DegronMD

Uniprot ID: P14651

Source protein: Homeobox protein Hox-B3

Source gene: HOXB3

Class: DEG_SCF_FBW7_2

Location: 282:287

E3 ligase: FBXW7

DEGRON score: 0.7809

ASA_SCORE: 89

COIL: 0.9188

CONS_SCORE: 0.5019

DSS_SCORE: 0.5417

HELIX: 0.0477

FCONS_SCORE: 0.8394

RIG_SCORE: 0.6078

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M282I	TCGA-64-5779	LUAD	TCGA	MTPSYE	DEG_SCF_FBW7_2	0.6507
p.M282I	DO24930	LUAD	ICGC	MTPSYE	DEG_SCF_FBW7_2	0.6507
p.T272M	TCGA-CG-4465	STAD	TCGA	MTPSYE	DEG_SCF_FBW7_2	0.0556
p.T272M	DO38627	STAD	ICGC	MTPSYE	DEG_SCF_FBW7_2	0.0556
p.T272M	SIDM00505	Pancreatic Carcinoma	GDSC	MTPSYE	DEG_SCF_FBW7_2	0.0556
p.T272M	SIDM01664	Prostate Carcinoma	GDSC	MTPSYE	DEG_SCF_FBW7_2	0.0556
p.T272M	MIA-PaCa-2	pancreas	COSMIC	MTPSYE	DEG_SCF_FBW7_2	0.0556
p.A278T	TCGA-F4-6570	COAD	TCGA	MTPSYE	DEG_SCF_FBW7_2	0.2222
p.A278T	DO10443	COAD	ICGC	MTPSYE	DEG_SCF_FBW7_2	0.2222
p.A278T	DO233864	GACA	ICGC	MTPSYE	DEG_SCF_FBW7_2	0.2222
p.E287K	TCGA-R6-A6KZ	ESCA	TCGA	MTPSYE	DEG_SCF_FBW7_2	0.7022
p.E287K	DO228514	PRAD	ICGC	MTPSYE	DEG_SCF_FBW7_2	0.7022
p.P292L	DO222404	BTCA	ICGC	MTPSYE	DEG_SCF_FBW7_2	0.1944
p.A278V	DO232224	PBCA	ICGC	MTPSYE	DEG_SCF_FBW7_2	0.2222
p.E287D	SIDM00845	Burkitt's Lymphoma	GDSC	MTPSYE	DEG_SCF_FBW7_2	0.6758
p.E287D	SIDM00461	Acute Myeloid Leukemia	GDSC	MTPSYE	DEG_SCF_FBW7_2	0.6758
p.E287D	SIDM00946	T-Lymphoblastic Leukemia	GDSC	MTPSYE	DEG_SCF_FBW7_2	0.6758
p.E287D	SIDM01519	Head and Neck Carcinoma	GDSC	MTPSYE	DEG_SCF_FBW7_2	0.6758
p.S288C	SIDM00712	Non-Cancerous	GDSC	MTPSYE	DEG_SCF_FBW7_2	0.3056
p.S288C	SIDM00713	Mesothelioma	GDSC	MTPSYE	DEG_SCF_FBW7_2	0.3056
p.S288C	ACH-000153	Lung Cancer	CCLE	MTPSYE	DEG_SCF_FBW7_2	0.3056
p.P284S	SIDM00609	Kidney Carcinoma	GDSC	MTPSYE	DEG_SCF_FBW7_2	0.6752
p.P284S	SIDM00381	Cervical Carcinoma	GDSC	MTPSYE	DEG_SCF_FBW7_2	0.6752
p.P284S	SIDM01033	Bladder Carcinoma	GDSC	MTPSYE	DEG_SCF_FBW7_2	0.6752
p.P284S	SIDM00359	Colorectal Carcinoma	GDSC	MTPSYE	DEG_SCF_FBW7_2	0.6752
p.P284S	KMRC-20	kidney	COSMIC	MTPSYE	DEG_SCF_FBW7_2	0.6752
p.P284S	KU-19-19	urinary_tract	COSMIC	MTPSYE	DEG_SCF_FBW7_2	0.6752
p.P284S	SKG-IIIa	cervix	COSMIC	MTPSYE	DEG_SCF_FBW7_2	0.6752
p.P284S	RCM-1	large_intestine	COSMIC	MTPSYE	DEG_SCF_FBW7_2	0.6752
p.P277L	ACH-000874	Leukemia	CCLE	MTPSYE	DEG_SCF_FBW7_2	0.1944
p.P277L	ACH-002309	Sarcoma	CCLE	MTPSYE	DEG_SCF_FBW7_2	0.1944
p.P277L	SW684	soft_tissue	COSMIC	MTPSYE	DEG_SCF_FBW7_2	0.1944
p.P277L	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	MTPSYE	DEG_SCF_FBW7_2	0.1944
p.Q274H	ACH-001367	Neuroblastoma	CCLE	MTPSYE	DEG_SCF_FBW7_2	0.1111
p.L297V	ACH-001623	Brain Cancer	CCLE	MTPSYE	DEG_SCF_FBW7_2	0.0556
p.G294D	ACH-002166	Skin Cancer	CCLE	MTPSYE	DEG_SCF_FBW7_2	0.1389
p.G294D	MZ7-mel	skin	COSMIC	MTPSYE	DEG_SCF_FBW7_2	0.1389
p.T272N	ACH-002222	Leukemia	CCLE	MTPSYE	DEG_SCF_FBW7_2	0.0556
p.T272N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	MTPSYE	DEG_SCF_FBW7_2	0.0556
p.A283V	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	MTPSYE	DEG_SCF_FBW7_2	0.6936
p.G288A	HMV-II	skin	COSMIC	MTPSYE	DEG_SCF_FBW7_2	0.3056
p.G286A	HMV-II	skin	COSMIC	MTPSYE	DEG_SCF_FBW7_2	0.754
p.A281V	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	MTPSYE	DEG_SCF_FBW7_2	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MTPSYE

Degron related mutations and impact score

Drug responses associated with HOXB3 mutations

All proteins holding degron of MTPSYE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14651	Homeobox protein Hox-B3	DEG_SCF_FBW7_2	282:287	MTPSYE	FBXW7	0.7809	More...