DegronMD

Uniprot ID: P78559

Source protein: Microtubule-associated protein 1A

Source gene: MAP1A

Class: DEG_SCF_FBW7_2

Location: 1863:1869

E3 ligase: FBXW7

DEGRON score: 0.977

ASA_SCORE: 97.9714

COIL: 0.959

CONS_SCORE: 0.5385

DSS_SCORE: 0.7148

HELIX: 0.0213

FCONS_SCORE: 1.0102

RIG_SCORE: 0.5041

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1876L	TCGA-22-5473	LUSC	TCGA	PPTPAPE	DEG_SCF_FBW7_2	0.1389
p.F1876L	DO26467	LUSC	ICGC	PPTPAPE	DEG_SCF_FBW7_2	0.1389
p.P1854A	TCGA-DJ-A3VA	THCA	TCGA	PPTPAPE	DEG_SCF_FBW7_2	0.0833
p.P1854A	DO40286	THCA	ICGC	PPTPAPE	DEG_SCF_FBW7_2	0.0833
p.P1866H	TCGA-DU-6392	LGG	TCGA	PPTPAPE	DEG_SCF_FBW7_2	0.7694
p.P1866H	DO22237	LGG	ICGC	PPTPAPE	DEG_SCF_FBW7_2	0.7694
p.P1859Q	TCGA-GN-A262	SKCM	TCGA	PPTPAPE	DEG_SCF_FBW7_2	0.2222
p.P1859Q	DO37515	SKCM	ICGC	PPTPAPE	DEG_SCF_FBW7_2	0.2222
p.P1864S	DO230500	PRAD	ICGC	PPTPAPE	DEG_SCF_FBW7_2	0.5641
p.A1871P	ACH-000978	Endometrial/Uterine Cancer	CCLE	PPTPAPE	DEG_SCF_FBW7_2	0.2778
p.A1871P	EN	endometrium	COSMIC	PPTPAPE	DEG_SCF_FBW7_2	0.2778
p.E1873A	ACH-000993	Endometrial/Uterine Cancer	CCLE	PPTPAPE	DEG_SCF_FBW7_2	0.2222
p.G1869D	OCUB-M	breast	COSMIC	PPTPAPE	DEG_SCF_FBW7_2	0.7198
p.G1869D	LNCaP-Clone-FGC	prostate	COSMIC	PPTPAPE	DEG_SCF_FBW7_2	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14651	Homeobox protein Hox-B3	DEG_SCF_FBW7_2	322:328	PPTPAPE	FBXW7	0.9919	More...
P78559	Microtubule-associated protein 1A	DEG_SCF_FBW7_2	1863:1869	PPTPAPE	FBXW7	0.977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons