DegronMD - Q9HCU4(CELSR2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P267S	TCGA-34-5927	LUSC	TCGA	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.3056
p.P267S	DO27731	LUSC	ICGC	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.3056
p.T276A	TCGA-43-2581	LUSC	TCGA	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.6028
p.T276A	DO26602	LUSC	ICGC	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.6028
p.E752K	TCGA-55-8089	LUAD	TCGA	DEDTGE	DEG_Kelch_Keap1_1	738:743	Mutation rewiring degron network	0.0833
p.E752K	DO23690	LUAD	ICGC	DEDTGE	DEG_Kelch_Keap1_1	738:743	Mutation rewiring degron network	0.0833
p.G1752C	TCGA-55-A4DF	LUAD	TCGA	FRGCLQGVR	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1667
p.G1752C	DO45318	LUAD	ICGC	FRGCLQGVR	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1667
p.A261T	TCGA-A5-A0G2	UCEC	TCGA	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1389
p.A261T	DO41235	UCEC	ICGC	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1389
p.R746H	TCGA-AD-6889	COAD	TCGA	DEDTGE	DEG_Kelch_Keap1_1	738:743	Mutation rewiring degron network	0.25
p.R746H	DO8858	COAD	ICGC	DEDTGE	DEG_Kelch_Keap1_1	738:743	Mutation rewiring degron network	0.25
p.R746H	DO8463	COAD	ICGC	DEDTGE	DEG_Kelch_Keap1_1	738:743	Mutation rewiring degron network	0.25
p.G728D	TCGA-BG-A222	UCEC	TCGA	DEDTGE	DEG_Kelch_Keap1_1	738:743	Mutation rewiring degron network	0.0556
p.G728D	DO42977	UCEC	ICGC	DEDTGE	DEG_Kelch_Keap1_1	738:743	Mutation rewiring degron network	0.0556
p.S934N	TCGA-BR-8078	STAD	TCGA	FDVFVE	LIG_APCC_ABBA_1	926:931	Mutation rewiring degron network	0.25
p.S934N	DO38288	STAD	ICGC	FDVFVE	LIG_APCC_ABBA_1	926:931	Mutation rewiring degron network	0.25
p.G1752S	TCGA-C4-A0F1	BLCA	TCGA	FRGCLQGVR	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1667
p.G1752S	TCGA-VQ-A91D	STAD	TCGA	FRGCLQGVR	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1667
p.G1752S	DO581	BLCA	ICGC	FRGCLQGVR	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1667
p.G1752S	DO51783	STAD	ICGC	FRGCLQGVR	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1667
p.S1078F	TCGA-CE-A483	THCA	TCGA	NASTGE	DEG_Kelch_Keap1_1	1076:1081	Mutation altering degron motif	0.7982
p.S1078F	DO38929	THCA	ICGC	NASTGE	DEG_Kelch_Keap1_1	1076:1081	Mutation altering degron motif	0.7982
p.R379W	TCGA-D1-A0ZQ	UCEC	TCGA	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation altering degron motif	0.7523
p.R379W	DO41879	UCEC	ICGC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation altering degron motif	0.7523
p.E743D	TCGA-D1-A1NZ	UCEC	TCGA	DEDTGE	DEG_Kelch_Keap1_1	738:743	Mutation altering degron motif	0.6758
p.E743D	DO41536	UCEC	ICGC	DEDTGE	DEG_Kelch_Keap1_1	738:743	Mutation altering degron motif	0.6758
p.S735G	TCGA-D8-A1XQ	BRCA	TCGA	DEDTGE	DEG_Kelch_Keap1_1	738:743	Mutation rewiring degron network	0.25
p.S735G	DO3095	BRCA	ICGC	DEDTGE	DEG_Kelch_Keap1_1	738:743	Mutation rewiring degron network	0.25
p.L1088P	TCGA-DI-A1BU	UCEC	TCGA	NASTGE	DEG_Kelch_Keap1_1	1076:1081	Mutation rewiring degron network	0.1389
p.L1088P	DO42023	UCEC	ICGC	NASTGE	DEG_Kelch_Keap1_1	1076:1081	Mutation rewiring degron network	0.1389
p.R269L	TCGA-DQ-5630	HNSC	TCGA	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.8428
p.R269L	TCGA-EY-A1G8	UCEC	TCGA	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.8428
p.R269L	DO14486	HNSC	ICGC	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.8428
p.R269L	DO43578	UCEC	ICGC	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.8428
p.S388P	TCGA-DS-A1OA	CESC	TCGA	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1667
p.S388P	DO6341	CESC	ICGC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1667
p.A261V	TCGA-DU-6392	LGG	TCGA	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1389
p.A261V	DO22237	LGG	ICGC	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1389
p.N917T	TCGA-E6-A1LX	UCEC	TCGA	FDVFVE	LIG_APCC_ABBA_1	926:931	Mutation rewiring degron network	0.0833
p.N917T	DO41020	UCEC	ICGC	FDVFVE	LIG_APCC_ABBA_1	926:931	Mutation rewiring degron network	0.0833
p.A1755D	TCGA-EE-A29D	SKCM	TCGA	FRGCLQGVR	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.25
p.A1755D	DO38123	SKCM	ICGC	FRGCLQGVR	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.25
p.P918S	TCGA-EE-A2MR	SKCM	TCGA	FDVFVE	LIG_APCC_ABBA_1	926:931	Mutation rewiring degron network	0.1111
p.P918S	DO37819	SKCM	ICGC	FDVFVE	LIG_APCC_ABBA_1	926:931	Mutation rewiring degron network	0.1111
p.E390K	TCGA-EO-A22U	UCEC	TCGA	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1111
p.E390K	DO43755	UCEC	ICGC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1111
p.R269Q	TCGA-EO-A3AV	UCEC	TCGA	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.7329
p.R269Q	DO52412	UCEC	ICGC	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.7329
p.T737M	TCGA-EY-A1GQ	UCEC	TCGA	DEDTGE	DEG_Kelch_Keap1_1	738:743	Mutation rewiring degron network	0.3056
p.T737M	DO43090	UCEC	ICGC	DEDTGE	DEG_Kelch_Keap1_1	738:743	Mutation rewiring degron network	0.3056
p.E390D	TCGA-F5-6814	READ	TCGA	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1111
p.E390D	TCGA-XK-AAIW	PRAD	TCGA	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1111
p.E390D	DO51407	PRAD	ICGC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1111
p.E390D	DO36556	READ	ICGC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1111
p.T282I	TCGA-FR-A8YC	SKCM	TCGA	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1667
p.T282I	DO50301	SKCM	ICGC	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1667
p.R746C	TCGA-QB-A6FS	SKCM	TCGA	DEDTGE	DEG_Kelch_Keap1_1	738:743	Mutation rewiring degron network	0.25
p.R746C	DO48654	SKCM	ICGC	DEDTGE	DEG_Kelch_Keap1_1	738:743	Mutation rewiring degron network	0.25
p.S388F	TCGA-XF-AAMR	BLCA	TCGA	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1667
p.S388F	DO51935	BLCA	ICGC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1667
p.T1079M	DO227996	COCA	ICGC	NASTGE	DEG_Kelch_Keap1_1	1076:1081	Mutation altering degron motif	0.7423
p.T260M	DO222884	COCA	ICGC	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1111
p.M751T	DO234239	ESAD	ICGC	DEDTGE	DEG_Kelch_Keap1_1	738:743	Mutation rewiring degron network	0.1111
p.R1766Q	DO234329	ESAD	ICGC	FRGCLQGVR	DEG_APCC_DBOX_1	1758:1766	Mutation altering degron motif	0.6218
p.R1766Q	ACH-002664	Colon/Colorectal Cancer	CCLE	FRGCLQGVR	DEG_APCC_DBOX_1	1758:1766	Mutation altering degron motif	0.6218
p.F929L	DO228732	GACA	ICGC	FDVFVE	LIG_APCC_ABBA_1	926:931	Mutation altering degron motif	0.6981
p.G265S	DO233791	GACA	ICGC	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.25
p.V940M	DO233731	GACA	ICGC	FDVFVE	LIG_APCC_ABBA_1	926:931	Mutation rewiring degron network	0.0833
p.R1066L	DO233884	GACA	ICGC	NASTGE	DEG_Kelch_Keap1_1	1076:1081	Mutation rewiring degron network	0.0556
p.R1066L	DO229018	LICA	ICGC	NASTGE	DEG_Kelch_Keap1_1	1076:1081	Mutation rewiring degron network	0.0556
p.A384S	DO229489	LAML	ICGC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM00630	Breast Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM01040	Ovarian Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM00362	Burkitt's Lymphoma	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM01005	Acute Myeloid Leukemia	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM00193	Colorectal Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM00057	Neuroblastoma	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM00589	Oral Cavity Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM00552	Rhabdomyosarcoma	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM01196	Hepatocellular Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM00301	Pancreatic Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM00282	Colorectal Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM00562	Breast Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM01172	Acute Myeloid Leukemia	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM00587	Biliary Tract Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM00251	Gastric Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM00397	Acute Myeloid Leukemia	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM01660	Kidney Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM01377	Ovarian Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM01763	Rhabdomyosarcoma	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.A384S	SIDM00162	Biliary Tract Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.E1772V	DO231984	LICA	ICGC	FRGCLQGVR	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.1667
p.R1756L	DO228971	LICA	ICGC	FRGCLQGVR	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.2778
p.D1769Y	DO229036	LICA	ICGC	FRGCLQGVR	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.25
p.G1067R	DO50970	LICA	ICGC	NASTGE	DEG_Kelch_Keap1_1	1076:1081	Mutation rewiring degron network	0.0833
p.S735N	DO23526	LIRI	ICGC	DEDTGE	DEG_Kelch_Keap1_1	738:743	Mutation rewiring degron network	0.25
p.M751I	DO220851	MELA	ICGC	DEDTGE	DEG_Kelch_Keap1_1	738:743	Mutation rewiring degron network	0.1111
p.D738N	DO222731	MELA	ICGC	DEDTGE	DEG_Kelch_Keap1_1	738:743	Mutation altering degron motif	0.5821
p.P378L	DO222837	MELA	ICGC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation altering degron motif	0.7582
p.T1770K	DO233292	NACA	ICGC	FRGCLQGVR	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.2222
p.A273G	SIDM01004	Chronic Myelogenous Leukemia	GDSC	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.6429
p.A273G	ACH-000983	Leukemia	CCLE	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.6429
p.A273G	KCL-22	haematopoietic and lymphoid tissue	COSMIC	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.6429
p.A1087T	SIDM00216	Colorectal Carcinoma	GDSC	NASTGE	DEG_Kelch_Keap1_1	1076:1081	Mutation rewiring degron network	0.1667
p.A1087T	ACH-000989	Colon/Colorectal Cancer	CCLE	NASTGE	DEG_Kelch_Keap1_1	1076:1081	Mutation rewiring degron network	0.1667
p.A1087T	SNU-175	large intestine	COSMIC	NASTGE	DEG_Kelch_Keap1_1	1076:1081	Mutation rewiring degron network	0.1667
p.P935A	SIDM00588	Oral Cavity Carcinoma	GDSC	FDVFVE	LIG_APCC_ABBA_1	926:931	Mutation rewiring degron network	0.2222
p.P935A	ACH-000546	Head and Neck Cancer	CCLE	FDVFVE	LIG_APCC_ABBA_1	926:931	Mutation rewiring degron network	0.2222
p.P935A	HSC-4	upper aerodigestive tract	COSMIC	FDVFVE	LIG_APCC_ABBA_1	926:931	Mutation rewiring degron network	0.2222
p.R374Q	SIDM00586	Hepatocellular Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2222
p.R374Q	ACH-000475	Liver Cancer	CCLE	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2222
p.R374Q	huH-1	liver	COSMIC	PRSTT	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2222
p.H285R	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.0833
p.H285R	ACH-002272	Lymphoma	CCLE	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.0833
p.H285R	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.0833
p.R1066Q	SIDM00200	Ewing's Sarcoma	GDSC	NASTGE	DEG_Kelch_Keap1_1	1076:1081	Mutation rewiring degron network	0.0556
p.R1066Q	SIDM00694	Other Solid Cancers	GDSC	NASTGE	DEG_Kelch_Keap1_1	1076:1081	Mutation rewiring degron network	0.0556
p.G265D	SIDM00783	Colorectal Carcinoma	GDSC	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.25
p.G265D	ACH-000971	Colon/Colorectal Cancer	CCLE	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.25
p.G265D	HCT-116	large intestine	COSMIC	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.25
p.G1080D	SIDM01617	Endometrial Carcinoma	GDSC	NASTGE	DEG_Kelch_Keap1_1	1076:1081	Mutation altering degron motif	0.7198
p.G1080D	ACH-000994	Endometrial/Uterine Cancer	CCLE	NASTGE	DEG_Kelch_Keap1_1	1076:1081	Mutation altering degron motif	0.7198
p.R1756G	SIDM01387	Small Cell Lung Carcinoma	GDSC	FRGCLQGVR	DEG_APCC_DBOX_1	1758:1766	Mutation rewiring degron network	0.2778
p.A736T	SIDM01451	Pancreatic Carcinoma	GDSC	DEDTGE	DEG_Kelch_Keap1_1	738:743	Mutation rewiring degron network	0.2778
p.A736T	ACH-000933	Pancreatic Cancer	CCLE	DEDTGE	DEG_Kelch_Keap1_1	738:743	Mutation rewiring degron network	0.2778
p.Q1763R	SIDM01619	Endometrial Carcinoma	GDSC	FRGCLQGVR	DEG_APCC_DBOX_1	1758:1766	Mutation altering degron motif	0.6218
p.I936S	ACH-000961	Endometrial/Uterine Cancer	CCLE	FDVFVE	LIG_APCC_ABBA_1	926:931	Mutation rewiring degron network	0.1944
p.R258G	ACH-001518	Endometrial/Uterine Cancer	CCLE	RRSALATLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CELSR2

UniProt ID: Q9HCU4

Entrez ID: 1952

Protein name: Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CELSR2 in