DegronMD - P14651(HOXB3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q319K	TCGA-49-AARE	LUAD	TCGA	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation rewiring degron network	0.25
p.Q319K	DO218922	LUAD	ICGC	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation rewiring degron network	0.25
p.M282I	TCGA-64-5779	LUAD	TCGA	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation altering degron motif	0.6507
p.M282I	DO24930	LUAD	ICGC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation altering degron motif	0.6507
p.Q335K	TCGA-78-7540	LUAD	TCGA	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation rewiring degron network	0.1389
p.Q335K	DO23810	LUAD	ICGC	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation rewiring degron network	0.1389
p.V333I	TCGA-AX-A2HC	UCEC	TCGA	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation rewiring degron network	0.1944
p.V333I	TCGA-F2-A7TX	PAAD	TCGA	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation rewiring degron network	0.1944
p.V333I	TCGA-HJ-7597	STAD	TCGA	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation rewiring degron network	0.1944
p.V333I	DO50254	PAAD	ICGC	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation rewiring degron network	0.1944
p.V333I	DO38195	STAD	ICGC	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation rewiring degron network	0.1944
p.V333I	DO41572	UCEC	ICGC	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation rewiring degron network	0.1944
p.T272M	TCGA-CG-4465	STAD	TCGA	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.0556
p.T272M	DO38627	STAD	ICGC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.0556
p.T272M	SIDM00505	Pancreatic Carcinoma	GDSC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.0556
p.T272M	SIDM01664	Prostate Carcinoma	GDSC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.0556
p.T272M	MIA-PaCa-2	pancreas	COSMIC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.0556
p.P322H	TCGA-EB-A5UL	SKCM	TCGA	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation altering degron motif	0.7694
p.P322H	DO47601	SKCM	ICGC	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation altering degron motif	0.7694
p.A278T	TCGA-F4-6570	COAD	TCGA	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.2222
p.A278T	DO10443	COAD	ICGC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.2222
p.A278T	DO233864	GACA	ICGC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.2222
p.E287K	TCGA-R6-A6KZ	ESCA	TCGA	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation altering degron motif	0.7022
p.E287K	DO228514	PRAD	ICGC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation altering degron motif	0.7022
p.P292L	DO222404	BTCA	ICGC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.1944
p.A278V	DO232224	PBCA	ICGC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.2222
p.A317V	SIDM00061	Ovarian Carcinoma	GDSC	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation rewiring degron network	0.1944
p.E287D	SIDM00845	Burkitt's Lymphoma	GDSC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation altering degron motif	0.6758
p.E287D	SIDM00461	Acute Myeloid Leukemia	GDSC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation altering degron motif	0.6758
p.E287D	SIDM00946	T-Lymphoblastic Leukemia	GDSC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation altering degron motif	0.6758
p.E287D	SIDM01519	Head and Neck Carcinoma	GDSC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation altering degron motif	0.6758
p.S288C	SIDM00712	Non-Cancerous	GDSC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.3056
p.S288C	SIDM00713	Mesothelioma	GDSC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.3056
p.S288C	ACH-000153	Lung Cancer	CCLE	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.3056
p.G314C	SIDM00282	Colorectal Carcinoma	GDSC	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation rewiring degron network	0.1111
p.G314C	CW-2	large intestine	COSMIC	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation rewiring degron network	0.1111
p.P284S	SIDM00609	Kidney Carcinoma	GDSC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation altering degron motif	0.6752
p.P284S	SIDM00381	Cervical Carcinoma	GDSC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation altering degron motif	0.6752
p.P284S	SIDM01033	Bladder Carcinoma	GDSC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation altering degron motif	0.6752
p.P284S	SIDM00359	Colorectal Carcinoma	GDSC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation altering degron motif	0.6752
p.P284S	KMRC-20	kidney	COSMIC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation altering degron motif	0.6752
p.P284S	KU-19-19	urinary tract	COSMIC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation altering degron motif	0.6752
p.P284S	SKG-IIIa	cervix	COSMIC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation altering degron motif	0.6752
p.P284S	RCM-1	large intestine	COSMIC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation altering degron motif	0.6752
p.E328K	SIDM00217	Colorectal Carcinoma	GDSC	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation altering degron motif	0.7022
p.E328K	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation altering degron motif	0.7022
p.E328K	SNU-1040	large intestine	COSMIC	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation altering degron motif	0.7022
p.E328K	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation altering degron motif	0.7022
p.C315Y	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation rewiring degron network	0.1389
p.C315Y	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation rewiring degron network	0.1389
p.P277L	ACH-000874	Leukemia	CCLE	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.1944
p.P277L	ACH-002309	Sarcoma	CCLE	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.1944
p.P277L	SW684	soft tissue	COSMIC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.1944
p.P277L	RS4-11	haematopoietic and lymphoid tissue	COSMIC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.1944
p.Q274H	ACH-001367	Neuroblastoma	CCLE	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.1111
p.L297V	ACH-001623	Brain Cancer	CCLE	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.0556
p.D312Y	ACH-002144	Lung Cancer	CCLE	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation rewiring degron network	0.0556
p.D312Y	IST-SL1	lung	COSMIC	PPTPAPE	DEG_SCF_FBW7_2	322:328	Mutation rewiring degron network	0.0556
p.G294D	ACH-002166	Skin Cancer	CCLE	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.1389
p.G294D	MZ7-mel	skin	COSMIC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.1389
p.T272N	ACH-002222	Leukemia	CCLE	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.0556
p.T272N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.0556
p.A283V	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation altering degron motif	0.6936
p.G288A	HMV-II	skin	COSMIC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.3056
p.G286A	HMV-II	skin	COSMIC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation altering degron motif	0.754
p.A281V	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	MTPSYE	DEG_SCF_FBW7_2	282:287	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HOXB3

UniProt ID: P14651

Entrez ID: 3213

Protein name: Homeobox protein Hox-B3 (Homeobox protein Hox-2.7) (Homeobox protein Hox-2G)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HOXB3 in