DegronMD

Uniprot ID: Q9HCU4

Source protein: Cadherin EGF LAG seven-pass G-type receptor 2

Source gene: CELSR2

Class: DEG_Kelch_Keap1_1

Location: 1076:1081

E3 ligase: KEAP1

DEGRON score: 0.5678

ASA_SCORE: 48.2833

COIL: 0.7438

CONS_SCORE: 0.6202

DSS_SCORE: 0.1415

HELIX: 0.0143

FCONS_SCORE: 1.1809

RIG_SCORE: 0.7798

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1078F	TCGA-CE-A483	THCA	TCGA	NASTGE	DEG_Kelch_Keap1_1	0.7982
p.S1078F	DO38929	THCA	ICGC	NASTGE	DEG_Kelch_Keap1_1	0.7982
p.L1088P	TCGA-DI-A1BU	UCEC	TCGA	NASTGE	DEG_Kelch_Keap1_1	0.1389
p.L1088P	DO42023	UCEC	ICGC	NASTGE	DEG_Kelch_Keap1_1	0.1389
p.T1079M	DO227996	COCA	ICGC	NASTGE	DEG_Kelch_Keap1_1	0.7423
p.R1066L	DO233884	GACA	ICGC	NASTGE	DEG_Kelch_Keap1_1	0.0556
p.R1066L	DO229018	LICA	ICGC	NASTGE	DEG_Kelch_Keap1_1	0.0556
p.G1067R	DO50970	LICA	ICGC	NASTGE	DEG_Kelch_Keap1_1	0.0833
p.A1087T	SIDM00216	Colorectal Carcinoma	GDSC	NASTGE	DEG_Kelch_Keap1_1	0.1667
p.A1087T	ACH-000989	Colon/Colorectal Cancer	CCLE	NASTGE	DEG_Kelch_Keap1_1	0.1667
p.A1087T	SNU-175	large_intestine	COSMIC	NASTGE	DEG_Kelch_Keap1_1	0.1667
p.R1066Q	SIDM00200	Ewing's Sarcoma	GDSC	NASTGE	DEG_Kelch_Keap1_1	0.0556
p.R1066Q	SIDM00694	Other Solid Cancers	GDSC	NASTGE	DEG_Kelch_Keap1_1	0.0556
p.G1080D	SIDM01617	Endometrial Carcinoma	GDSC	NASTGE	DEG_Kelch_Keap1_1	0.7198
p.G1080D	ACH-000994	Endometrial/Uterine Cancer	CCLE	NASTGE	DEG_Kelch_Keap1_1	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCU4	Cadherin EGF LAG seven-pass G-type receptor 2	DEG_Kelch_Keap1_1	1076:1081	NASTGE	KEAP1	0.5678	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons