DegronMD

Uniprot ID: Q9HCU4

Source protein: Cadherin EGF LAG seven-pass G-type receptor 2

Source gene: CELSR2

Class: DEG_APCC_DBOX_1

Location: 268:276

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7068

ASA_SCORE: 49.5667

COIL: 0.1611

CONS_SCORE: 0.5643

DSS_SCORE: 0.4145

HELIX: 0.0037

FCONS_SCORE: 0.8762

RIG_SCORE: 0.7743

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P267S	TCGA-34-5927	LUSC	TCGA	RRSALATLT	DEG_APCC_DBOX_1	0.3056
p.P267S	DO27731	LUSC	ICGC	RRSALATLT	DEG_APCC_DBOX_1	0.3056
p.T276A	TCGA-43-2581	LUSC	TCGA	RRSALATLT	DEG_APCC_DBOX_1	0.6028
p.T276A	DO26602	LUSC	ICGC	RRSALATLT	DEG_APCC_DBOX_1	0.6028
p.A261T	TCGA-A5-A0G2	UCEC	TCGA	RRSALATLT	DEG_APCC_DBOX_1	0.1389
p.A261T	DO41235	UCEC	ICGC	RRSALATLT	DEG_APCC_DBOX_1	0.1389
p.R269L	TCGA-DQ-5630	HNSC	TCGA	RRSALATLT	DEG_APCC_DBOX_1	0.8428
p.R269L	TCGA-EY-A1G8	UCEC	TCGA	RRSALATLT	DEG_APCC_DBOX_1	0.8428
p.R269L	DO14486	HNSC	ICGC	RRSALATLT	DEG_APCC_DBOX_1	0.8428
p.R269L	DO43578	UCEC	ICGC	RRSALATLT	DEG_APCC_DBOX_1	0.8428
p.A261V	TCGA-DU-6392	LGG	TCGA	RRSALATLT	DEG_APCC_DBOX_1	0.1389
p.A261V	DO22237	LGG	ICGC	RRSALATLT	DEG_APCC_DBOX_1	0.1389
p.R269Q	TCGA-EO-A3AV	UCEC	TCGA	RRSALATLT	DEG_APCC_DBOX_1	0.7329
p.R269Q	DO52412	UCEC	ICGC	RRSALATLT	DEG_APCC_DBOX_1	0.7329
p.T282I	TCGA-FR-A8YC	SKCM	TCGA	RRSALATLT	DEG_APCC_DBOX_1	0.1667
p.T282I	DO50301	SKCM	ICGC	RRSALATLT	DEG_APCC_DBOX_1	0.1667
p.T260M	DO222884	COCA	ICGC	RRSALATLT	DEG_APCC_DBOX_1	0.1111
p.G265S	DO233791	GACA	ICGC	RRSALATLT	DEG_APCC_DBOX_1	0.25
p.A273G	SIDM01004	Chronic Myelogenous Leukemia	GDSC	RRSALATLT	DEG_APCC_DBOX_1	0.6429
p.A273G	ACH-000983	Leukemia	CCLE	RRSALATLT	DEG_APCC_DBOX_1	0.6429
p.A273G	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	RRSALATLT	DEG_APCC_DBOX_1	0.6429
p.H285R	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRSALATLT	DEG_APCC_DBOX_1	0.0833
p.H285R	ACH-002272	Lymphoma	CCLE	RRSALATLT	DEG_APCC_DBOX_1	0.0833
p.H285R	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	RRSALATLT	DEG_APCC_DBOX_1	0.0833
p.G265D	SIDM00783	Colorectal Carcinoma	GDSC	RRSALATLT	DEG_APCC_DBOX_1	0.25
p.G265D	ACH-000971	Colon/Colorectal Cancer	CCLE	RRSALATLT	DEG_APCC_DBOX_1	0.25
p.G265D	HCT-116	large_intestine	COSMIC	RRSALATLT	DEG_APCC_DBOX_1	0.25
p.R258G	ACH-001518	Endometrial/Uterine Cancer	CCLE	RRSALATLT	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRSALATLT

Degron related mutations and impact score

Drug responses associated with CELSR2 mutations

All proteins holding degron of RRSALATLT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCU4	Cadherin EGF LAG seven-pass G-type receptor 2	DEG_APCC_DBOX_1	268:276	RRSALATLT	APC,CDC20,FZR1	0.7068	More...