DegronMD

Uniprot ID: Q9NYQ6

Source protein: Cadherin EGF LAG seven-pass G-type receptor 1

Source gene: CELSR1

Class: LIG_APCC_ABBA_1

Location: 1004:1009

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8942

ASA_SCORE: 49.0167

COIL: 0.0315

CONS_SCORE: 0.5385

DSS_SCORE: 0.39

HELIX: 0.003

FCONS_SCORE: 0.8321

RIG_SCORE: 0.8507

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1003K	TCGA-CA-6717	COAD	TCGA	LELFVE	LIG_APCC_ABBA_1	0.3056
p.E1003K	DO8264	COAD	ICGC	LELFVE	LIG_APCC_ABBA_1	0.3056
p.A996V	DO223039	ESCA	ICGC	LELFVE	LIG_APCC_ABBA_1	0.1111
p.D1002E	DO228952	LICA	ICGC	LELFVE	LIG_APCC_ABBA_1	0.2778
p.D994E	DO229041	LICA	ICGC	LELFVE	LIG_APCC_ABBA_1	0.0556
p.A1019G	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	LELFVE	LIG_APCC_ABBA_1	0.0556
p.A1019G	ACH-002301	Lymphoma	CCLE	LELFVE	LIG_APCC_ABBA_1	0.0556
p.A1019G	RF-48	stomach	COSMIC	LELFVE	LIG_APCC_ABBA_1	0.0556
p.A1019S	SIDM01100	Neuroblastoma	GDSC	LELFVE	LIG_APCC_ABBA_1	0.0556
p.A1019S	SIDM00882	Breast Carcinoma	GDSC	LELFVE	LIG_APCC_ABBA_1	0.0556
p.A1019S	SIDM01504	Small Cell Lung Carcinoma	GDSC	LELFVE	LIG_APCC_ABBA_1	0.0556
p.E1009Q	SIDM00963	Breast Carcinoma	GDSC	LELFVE	LIG_APCC_ABBA_1	0.6744
p.E1009Q	ACH-000927	Breast Cancer	CCLE	LELFVE	LIG_APCC_ABBA_1	0.6744
p.E1009Q	BT-474	breast	COSMIC	LELFVE	LIG_APCC_ABBA_1	0.6744
p.E1009G	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	LELFVE	LIG_APCC_ABBA_1	0.7199
p.E1009G	ACH-002221	Lymphoma	CCLE	LELFVE	LIG_APCC_ABBA_1	0.7199
p.E1009G	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LELFVE	LIG_APCC_ABBA_1	0.7199
p.M998I	SIDM00150	Colorectal Carcinoma	GDSC	LELFVE	LIG_APCC_ABBA_1	0.1667
p.M998I	ACH-000969	Colon/Colorectal Cancer	CCLE	LELFVE	LIG_APCC_ABBA_1	0.1667
p.M998I	KM12	large_intestine	COSMIC	LELFVE	LIG_APCC_ABBA_1	0.1667
p.M998V	ACH-001735	Leukemia	CCLE	LELFVE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYQ6	Cadherin EGF LAG seven-pass G-type receptor 1	LIG_APCC_ABBA_1	1004:1009	LELFVE	APC,CDC20,FZR1	0.8942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons