DegronMD

Uniprot ID: Q9HCU4

Source protein: Cadherin EGF LAG seven-pass G-type receptor 2

Source gene: CELSR2

Class: LIG_APCC_ABBA_1

Location: 926:931

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5095

ASA_SCORE: 43.6

COIL: 0.0202

CONS_SCORE: 0.5548

DSS_SCORE: 0.4075

HELIX: 0.002

FCONS_SCORE: 0.8385

RIG_SCORE: 0.8891

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S934N	TCGA-BR-8078	STAD	TCGA	FDVFVE	LIG_APCC_ABBA_1	0.25
p.S934N	DO38288	STAD	ICGC	FDVFVE	LIG_APCC_ABBA_1	0.25
p.N917T	TCGA-E6-A1LX	UCEC	TCGA	FDVFVE	LIG_APCC_ABBA_1	0.0833
p.N917T	DO41020	UCEC	ICGC	FDVFVE	LIG_APCC_ABBA_1	0.0833
p.P918S	TCGA-EE-A2MR	SKCM	TCGA	FDVFVE	LIG_APCC_ABBA_1	0.1111
p.P918S	DO37819	SKCM	ICGC	FDVFVE	LIG_APCC_ABBA_1	0.1111
p.F929L	DO228732	GACA	ICGC	FDVFVE	LIG_APCC_ABBA_1	0.6981
p.V940M	DO233731	GACA	ICGC	FDVFVE	LIG_APCC_ABBA_1	0.0833
p.P935A	SIDM00588	Oral Cavity Carcinoma	GDSC	FDVFVE	LIG_APCC_ABBA_1	0.2222
p.P935A	ACH-000546	Head and Neck Cancer	CCLE	FDVFVE	LIG_APCC_ABBA_1	0.2222
p.P935A	HSC-4	upper_aerodigestive_tract	COSMIC	FDVFVE	LIG_APCC_ABBA_1	0.2222
p.I936S	ACH-000961	Endometrial/Uterine Cancer	CCLE	FDVFVE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCU4	Cadherin EGF LAG seven-pass G-type receptor 2	LIG_APCC_ABBA_1	926:931	FDVFVE	APC,CDC20,FZR1	0.5095	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons