DegronMD

Uniprot ID: P78559

Source protein: Microtubule-associated protein 1A

Source gene: MAP1A

Class: DEG_SCF_FBW7_1

Location: 1316:1322

E3 ligase: FBXW7

DEGRON score: 0.9432

ASA_SCORE: 83.0286

COIL: 0.8019

CONS_SCORE: 0.4748

DSS_SCORE: 0.6419

HELIX: 0.0806

FCONS_SCORE: 0.8818

RIG_SCORE: 0.6848

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1317S	ACH-000764	Gastric Cancer	CCLE	ILTPDSS	DEG_SCF_FBW7_1	0.7341
p.L1317P	TCGA-BR-6452	STAD	TCGA	ILTPDSS	DEG_SCF_FBW7_1	0.6471
p.L1317P	DO38404	STAD	ICGC	ILTPDSS	DEG_SCF_FBW7_1	0.6471
p.L1317V	TCGA-BR-7901	STAD	TCGA	ILTPDSS	DEG_SCF_FBW7_1	0.5654
p.L1317V	DO38463	STAD	ICGC	ILTPDSS	DEG_SCF_FBW7_1	0.5654
p.S1324Y	TCGA-BF-A1PX	SKCM	TCGA	ILTPDSS	DEG_SCF_FBW7_1	0.2778
p.S1324Y	DO51236	SKCM	ICGC	ILTPDSS	DEG_SCF_FBW7_1	0.2778
p.E1314K	TCGA-DC-6683	READ	TCGA	ILTPDSS	DEG_SCF_FBW7_1	0.2778
p.E1314K	DO37018	READ	ICGC	ILTPDSS	DEG_SCF_FBW7_1	0.2778
p.P1312R	SIDM00882	Breast Carcinoma	GDSC	ILTPDSS	DEG_SCF_FBW7_1	0.2222
p.P1312R	HCC1419	breast	COSMIC	ILTPDSS	DEG_SCF_FBW7_1	0.2222
p.P1327L	TCGA-AA-3663	COAD	TCGA	ILTPDSS	DEG_SCF_FBW7_1	0.1944
p.P1327L	DO9346	COAD	ICGC	ILTPDSS	DEG_SCF_FBW7_1	0.1944
p.P1327S	TCGA-YG-AA3N	SKCM	TCGA	ILTPDSS	DEG_SCF_FBW7_1	0.1944
p.P1327S	DO51298	SKCM	ICGC	ILTPDSS	DEG_SCF_FBW7_1	0.1944
p.T1310I	DO234189	ESAD	ICGC	ILTPDSS	DEG_SCF_FBW7_1	0.1667
p.L1330V	TCGA-Z2-AA3V	SKCM	TCGA	ILTPDSS	DEG_SCF_FBW7_1	0.1111
p.L1330V	DO51303	SKCM	ICGC	ILTPDSS	DEG_SCF_FBW7_1	0.1111
p.P1331S	DO233267	GACA	ICGC	ILTPDSS	DEG_SCF_FBW7_1	0.0833
p.A1331T	ACH-000988	Endometrial/Uterine Cancer	CCLE	ILTPDSS	DEG_SCF_FBW7_1	0.0833
p.A1331T	MFE-319	endometrium	COSMIC	ILTPDSS	DEG_SCF_FBW7_1	0.0833
p.G1332V	DO233898	GACA	ICGC	ILTPDSS	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78559	Microtubule-associated protein 1A	DEG_SCF_FBW7_1	1316:1322	ILTPDSS	FBXW7	0.9432	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons