DegronMD

Uniprot ID: P14651

Source protein: Homeobox protein Hox-B3

Source gene: HOXB3

Class: DEG_SCF_FBW7_2

Location: 322:328

E3 ligase: FBXW7

DEGRON score: 0.9919

ASA_SCORE: 77.3143

COIL: 0.9453

CONS_SCORE: 0.4869

DSS_SCORE: 0.5793

HELIX: 0.0223

FCONS_SCORE: 0.8513

RIG_SCORE: 0.6241

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q319K	TCGA-49-AARE	LUAD	TCGA	PPTPAPE	DEG_SCF_FBW7_2	0.25
p.Q319K	DO218922	LUAD	ICGC	PPTPAPE	DEG_SCF_FBW7_2	0.25
p.Q335K	TCGA-78-7540	LUAD	TCGA	PPTPAPE	DEG_SCF_FBW7_2	0.1389
p.Q335K	DO23810	LUAD	ICGC	PPTPAPE	DEG_SCF_FBW7_2	0.1389
p.V333I	TCGA-AX-A2HC	UCEC	TCGA	PPTPAPE	DEG_SCF_FBW7_2	0.1944
p.V333I	TCGA-F2-A7TX	PAAD	TCGA	PPTPAPE	DEG_SCF_FBW7_2	0.1944
p.V333I	TCGA-HJ-7597	STAD	TCGA	PPTPAPE	DEG_SCF_FBW7_2	0.1944
p.V333I	DO50254	PAAD	ICGC	PPTPAPE	DEG_SCF_FBW7_2	0.1944
p.V333I	DO38195	STAD	ICGC	PPTPAPE	DEG_SCF_FBW7_2	0.1944
p.V333I	DO41572	UCEC	ICGC	PPTPAPE	DEG_SCF_FBW7_2	0.1944
p.P322H	TCGA-EB-A5UL	SKCM	TCGA	PPTPAPE	DEG_SCF_FBW7_2	0.7694
p.P322H	DO47601	SKCM	ICGC	PPTPAPE	DEG_SCF_FBW7_2	0.7694
p.A317V	SIDM00061	Ovarian Carcinoma	GDSC	PPTPAPE	DEG_SCF_FBW7_2	0.1944
p.G314C	SIDM00282	Colorectal Carcinoma	GDSC	PPTPAPE	DEG_SCF_FBW7_2	0.1111
p.G314C	CW-2	large_intestine	COSMIC	PPTPAPE	DEG_SCF_FBW7_2	0.1111
p.E328K	SIDM00217	Colorectal Carcinoma	GDSC	PPTPAPE	DEG_SCF_FBW7_2	0.7022
p.E328K	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PPTPAPE	DEG_SCF_FBW7_2	0.7022
p.E328K	SNU-1040	large_intestine	COSMIC	PPTPAPE	DEG_SCF_FBW7_2	0.7022
p.E328K	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPAPE	DEG_SCF_FBW7_2	0.7022
p.C315Y	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PPTPAPE	DEG_SCF_FBW7_2	0.1389
p.C315Y	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPAPE	DEG_SCF_FBW7_2	0.1389
p.D312Y	ACH-002144	Lung Cancer	CCLE	PPTPAPE	DEG_SCF_FBW7_2	0.0556
p.D312Y	IST-SL1	lung	COSMIC	PPTPAPE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14651	Homeobox protein Hox-B3	DEG_SCF_FBW7_2	322:328	PPTPAPE	FBXW7	0.9919	More...
P78559	Microtubule-associated protein 1A	DEG_SCF_FBW7_2	1863:1869	PPTPAPE	FBXW7	0.977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons