRDHLNGVA	DEG_APCC_DBOX_1	2988:2996	Mutation altering degron motif	0.7427
p.E820G	DO230971	LUSC	ICGC	DEDTGE	DEG_Kelch_Keap1_1	815:820	Mutation altering degron motif	0.7199
p.E820G	DO224630	LUSC	ICGC	DEDTGE	DEG_Kelch_Keap1_1	815:820	Mutation altering degron motif	0.7199
p.E1009G	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation altering degron motif	0.7199
p.E1009G	ACH-002221	Lymphoma	CCLE	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation altering degron motif	0.7199
p.E1009G	CTB-1	haematopoietic and lymphoid tissue	COSMIC	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation altering degron motif	0.7199
p.E820D	TCGA-FS-A1Z0	SKCM	TCGA	DEDTGE	DEG_Kelch_Keap1_1	815:820	Mutation altering degron motif	0.6758
p.E820D	DO37431	SKCM	ICGC	DEDTGE	DEG_Kelch_Keap1_1	815:820	Mutation altering degron motif	0.6758
p.P906S	TCGA-46-6026	LUSC	TCGA	PPSTS	DEG_SPOP_SBC_1	906:910	Mutation altering degron motif	0.6752
p.P906S	DO233276	GACA	ICGC	PPSTS	DEG_SPOP_SBC_1	906:910	Mutation altering degron motif	0.6752
p.P906S	DO26740	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	906:910	Mutation altering degron motif	0.6752
p.E820Q	TCGA-DK-AA71	BLCA	TCGA	DEDTGE	DEG_Kelch_Keap1_1	815:820	Mutation altering degron motif	0.6744
p.E820Q	DO219010	BLCA	ICGC	DEDTGE	DEG_Kelch_Keap1_1	815:820	Mutation altering degron motif	0.6744
p.E1009Q	SIDM00963	Breast Carcinoma	GDSC	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation altering degron motif	0.6744
p.E1009Q	ACH-000927	Breast Cancer	CCLE	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation altering degron motif	0.6744
p.E1009Q	BT-474	breast	COSMIC	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation altering degron motif	0.6744

Showing 1 to 20 of 65 entries

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Kaplan plot for CELSR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CELSR1

UniProt ID: Q9NYQ6

Entrez ID: 9620

Protein name: Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CELSR1 in