DegronMD - P78559(MAP1A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F1876L	TCGA-22-5473	LUSC	TCGA	PPTPAPE	DEG_SCF_FBW7_2	1863:1869	Mutation rewiring degron network	0.1389
p.F1876L	DO26467	LUSC	ICGC	PPTPAPE	DEG_SCF_FBW7_2	1863:1869	Mutation rewiring degron network	0.1389
p.R1143Q	TCGA-90-A4ED	LUSC	TCGA	ESLSVLSVPSP	DEG_COP1_1	1151:1161	Mutation rewiring degron network	0.1111
p.R1143Q	TCGA-EE-A2MR	SKCM	TCGA	ESLSVLSVPSP	DEG_COP1_1	1151:1161	Mutation rewiring degron network	0.1111
p.R1143Q	DO45482	LUSC	ICGC	ESLSVLSVPSP	DEG_COP1_1	1151:1161	Mutation rewiring degron network	0.1111
p.R1143Q	DO37819	SKCM	ICGC	ESLSVLSVPSP	DEG_COP1_1	1151:1161	Mutation rewiring degron network	0.1111
p.P1327L	TCGA-AA-3663	COAD	TCGA	ILTPDSS	DEG_SCF_FBW7_1	1316:1322	Mutation rewiring degron network	0.1944
p.P1327L	DO9346	COAD	ICGC	ILTPDSS	DEG_SCF_FBW7_1	1316:1322	Mutation rewiring degron network	0.1944
p.A1942V	TCGA-AA-A010	COAD	TCGA	SSHSSKVPEA	DEG_COP1_1	1928:1937	Mutation rewiring degron network	0.1944
p.R2648H	TCGA-AJ-A8CW	UCEC	TCGA	PRSTT	DEG_SPOP_SBC_1	2647:2651	Mutation altering degron motif	0.7133
p.R2648H	DO233707	GACA	ICGC	PRSTT	DEG_SPOP_SBC_1	2647:2651	Mutation altering degron motif	0.7133
p.R2648H	DO52400	UCEC	ICGC	PRSTT	DEG_SPOP_SBC_1	2647:2651	Mutation altering degron motif	0.7133
p.S605N	TCGA-AP-A1DK	UCEC	TCGA	DSGAET	DEG_SCF_TRCP1_1	611:616	Mutation blocking phosphorylation signal	0.6111
p.S605N	DO42033	UCEC	ICGC	DSGAET	DEG_SCF_TRCP1_1	611:616	Mutation blocking phosphorylation signal	0.6111
p.K1171N	TCGA-AP-A1DV	UCEC	TCGA	ESLSVLSVPSP	DEG_COP1_1	1151:1161	Mutation substituting flanking lysine	0.1667
p.K1171N	DO43186	UCEC	ICGC	ESLSVLSVPSP	DEG_COP1_1	1151:1161	Mutation substituting flanking lysine	0.1667
p.D621Y	TCGA-AX-A05Z	UCEC	TCGA	DSGAET	DEG_SCF_TRCP1_1	611:616	Mutation rewiring degron network	0.1944
p.D621Y	DO40884	UCEC	ICGC	DSGAET	DEG_SCF_TRCP1_1	611:616	Mutation rewiring degron network	0.1944
p.D791N	TCGA-AX-A06F	UCEC	TCGA	VYGTPETE	DEG_SCF_FBW7_2	801:808	Mutation rewiring degron network	0.0556
p.D791N	DO41752	UCEC	ICGC	VYGTPETE	DEG_SCF_FBW7_2	801:808	Mutation rewiring degron network	0.0556
p.T1163I	TCGA-AX-A06F	UCEC	TCGA	ESLSVLSVPSP	DEG_COP1_1	1151:1161	Mutation blocking phosphorylation signal	0.7222
p.T1163I	DO41752	UCEC	ICGC	ESLSVLSVPSP	DEG_COP1_1	1151:1161	Mutation blocking phosphorylation signal	0.7222
p.A2503S	TCGA-AX-A1CK	UCEC	TCGA	DSGSSQS	DEG_SCF_TRCP1_1	2505:2511	Mutation rewiring degron network	0.2778
p.A2503S	DO41815	UCEC	ICGC	DSGSSQS	DEG_SCF_TRCP1_1	2505:2511	Mutation rewiring degron network	0.2778
p.S1324Y	TCGA-BF-A1PX	SKCM	TCGA	ILTPDSS	DEG_SCF_FBW7_1	1316:1322	Mutation rewiring degron network	0.2778
p.S1324Y	DO51236	SKCM	ICGC	ILTPDSS	DEG_SCF_FBW7_1	1316:1322	Mutation rewiring degron network	0.2778
p.R2648C	TCGA-BG-A221	UCEC	TCGA	PRSTT	DEG_SPOP_SBC_1	2647:2651	Mutation altering degron motif	0.719
p.R2648C	DO42384	UCEC	ICGC	PRSTT	DEG_SPOP_SBC_1	2647:2651	Mutation altering degron motif	0.719
p.L1317P	TCGA-BR-6452	STAD	TCGA	ILTPDSS	DEG_SCF_FBW7_1	1316:1322	Mutation altering degron motif	0.6471
p.L1317P	DO38404	STAD	ICGC	ILTPDSS	DEG_SCF_FBW7_1	1316:1322	Mutation altering degron motif	0.6471
p.L1317V	TCGA-BR-7901	STAD	TCGA	ILTPDSS	DEG_SCF_FBW7_1	1316:1322	Mutation altering degron motif	0.5654
p.L1317V	DO38463	STAD	ICGC	ILTPDSS	DEG_SCF_FBW7_1	1316:1322	Mutation altering degron motif	0.5654
p.K1907N	TCGA-CA-5255	COAD	TCGA	DYR	CBL_MET	1908:1910	Mutation rewiring degron network	0.3056
p.K1907N	DO10052	COAD	ICGC	DYR	CBL_MET	1908:1910	Mutation rewiring degron network	0.3056
p.E1314K	TCGA-DC-6683	READ	TCGA	ILTPDSS	DEG_SCF_FBW7_1	1316:1322	Mutation rewiring degron network	0.2778
p.E1314K	DO37018	READ	ICGC	ILTPDSS	DEG_SCF_FBW7_1	1316:1322	Mutation rewiring degron network	0.2778
p.R1910C	TCGA-DD-AACZ	LIHC	TCGA	DYR	CBL_MET	1908:1910	Mutation altering degron motif	0.8301
p.R1910C	DO52216	LIHC	ICGC	DYR	CBL_MET	1908:1910	Mutation altering degron motif	0.8301
p.P1854A	TCGA-DJ-A3VA	THCA	TCGA	PPTPAPE	DEG_SCF_FBW7_2	1863:1869	Mutation rewiring degron network	0.0833
p.P1854A	DO40286	THCA	ICGC	PPTPAPE	DEG_SCF_FBW7_2	1863:1869	Mutation rewiring degron network	0.0833
p.P1866H	TCGA-DU-6392	LGG	TCGA	PPTPAPE	DEG_SCF_FBW7_2	1863:1869	Mutation altering degron motif	0.7694
p.P1866H	DO22237	LGG	ICGC	PPTPAPE	DEG_SCF_FBW7_2	1863:1869	Mutation altering degron motif	0.7694
p.E2497K	TCGA-EE-A29D	SKCM	TCGA	DSGSSQS	DEG_SCF_TRCP1_1	2505:2511	Mutation rewiring degron network	0.1111
p.E2497K	DO38123	SKCM	ICGC	DSGSSQS	DEG_SCF_TRCP1_1	2505:2511	Mutation rewiring degron network	0.1111
p.E2497K	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	DSGSSQS	DEG_SCF_TRCP1_1	2505:2511	Mutation rewiring degron network	0.1111
p.E2497K	NCI-H2347	lung	COSMIC	DSGSSQS	DEG_SCF_TRCP1_1	2505:2511	Mutation rewiring degron network	0.1111
p.T622I	TCGA-FR-A729	SKCM	TCGA	DSGAET	DEG_SCF_TRCP1_1	611:616	Mutation blocking phosphorylation signal	0.6111
p.T622I	DO48618	SKCM	ICGC	DSGAET	DEG_SCF_TRCP1_1	611:616	Mutation blocking phosphorylation signal	0.6111
p.E1913K	TCGA-FW-A3R5	SKCM	TCGA	DYR	CBL_MET	1908:1910	Mutation rewiring degron network	0.25
p.E1913K	DO37406	SKCM	ICGC	DYR	CBL_MET	1908:1910	Mutation rewiring degron network	0.25
p.S1940N	TCGA-FW-A3R5	SKCM	TCGA	SSHSSKVPEA	DEG_COP1_1	1928:1937	Mutation rewiring degron network	0.25
p.S1940N	DO37406	SKCM	ICGC	SSHSSKVPEA	DEG_COP1_1	1928:1937	Mutation rewiring degron network	0.25
p.P1859Q	TCGA-GN-A262	SKCM	TCGA	PPTPAPE	DEG_SCF_FBW7_2	1863:1869	Mutation rewiring degron network	0.2222
p.P1859Q	DO37515	SKCM	ICGC	PPTPAPE	DEG_SCF_FBW7_2	1863:1869	Mutation rewiring degron network	0.2222
p.R1921K	TCGA-T3-A92M	HNSC	TCGA	SSHSSKVPEA	DEG_COP1_1	1928:1937	Mutation rewiring degron network	0.1389
p.R1921K	DO223269	HNSC	ICGC	SSHSSKVPEA	DEG_COP1_1	1928:1937	Mutation rewiring degron network	0.1389
p.T1944K	TCGA-VR-A8EX	ESCA	TCGA	SSHSSKVPEA	DEG_COP1_1	1928:1937	Mutation rewiring degron network	0.1389
p.P1327S	TCGA-YG-AA3N	SKCM	TCGA	ILTPDSS	DEG_SCF_FBW7_1	1316:1322	Mutation rewiring degron network	0.1944
p.P1327S	DO51298	SKCM	ICGC	ILTPDSS	DEG_SCF_FBW7_1	1316:1322	Mutation rewiring degron network	0.1944
p.L1330V	TCGA-Z2-AA3V	SKCM	TCGA	ILTPDSS	DEG_SCF_FBW7_1	1316:1322	Mutation rewiring degron network	0.1111
p.L1330V	DO51303	SKCM	ICGC	ILTPDSS	DEG_SCF_FBW7_1	1316:1322	Mutation rewiring degron network	0.1111
p.K1927E	DO230334	COCA	ICGC	SSHSSKVPEA	DEG_COP1_1	1928:1937	Mutation rewiring degron network	0.3056
p.T1310I	DO234189	ESAD	ICGC	ILTPDSS	DEG_SCF_FBW7_1	1316:1322	Mutation rewiring degron network	0.1667
p.P1331S	DO233267	GACA	ICGC	ILTPDSS	DEG_SCF_FBW7_1	1316:1322	Mutation rewiring degron network	0.0833
p.G1332V	DO233898	GACA	ICGC	ILTPDSS	DEG_SCF_FBW7_1	1316:1322	Mutation rewiring degron network	0.0556
p.R2639L	DO228974	LICA	ICGC	PRSTT	DEG_SPOP_SBC_1	2647:2651	Mutation rewiring degron network	0.1111
p.E1945D	DO229028	LICA	ICGC	SSHSSKVPEA	DEG_COP1_1	1928:1937	Mutation rewiring degron network	0.1111
p.V1155F	DO229037	LICA	ICGC	ESLSVLSVPSP	DEG_COP1_1	1151:1161	Mutation altering degron motif	0.5957
p.V1158L	DO229008	LICA	ICGC	ESLSVLSVPSP	DEG_COP1_1	1151:1161	Mutation altering degron motif	0.6765
p.P1170L	DO50970	LICA	ICGC	ESLSVLSVPSP	DEG_COP1_1	1151:1161	Mutation rewiring degron network	0.0833
p.P2500L	DO50967	LICA	ICGC	DSGSSQS	DEG_SCF_TRCP1_1	2505:2511	Mutation rewiring degron network	0.1944
p.P2500L	DO229462	SKCA	ICGC	DSGSSQS	DEG_SCF_TRCP1_1	2505:2511	Mutation rewiring degron network	0.1944
p.P1925H	DO228253	MALY	ICGC	SSHSSKVPEA	DEG_COP1_1	1928:1937	Mutation rewiring degron network	0.25
p.G1906R	DO51493	PACA	ICGC	DYR	CBL_MET	1908:1910	Mutation rewiring degron network	0.2778
p.P1864S	DO230500	PRAD	ICGC	PPTPAPE	DEG_SCF_FBW7_2	1863:1869	Mutation altering degron motif	0.5641
p.G799D	DO229216	THCA	ICGC	VYGTPETE	DEG_SCF_FBW7_2	801:808	Mutation rewiring degron network	0.2778
p.T2655N	SIDM00377	Other Sarcomas	GDSC	PRSTT	DEG_SPOP_SBC_1	2647:2651	Mutation blocking phosphorylation signal	0.6667
p.T2655N	SKN	soft tissue	COSMIC	PRSTT	DEG_SPOP_SBC_1	2647:2651	Mutation blocking phosphorylation signal	0.6667
p.P812A	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	VYGTPETE	DEG_SCF_FBW7_2	801:808	Mutation rewiring degron network	0.2222
p.P812A	NCI-H1299	lung	COSMIC	VYGTPETE	DEG_SCF_FBW7_2	801:808	Mutation rewiring degron network	0.2222
p.R2642Q	SIDM01199	Hepatocellular Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	2647:2651	Mutation rewiring degron network	0.1944
p.R2642Q	SNU-423	liver	COSMIC	PRSTT	DEG_SPOP_SBC_1	2647:2651	Mutation rewiring degron network	0.1944
p.R1910H	SIDM00120	Prostate Carcinoma	GDSC	DYR	CBL_MET	1908:1910	Mutation altering degron motif	0.8244
p.R1910H	DU-145	prostate	COSMIC	DYR	CBL_MET	1908:1910	Mutation altering degron motif	0.8244
p.S2641F	SIDM00007	Other Solid Cancers	GDSC	PRSTT	DEG_SPOP_SBC_1	2647:2651	Mutation rewiring degron network	0.1667
p.S2641F	MCC13	skin	COSMIC	PRSTT	DEG_SPOP_SBC_1	2647:2651	Mutation rewiring degron network	0.1667
p.A2637V	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	2647:2651	Mutation rewiring degron network	0.0556
p.A2637V	KYSE-140	oesophagus	COSMIC	PRSTT	DEG_SPOP_SBC_1	2647:2651	Mutation rewiring degron network	0.0556
p.R1916M	SIDM00683	Prostate Carcinoma	GDSC	DYR	CBL_MET	1908:1910	Mutation rewiring degron network	0.1667
p.R1916M	ACH-000977	lymph node	CCLE	DYR	CBL_MET	1908:1910	Mutation rewiring degron network	0.1667
p.R1916M	LNCaP-Clone-FGC	prostate	COSMIC	DYR	CBL_MET	1908:1910	Mutation rewiring degron network	0.1667
p.E601K	SIDM01190	Bladder Carcinoma	GDSC	DSGAET	DEG_SCF_TRCP1_1	611:616	Mutation rewiring degron network	0.0556
p.E601K	TCCSUP	urinary tract	COSMIC	DSGAET	DEG_SCF_TRCP1_1	611:616	Mutation rewiring degron network	0.0556
p.V1158M	SIDM01220	Glioma	GDSC	ESLSVLSVPSP	DEG_COP1_1	1151:1161	Mutation altering degron motif	0.7208
p.V1158M	LNZTA3WT4	central nervous system	COSMIC	ESLSVLSVPSP	DEG_COP1_1	1151:1161	Mutation altering degron motif	0.7208
p.P1147A	SIDM00675	Breast Carcinoma	GDSC	ESLSVLSVPSP	DEG_COP1_1	1151:1161	Mutation rewiring degron network	0.2222
p.P1147A	HCC38	breast	COSMIC	ESLSVLSVPSP	DEG_COP1_1	1151:1161	Mutation rewiring degron network	0.2222
p.P1312R	SIDM00882	Breast Carcinoma	GDSC	ILTPDSS	DEG_SCF_FBW7_1	1316:1322	Mutation rewiring degron network	0.2222
p.P1312R	HCC1419	breast	COSMIC	ILTPDSS	DEG_SCF_FBW7_1	1316:1322	Mutation rewiring degron network	0.2222
p.R2512H	ACH-000205	Pancreatic Cancer	CCLE	DSGSSQS	DEG_SCF_TRCP1_1	2505:2511	Mutation rewiring degron network	0.3056
p.I1165T	ACH-000390	Lung Cancer	CCLE	ESLSVLSVPSP	DEG_COP1_1	1151:1161	Mutation rewiring degron network	0.2222
p.A2501S	ACH-000476	Liver Cancer	CCLE	DSGSSQS	DEG_SCF_TRCP1_1	2505:2511	Mutation rewiring degron network	0.2222
p.A2501S	JHH-4	liver	COSMIC	DSGSSQS	DEG_SCF_TRCP1_1	2505:2511	Mutation rewiring degron network	0.2222
p.P798S	ACH-000624	Breast Cancer	CCLE	VYGTPETE	DEG_SCF_FBW7_2	801:808	Mutation rewiring degron network	0.25
p.P798S	ACH-000856	Breast Cancer	CCLE	VYGTPETE	DEG_SCF_FBW7_2	801:808	Mutation rewiring degron network	0.25
p.P798S	CAL-51	breast	COSMIC	VYGTPETE	DEG_SCF_FBW7_2	801:808	Mutation rewiring degron network	0.25
p.P798S	HCC1806	breast	COSMIC	VYGTPETE	DEG_SCF_FBW7_2	801:808	Mutation rewiring degron network	0.25
p.S1913T	ACH-000639	Lung Cancer	CCLE	DYR	CBL_MET	1908:1910	Mutation rewiring degron network	0.25
p.S1913T	NCI-H211	lung	COSMIC	DYR	CBL_MET	1908:1910	Mutation rewiring degron network	0.25
p.D794N	ACH-000677	Lung Cancer	CCLE	VYGTPETE	DEG_SCF_FBW7_2	801:808	Mutation rewiring degron network	0.1389
p.D794N	SW1573	lung	COSMIC	VYGTPETE	DEG_SCF_FBW7_2	801:808	Mutation rewiring degron network	0.1389
p.I1317S	ACH-000764	Gastric Cancer	CCLE	ILTPDSS	DEG_SCF_FBW7_1	1316:1322	Mutation altering degron motif	0.7341
p.G1900A	ACH-000852	Lung Cancer	CCLE	DYR	CBL_MET	1908:1910	Mutation rewiring degron network	0.1111
p.G1900A	NCI-H1435	lung	COSMIC	DYR	CBL_MET	1908:1910	Mutation rewiring degron network	0.1111
p.R1942W	ACH-000895	Colon/Colorectal Cancer	CCLE	SSHSSKVPEA	DEG_COP1_1	1928:1937	Mutation rewiring degron network	0.1944
p.R1942W	CL-34	large intestine	COSMIC	SSHSSKVPEA	DEG_COP1_1	1928:1937	Mutation rewiring degron network	0.1944
p.E1937K	ACH-000968	Skin Cancer	CCLE	SSHSSKVPEA	DEG_COP1_1	1928:1937	Mutation altering degron motif	0.7022
p.E1937K	COLO-792	skin	COSMIC	SSHSSKVPEA	DEG_COP1_1	1928:1937	Mutation altering degron motif	0.7022
p.A1871P	ACH-000978	Endometrial/Uterine Cancer	CCLE	PPTPAPE	DEG_SCF_FBW7_2	1863:1869	Mutation rewiring degron network	0.2778
p.A1871P	EN	endometrium	COSMIC	PPTPAPE	DEG_SCF_FBW7_2	1863:1869	Mutation rewiring degron network	0.2778
p.A1331T	ACH-000988	Endometrial/Uterine Cancer	CCLE	ILTPDSS	DEG_SCF_FBW7_1	1316:1322	Mutation rewiring degron network	0.0833
p.A1331T	MFE-319	endometrium	COSMIC	ILTPDSS	DEG_SCF_FBW7_1	1316:1322	Mutation rewiring degron network	0.0833
p.E1873A	ACH-000993	Endometrial/Uterine Cancer	CCLE	PPTPAPE	DEG_SCF_FBW7_2	1863:1869	Mutation rewiring degron network	0.2222
p.T1156I	ACH-000994	Endometrial/Uterine Cancer	CCLE	ESLSVLSVPSP	DEG_COP1_1	1151:1161	Mutation altering degron motif	0.7078
p.F1153L	ACH-000996	Endometrial/Uterine Cancer	CCLE	ESLSVLSVPSP	DEG_COP1_1	1151:1161	Mutation altering degron motif	0.6981
p.R1924I	ACH-002272	Lymphoma	CCLE	SSHSSKVPEA	DEG_COP1_1	1928:1937	Mutation rewiring degron network	0.2222
p.R1924I	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	SSHSSKVPEA	DEG_COP1_1	1928:1937	Mutation rewiring degron network	0.2222
p.P1161S	ACH-002396	Bone Cancer	CCLE	ESLSVLSVPSP	DEG_COP1_1	1151:1161	Mutation altering degron motif	0.6752
p.P1161S	Sarc9371	bone	COSMIC	ESLSVLSVPSP	DEG_COP1_1	1151:1161	Mutation altering degron motif	0.6752
p.G1869D	OCUB-M	breast	COSMIC	PPTPAPE	DEG_SCF_FBW7_2	1863:1869	Mutation altering degron motif	0.7198
p.G1869D	LNCaP-Clone-FGC	prostate	COSMIC	PPTPAPE	DEG_SCF_FBW7_2	1863:1869	Mutation altering degron motif	0.7198
p.S1160P	IM-95	stomach	COSMIC	ESLSVLSVPSP	DEG_COP1_1	1151:1161	Mutation altering degron motif	0.7863
p.G2659D	LC4-1	haematopoietic and lymphoid tissue	COSMIC	PRSTT	DEG_SPOP_SBC_1	2647:2651	Mutation rewiring degron network	0.1111
p.G2659D	JHH-4	liver	COSMIC	PRSTT	DEG_SPOP_SBC_1	2647:2651	Mutation rewiring degron network	0.1111
p.T2643A	ONS-76	central nervous system	COSMIC	PRSTT	DEG_SPOP_SBC_1	2647:2651	Mutation rewiring degron network	0.2222
p.T2643A	NCC021	kidney	COSMIC	PRSTT	DEG_SPOP_SBC_1	2647:2651	Mutation rewiring degron network	0.2222
p.P2661S	SW13	adrenal gland	COSMIC	PRSTT	DEG_SPOP_SBC_1	2647:2651	Mutation rewiring degron network	0.0556
p.D2642H	JHH-7	liver	COSMIC	PRSTT	DEG_SPOP_SBC_1	2647:2651	Mutation rewiring degron network	0.1944
p.D1152E	HuP-T4	pancreas	COSMIC	ESLSVLSVPSP	DEG_COP1_1	1151:1161	Mutation altering degron motif	0.6758

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP1A

UniProt ID: P78559

Entrez ID: 4130

Protein name: Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAP1A in