DegronMD

Uniprot ID: A6NKL6

Source protein: Transmembrane protein 200C

Source gene: TMEM200C

Class: DEG_SCF_TRCP1_1

Location: 521:527

E3 ligase: BTRC

DEGRON score: 0.9801

ASA_SCORE: 87.2286

COIL: 0.9289

CONS_SCORE: 0.4143

DSS_SCORE: 0.8601

HELIX: 0.0507

FCONS_SCORE: 0.9655

RIG_SCORE: 0.4666

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P530T	TCGA-HF-A5NB	STAD	TCGA	DSGSSQS	DEG_SCF_TRCP1_1	0.25
p.P530T	DO50127	STAD	ICGC	DSGSSQS	DEG_SCF_TRCP1_1	0.25
p.S533R	DO222419	BTCA	ICGC	DSGSSQS	DEG_SCF_TRCP1_1	0.1667
p.D529E	DO229034	LICA	ICGC	DSGSSQS	DEG_SCF_TRCP1_1	0.2778
p.D521E	DO229035	LICA	ICGC	DSGSSQS	DEG_SCF_TRCP1_1	0.6758
p.S522F	DO220906	MELA	ICGC	DSGSSQS	DEG_SCF_TRCP1_1	0.7982
p.D528E	SIDM00594	Acute Myeloid Leukemia	GDSC	DSGSSQS	DEG_SCF_TRCP1_1	0.3056
p.D528E	ACH-000004	Leukemia	CCLE	DSGSSQS	DEG_SCF_TRCP1_1	0.3056
p.D528E	ACH-000005	Leukemia	CCLE	DSGSSQS	DEG_SCF_TRCP1_1	0.3056
p.D528E	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSSQS	DEG_SCF_TRCP1_1	0.3056
p.P530L	SIDM00260	Gastric Carcinoma	GDSC	DSGSSQS	DEG_SCF_TRCP1_1	0.25
p.P530L	SIDM00248	Gastric Carcinoma	GDSC	DSGSSQS	DEG_SCF_TRCP1_1	0.25
p.P530L	ACH-000758	Gastric Cancer	CCLE	DSGSSQS	DEG_SCF_TRCP1_1	0.25
p.P530L	MKN28	stomach	COSMIC	DSGSSQS	DEG_SCF_TRCP1_1	0.25
p.S515W	SIDM00346	Chronic Myelogenous Leukemia	GDSC	DSGSSQS	DEG_SCF_TRCP1_1	0.1667
p.S515W	ACH-000301	Leukemia	CCLE	DSGSSQS	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78559	Microtubule-associated protein 1A	DEG_SCF_TRCP1_1	2505:2511	DSGSSQS	BTRC	0.9876	More...
A6NKL6	Transmembrane protein 200C	DEG_SCF_TRCP1_1	521:527	DSGSSQS	BTRC	0.9801	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons