DegronMD

Uniprot ID: P78559

Source protein: Microtubule-associated protein 1A

Source gene: MAP1A

Class: DEG_COP1_1

Location: 1928:1937

E3 ligase: COP1

DEGRON score: 0.8441

ASA_SCORE: 97.63

COIL: 0.9373

CONS_SCORE: 0.5301

DSS_SCORE: 0.7791

HELIX: 0.035

FCONS_SCORE: 1.0511

RIG_SCORE: 0.4945

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1942V	TCGA-AA-A010	COAD	TCGA	SSHSSKVPEA	DEG_COP1_1	0.1944
p.S1940N	TCGA-FW-A3R5	SKCM	TCGA	SSHSSKVPEA	DEG_COP1_1	0.25
p.S1940N	DO37406	SKCM	ICGC	SSHSSKVPEA	DEG_COP1_1	0.25
p.R1921K	TCGA-T3-A92M	HNSC	TCGA	SSHSSKVPEA	DEG_COP1_1	0.1389
p.R1921K	DO223269	HNSC	ICGC	SSHSSKVPEA	DEG_COP1_1	0.1389
p.T1944K	TCGA-VR-A8EX	ESCA	TCGA	SSHSSKVPEA	DEG_COP1_1	0.1389
p.K1927E	DO230334	COCA	ICGC	SSHSSKVPEA	DEG_COP1_1	0.3056
p.E1945D	DO229028	LICA	ICGC	SSHSSKVPEA	DEG_COP1_1	0.1111
p.P1925H	DO228253	MALY	ICGC	SSHSSKVPEA	DEG_COP1_1	0.25
p.R1942W	ACH-000895	Colon/Colorectal Cancer	CCLE	SSHSSKVPEA	DEG_COP1_1	0.1944
p.R1942W	CL-34	large_intestine	COSMIC	SSHSSKVPEA	DEG_COP1_1	0.1944
p.E1937K	ACH-000968	Skin Cancer	CCLE	SSHSSKVPEA	DEG_COP1_1	0.7022
p.E1937K	COLO-792	skin	COSMIC	SSHSSKVPEA	DEG_COP1_1	0.7022
p.R1924I	ACH-002272	Lymphoma	CCLE	SSHSSKVPEA	DEG_COP1_1	0.2222
p.R1924I	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	SSHSSKVPEA	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78559	Microtubule-associated protein 1A	DEG_COP1_1	1928:1937	SSHSSKVPEA	COP1	0.8441	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons