DegronMD

Uniprot ID: Q9HCU4

Source protein: Cadherin EGF LAG seven-pass G-type receptor 2

Source gene: CELSR2

Class: DEG_APCC_DBOX_1

Location: 1758:1766

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5681

ASA_SCORE: 33.0333

COIL: 0.5002

CONS_SCORE: 0.7148

DSS_SCORE: 0.405

HELIX: 0.0594

FCONS_SCORE: 2.0488

RIG_SCORE: 0.7691

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1752C	TCGA-55-A4DF	LUAD	TCGA	FRGCLQGVR	DEG_APCC_DBOX_1	0.1667
p.G1752C	DO45318	LUAD	ICGC	FRGCLQGVR	DEG_APCC_DBOX_1	0.1667
p.G1752S	TCGA-C4-A0F1	BLCA	TCGA	FRGCLQGVR	DEG_APCC_DBOX_1	0.1667
p.G1752S	TCGA-VQ-A91D	STAD	TCGA	FRGCLQGVR	DEG_APCC_DBOX_1	0.1667
p.G1752S	DO581	BLCA	ICGC	FRGCLQGVR	DEG_APCC_DBOX_1	0.1667
p.G1752S	DO51783	STAD	ICGC	FRGCLQGVR	DEG_APCC_DBOX_1	0.1667
p.A1755D	TCGA-EE-A29D	SKCM	TCGA	FRGCLQGVR	DEG_APCC_DBOX_1	0.25
p.A1755D	DO38123	SKCM	ICGC	FRGCLQGVR	DEG_APCC_DBOX_1	0.25
p.R1766Q	DO234329	ESAD	ICGC	FRGCLQGVR	DEG_APCC_DBOX_1	0.6218
p.R1766Q	ACH-002664	Colon/Colorectal Cancer	CCLE	FRGCLQGVR	DEG_APCC_DBOX_1	0.6218
p.E1772V	DO231984	LICA	ICGC	FRGCLQGVR	DEG_APCC_DBOX_1	0.1667
p.R1756L	DO228971	LICA	ICGC	FRGCLQGVR	DEG_APCC_DBOX_1	0.2778
p.D1769Y	DO229036	LICA	ICGC	FRGCLQGVR	DEG_APCC_DBOX_1	0.25
p.T1770K	DO233292	NACA	ICGC	FRGCLQGVR	DEG_APCC_DBOX_1	0.2222
p.R1756G	SIDM01387	Small Cell Lung Carcinoma	GDSC	FRGCLQGVR	DEG_APCC_DBOX_1	0.2778
p.Q1763R	SIDM01619	Endometrial Carcinoma	GDSC	FRGCLQGVR	DEG_APCC_DBOX_1	0.6218

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCU4	Cadherin EGF LAG seven-pass G-type receptor 2	DEG_APCC_DBOX_1	1758:1766	FRGCLQGVR	APC,CDC20,FZR1	0.5681	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons