DegronMD

Uniprot ID: Q9HCU4

Source protein: Cadherin EGF LAG seven-pass G-type receptor 2

Source gene: CELSR2

Class: DEG_Kelch_Keap1_1

Location: 738:743

E3 ligase: KEAP1

DEGRON score: 0.9359

ASA_SCORE: 65.95

COIL: 0.703

CONS_SCORE: 0.6487

DSS_SCORE: 0.3533

HELIX: 0.0293

FCONS_SCORE: 1.0445

RIG_SCORE: 0.7725

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E752K	TCGA-55-8089	LUAD	TCGA	DEDTGE	DEG_Kelch_Keap1_1	0.0833
p.E752K	DO23690	LUAD	ICGC	DEDTGE	DEG_Kelch_Keap1_1	0.0833
p.R746H	TCGA-AD-6889	COAD	TCGA	DEDTGE	DEG_Kelch_Keap1_1	0.25
p.R746H	DO8858	COAD	ICGC	DEDTGE	DEG_Kelch_Keap1_1	0.25
p.R746H	DO8463	COAD	ICGC	DEDTGE	DEG_Kelch_Keap1_1	0.25
p.G728D	TCGA-BG-A222	UCEC	TCGA	DEDTGE	DEG_Kelch_Keap1_1	0.0556
p.G728D	DO42977	UCEC	ICGC	DEDTGE	DEG_Kelch_Keap1_1	0.0556
p.E743D	TCGA-D1-A1NZ	UCEC	TCGA	DEDTGE	DEG_Kelch_Keap1_1	0.6758
p.E743D	DO41536	UCEC	ICGC	DEDTGE	DEG_Kelch_Keap1_1	0.6758
p.S735G	TCGA-D8-A1XQ	BRCA	TCGA	DEDTGE	DEG_Kelch_Keap1_1	0.25
p.S735G	DO3095	BRCA	ICGC	DEDTGE	DEG_Kelch_Keap1_1	0.25
p.T737M	TCGA-EY-A1GQ	UCEC	TCGA	DEDTGE	DEG_Kelch_Keap1_1	0.3056
p.T737M	DO43090	UCEC	ICGC	DEDTGE	DEG_Kelch_Keap1_1	0.3056
p.R746C	TCGA-QB-A6FS	SKCM	TCGA	DEDTGE	DEG_Kelch_Keap1_1	0.25
p.R746C	DO48654	SKCM	ICGC	DEDTGE	DEG_Kelch_Keap1_1	0.25
p.M751T	DO234239	ESAD	ICGC	DEDTGE	DEG_Kelch_Keap1_1	0.1111
p.S735N	DO23526	LIRI	ICGC	DEDTGE	DEG_Kelch_Keap1_1	0.25
p.M751I	DO220851	MELA	ICGC	DEDTGE	DEG_Kelch_Keap1_1	0.1111
p.D738N	DO222731	MELA	ICGC	DEDTGE	DEG_Kelch_Keap1_1	0.5821
p.A736T	SIDM01451	Pancreatic Carcinoma	GDSC	DEDTGE	DEG_Kelch_Keap1_1	0.2778
p.A736T	ACH-000933	Pancreatic Cancer	CCLE	DEDTGE	DEG_Kelch_Keap1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCU4	Cadherin EGF LAG seven-pass G-type receptor 2	DEG_Kelch_Keap1_1	738:743	DEDTGE	KEAP1	0.9359	More...
Q9NYQ6	Cadherin EGF LAG seven-pass G-type receptor 1	DEG_Kelch_Keap1_1	815:820	DEDTGE	KEAP1	0.785	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons