DegronMD

Uniprot ID: P78559

Source protein: Microtubule-associated protein 1A

Source gene: MAP1A

Class: DEG_SCF_TRCP1_1

Location: 2505:2511

E3 ligase: BTRC

DEGRON score: 0.9876

ASA_SCORE: 76.3429

COIL: 0.9164

CONS_SCORE: 0.6172

DSS_SCORE: 0.8735

HELIX: 0.0603

FCONS_SCORE: 1.0591

RIG_SCORE: 0.4968

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2503S	TCGA-AX-A1CK	UCEC	TCGA	DSGSSQS	DEG_SCF_TRCP1_1	0.2778
p.A2503S	DO41815	UCEC	ICGC	DSGSSQS	DEG_SCF_TRCP1_1	0.2778
p.E2497K	TCGA-EE-A29D	SKCM	TCGA	DSGSSQS	DEG_SCF_TRCP1_1	0.1111
p.E2497K	DO38123	SKCM	ICGC	DSGSSQS	DEG_SCF_TRCP1_1	0.1111
p.E2497K	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	DSGSSQS	DEG_SCF_TRCP1_1	0.1111
p.E2497K	NCI-H2347	lung	COSMIC	DSGSSQS	DEG_SCF_TRCP1_1	0.1111
p.P2500L	DO50967	LICA	ICGC	DSGSSQS	DEG_SCF_TRCP1_1	0.1944
p.P2500L	DO229462	SKCA	ICGC	DSGSSQS	DEG_SCF_TRCP1_1	0.1944
p.R2512H	ACH-000205	Pancreatic Cancer	CCLE	DSGSSQS	DEG_SCF_TRCP1_1	0.3056
p.A2501S	ACH-000476	Liver Cancer	CCLE	DSGSSQS	DEG_SCF_TRCP1_1	0.2222
p.A2501S	JHH-4	liver	COSMIC	DSGSSQS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78559	Microtubule-associated protein 1A	DEG_SCF_TRCP1_1	2505:2511	DSGSSQS	BTRC	0.9876	More...
A6NKL6	Transmembrane protein 200C	DEG_SCF_TRCP1_1	521:527	DSGSSQS	BTRC	0.9801	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons