DegronMD - Q9NYQ6(CELSR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S915C	TCGA-46-6026	LUSC	TCGA	PPSTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1944
p.S915C	DO26740	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1944
p.P906S	TCGA-46-6026	LUSC	TCGA	PPSTS	DEG_SPOP_SBC_1	906:910	Mutation altering degron motif	0.6752
p.P906S	DO233276	GACA	ICGC	PPSTS	DEG_SPOP_SBC_1	906:910	Mutation altering degron motif	0.6752
p.P906S	DO26740	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	906:910	Mutation altering degron motif	0.6752
p.A822T	TCGA-BG-A222	UCEC	TCGA	DEDTGE	DEG_Kelch_Keap1_1	815:820	Mutation rewiring degron network	0.2778
p.A822T	DO42977	UCEC	ICGC	DEDTGE	DEG_Kelch_Keap1_1	815:820	Mutation rewiring degron network	0.2778
p.E1003K	TCGA-CA-6717	COAD	TCGA	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation rewiring degron network	0.3056
p.E1003K	DO8264	COAD	ICGC	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation rewiring degron network	0.3056
p.E820Q	TCGA-DK-AA71	BLCA	TCGA	DEDTGE	DEG_Kelch_Keap1_1	815:820	Mutation altering degron motif	0.6744
p.E820Q	DO219010	BLCA	ICGC	DEDTGE	DEG_Kelch_Keap1_1	815:820	Mutation altering degron motif	0.6744
p.G2984W	TCGA-EE-A2GN	SKCM	TCGA	GRDHLNGVA	DEG_APCC_DBOX_1	2988:2996	Mutation rewiring degron network	0.2222
p.G2984W	DO37896	SKCM	ICGC	GRDHLNGVA	DEG_APCC_DBOX_1	2988:2996	Mutation rewiring degron network	0.2222
p.A916T	TCGA-EO-A22T	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1667
p.A916T	DO42320	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1667
p.D815N	TCGA-FI-A2D5	UCEC	TCGA	DEDTGE	DEG_Kelch_Keap1_1	815:820	Mutation altering degron motif	0.5821
p.D815N	DO41331	UCEC	ICGC	DEDTGE	DEG_Kelch_Keap1_1	815:820	Mutation altering degron motif	0.5821
p.R2985G	TCGA-FI-A2F4	UCEC	TCGA	GRDHLNGVA	DEG_APCC_DBOX_1	2988:2996	Mutation rewiring degron network	0.25
p.R2985G	DO43434	UCEC	ICGC	GRDHLNGVA	DEG_APCC_DBOX_1	2988:2996	Mutation rewiring degron network	0.25
p.E820D	TCGA-FS-A1Z0	SKCM	TCGA	DEDTGE	DEG_Kelch_Keap1_1	815:820	Mutation altering degron motif	0.6758
p.E820D	DO37431	SKCM	ICGC	DEDTGE	DEG_Kelch_Keap1_1	815:820	Mutation altering degron motif	0.6758
p.A996V	DO223039	ESCA	ICGC	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation rewiring degron network	0.1111
p.R823C	DO233823	GACA	ICGC	DEDTGE	DEG_Kelch_Keap1_1	815:820	Mutation rewiring degron network	0.25
p.D1002E	DO228952	LICA	ICGC	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation rewiring degron network	0.2778
p.N2993K	DO229015	LICA	ICGC	GRDHLNGVA	DEG_APCC_DBOX_1	2988:2996	Mutation altering degron motif	0.5806
p.R2989S	DO229041	LICA	ICGC	GRDHLNGVA	DEG_APCC_DBOX_1	2988:2996	Mutation altering degron motif	0.7427
p.D994E	DO229041	LICA	ICGC	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation rewiring degron network	0.0556
p.Y897C	DO228906	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.0833
p.E820G	DO230971	LUSC	ICGC	DEDTGE	DEG_Kelch_Keap1_1	815:820	Mutation altering degron motif	0.7199
p.E820G	DO224630	LUSC	ICGC	DEDTGE	DEG_Kelch_Keap1_1	815:820	Mutation altering degron motif	0.7199
p.A3004T	DO220883	MELA	ICGC	GRDHLNGVA	DEG_APCC_DBOX_1	2988:2996	Mutation rewiring degron network	0.1111
p.A3004T	SIDM00596	Endometrial Carcinoma	GDSC	GRDHLNGVA	DEG_APCC_DBOX_1	2988:2996	Mutation rewiring degron network	0.1111
p.A3004T	ACH-001517	Endometrial/Uterine Cancer	CCLE	GRDHLNGVA	DEG_APCC_DBOX_1	2988:2996	Mutation rewiring degron network	0.1111
p.P2987S	DO232224	PBCA	ICGC	GRDHLNGVA	DEG_APCC_DBOX_1	2988:2996	Mutation rewiring degron network	0.3056
p.E2986K	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	GRDHLNGVA	DEG_APCC_DBOX_1	2988:2996	Mutation rewiring degron network	0.2778
p.E2986K	ACH-000562	Lung Cancer	CCLE	GRDHLNGVA	DEG_APCC_DBOX_1	2988:2996	Mutation rewiring degron network	0.2778
p.E2986K	HCC-78	lung	COSMIC	GRDHLNGVA	DEG_APCC_DBOX_1	2988:2996	Mutation rewiring degron network	0.2778
p.I824L	SIDM00545	Melanoma	GDSC	DEDTGE	DEG_Kelch_Keap1_1	815:820	Mutation rewiring degron network	0.2222
p.I824L	ACH-000987	Skin Cancer	CCLE	DEDTGE	DEG_Kelch_Keap1_1	815:820	Mutation rewiring degron network	0.2222
p.I824L	Mewo	skin	COSMIC	DEDTGE	DEG_Kelch_Keap1_1	815:820	Mutation rewiring degron network	0.2222
p.I901T	SIDM00602	Gastric Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1944
p.I901T	IM-95	stomach	COSMIC	PPSTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1944
p.V2980L	SIDM00860	Head and Neck Carcinoma	GDSC	GRDHLNGVA	DEG_APCC_DBOX_1	2988:2996	Mutation rewiring degron network	0.1111
p.V2980L	ACH-000846	Head and Neck Cancer	CCLE	GRDHLNGVA	DEG_APCC_DBOX_1	2988:2996	Mutation rewiring degron network	0.1111
p.V2980L	FADU	upper aerodigestive tract	COSMIC	GRDHLNGVA	DEG_APCC_DBOX_1	2988:2996	Mutation rewiring degron network	0.1111
p.A1019G	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation rewiring degron network	0.0556
p.A1019G	ACH-002301	Lymphoma	CCLE	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation rewiring degron network	0.0556
p.A1019G	RF-48	stomach	COSMIC	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation rewiring degron network	0.0556
p.A1019S	SIDM01100	Neuroblastoma	GDSC	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation rewiring degron network	0.0556
p.A1019S	SIDM00882	Breast Carcinoma	GDSC	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation rewiring degron network	0.0556
p.A1019S	SIDM01504	Small Cell Lung Carcinoma	GDSC	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation rewiring degron network	0.0556
p.E1009Q	SIDM00963	Breast Carcinoma	GDSC	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation altering degron motif	0.6744
p.E1009Q	ACH-000927	Breast Cancer	CCLE	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation altering degron motif	0.6744
p.E1009Q	BT-474	breast	COSMIC	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation altering degron motif	0.6744
p.S908L	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	906:910	Mutation altering degron motif	0.7667
p.S908L	ACH-000638	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	906:910	Mutation altering degron motif	0.7667
p.S908L	ACH-001563	Skin Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	906:910	Mutation altering degron motif	0.7667
p.S908L	NCI-H441	lung	COSMIC	PPSTS	DEG_SPOP_SBC_1	906:910	Mutation altering degron motif	0.7667
p.E1009G	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation altering degron motif	0.7199
p.E1009G	ACH-002221	Lymphoma	CCLE	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation altering degron motif	0.7199
p.E1009G	CTB-1	haematopoietic and lymphoid tissue	COSMIC	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation altering degron motif	0.7199
p.M998I	SIDM00150	Colorectal Carcinoma	GDSC	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation rewiring degron network	0.1667
p.M998I	ACH-000969	Colon/Colorectal Cancer	CCLE	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation rewiring degron network	0.1667
p.M998I	KM12	large intestine	COSMIC	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation rewiring degron network	0.1667
p.M998V	ACH-001735	Leukemia	CCLE	LELFVE	LIG_APCC_ABBA_1	1004:1009	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CELSR1

UniProt ID: Q9NYQ6

Entrez ID: 9620

Protein name: Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CELSR1 in