DegronMD

Uniprot ID: Q9NYQ6

Source protein: Cadherin EGF LAG seven-pass G-type receptor 1

Source gene: CELSR1

Class: DEG_Kelch_Keap1_1

Location: 815:820

E3 ligase: KEAP1

DEGRON score: 0.785

ASA_SCORE: 64.0167

COIL: 0.6713

CONS_SCORE: 0.6336

DSS_SCORE: 0.4384

HELIX: 0.0365

FCONS_SCORE: 1.0677

RIG_SCORE: 0.718

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A822T	TCGA-BG-A222	UCEC	TCGA	DEDTGE	DEG_Kelch_Keap1_1	0.2778
p.A822T	DO42977	UCEC	ICGC	DEDTGE	DEG_Kelch_Keap1_1	0.2778
p.E820Q	TCGA-DK-AA71	BLCA	TCGA	DEDTGE	DEG_Kelch_Keap1_1	0.6744
p.E820Q	DO219010	BLCA	ICGC	DEDTGE	DEG_Kelch_Keap1_1	0.6744
p.D815N	TCGA-FI-A2D5	UCEC	TCGA	DEDTGE	DEG_Kelch_Keap1_1	0.5821
p.D815N	DO41331	UCEC	ICGC	DEDTGE	DEG_Kelch_Keap1_1	0.5821
p.E820D	TCGA-FS-A1Z0	SKCM	TCGA	DEDTGE	DEG_Kelch_Keap1_1	0.6758
p.E820D	DO37431	SKCM	ICGC	DEDTGE	DEG_Kelch_Keap1_1	0.6758
p.R823C	DO233823	GACA	ICGC	DEDTGE	DEG_Kelch_Keap1_1	0.25
p.E820G	DO230971	LUSC	ICGC	DEDTGE	DEG_Kelch_Keap1_1	0.7199
p.E820G	DO224630	LUSC	ICGC	DEDTGE	DEG_Kelch_Keap1_1	0.7199
p.I824L	SIDM00545	Melanoma	GDSC	DEDTGE	DEG_Kelch_Keap1_1	0.2222
p.I824L	ACH-000987	Skin Cancer	CCLE	DEDTGE	DEG_Kelch_Keap1_1	0.2222
p.I824L	Mewo	skin	COSMIC	DEDTGE	DEG_Kelch_Keap1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCU4	Cadherin EGF LAG seven-pass G-type receptor 2	DEG_Kelch_Keap1_1	738:743	DEDTGE	KEAP1	0.9359	More...
Q9NYQ6	Cadherin EGF LAG seven-pass G-type receptor 1	DEG_Kelch_Keap1_1	815:820	DEDTGE	KEAP1	0.785	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons