DegronMD

Uniprot ID: Q9HCU4

Source protein: Cadherin EGF LAG seven-pass G-type receptor 2

Source gene: CELSR2

Class: DEG_SPOP_SBC_1

Location: 378:382

E3 ligase: SPOP

DEGRON score: 0.8201

ASA_SCORE: 55.68

COIL: 0.4358

CONS_SCORE: 0.5609

DSS_SCORE: 0.5988

HELIX: 0.0068

FCONS_SCORE: 1.0042

RIG_SCORE: 0.6403

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R379W	TCGA-D1-A0ZQ	UCEC	TCGA	PRSTT	DEG_SPOP_SBC_1	0.7523
p.R379W	DO41879	UCEC	ICGC	PRSTT	DEG_SPOP_SBC_1	0.7523
p.S388P	TCGA-DS-A1OA	CESC	TCGA	PRSTT	DEG_SPOP_SBC_1	0.1667
p.S388P	DO6341	CESC	ICGC	PRSTT	DEG_SPOP_SBC_1	0.1667
p.E390K	TCGA-EO-A22U	UCEC	TCGA	PRSTT	DEG_SPOP_SBC_1	0.1111
p.E390K	DO43755	UCEC	ICGC	PRSTT	DEG_SPOP_SBC_1	0.1111
p.E390D	TCGA-F5-6814	READ	TCGA	PRSTT	DEG_SPOP_SBC_1	0.1111
p.E390D	TCGA-XK-AAIW	PRAD	TCGA	PRSTT	DEG_SPOP_SBC_1	0.1111
p.E390D	DO51407	PRAD	ICGC	PRSTT	DEG_SPOP_SBC_1	0.1111
p.E390D	DO36556	READ	ICGC	PRSTT	DEG_SPOP_SBC_1	0.1111
p.S388F	TCGA-XF-AAMR	BLCA	TCGA	PRSTT	DEG_SPOP_SBC_1	0.1667
p.S388F	DO51935	BLCA	ICGC	PRSTT	DEG_SPOP_SBC_1	0.1667
p.A384S	DO229489	LAML	ICGC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM00630	Breast Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM01040	Ovarian Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM00362	Burkitt's Lymphoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM01005	Acute Myeloid Leukemia	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM00193	Colorectal Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM00057	Neuroblastoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM00589	Oral Cavity Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM00552	Rhabdomyosarcoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM01196	Hepatocellular Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM00301	Pancreatic Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM00282	Colorectal Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM00562	Breast Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM01172	Acute Myeloid Leukemia	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM00587	Biliary Tract Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM00251	Gastric Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM00397	Acute Myeloid Leukemia	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM01660	Kidney Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM01377	Ovarian Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM01763	Rhabdomyosarcoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.A384S	SIDM00162	Biliary Tract Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.P378L	DO222837	MELA	ICGC	PRSTT	DEG_SPOP_SBC_1	0.7582
p.R374Q	SIDM00586	Hepatocellular Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.2222
p.R374Q	ACH-000475	Liver Cancer	CCLE	PRSTT	DEG_SPOP_SBC_1	0.2222
p.R374Q	huH-1	liver	COSMIC	PRSTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01880	Immunoglobulin heavy constant delta	DEG_SPOP_SBC_1	329:333	PRSTT	SPOP	0.8106	More...
P78559	Microtubule-associated protein 1A	DEG_SPOP_SBC_1	2647:2651	PRSTT	SPOP	0.9396	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	588:592	PRSTT	SPOP	0.993	More...
Q6IQ55	Tau-tubulin kinase 2	DEG_SPOP_SBC_1	1122:1126	PRSTT	SPOP	0.5437	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	252:256	PRSTT	SPOP	0.991	More...
Q9HCU4	Cadherin EGF LAG seven-pass G-type receptor 2	DEG_SPOP_SBC_1	378:382	PRSTT	SPOP	0.8201	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRSTT

Degron related mutations and impact score

Drug responses associated with CELSR2 mutations

All proteins holding degron of PRSTT