DegronMD

Uniprot ID: P78559

Source protein: Microtubule-associated protein 1A

Source gene: MAP1A

Class: DEG_SCF_TRCP1_1

Location: 611:616

E3 ligase: BTRC

DEGRON score: 0.9992

ASA_SCORE: 77.7833

COIL: 0.8447

CONS_SCORE: 0.5549

DSS_SCORE: 0.7447

HELIX: 0.1245

FCONS_SCORE: 1.1295

RIG_SCORE: 0.5786

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S605N	TCGA-AP-A1DK	UCEC	TCGA	DSGAET	DEG_SCF_TRCP1_1	0.6111
p.S605N	DO42033	UCEC	ICGC	DSGAET	DEG_SCF_TRCP1_1	0.6111
p.D621Y	TCGA-AX-A05Z	UCEC	TCGA	DSGAET	DEG_SCF_TRCP1_1	0.1944
p.D621Y	DO40884	UCEC	ICGC	DSGAET	DEG_SCF_TRCP1_1	0.1944
p.T622I	TCGA-FR-A729	SKCM	TCGA	DSGAET	DEG_SCF_TRCP1_1	0.6111
p.T622I	DO48618	SKCM	ICGC	DSGAET	DEG_SCF_TRCP1_1	0.6111
p.E601K	SIDM01190	Bladder Carcinoma	GDSC	DSGAET	DEG_SCF_TRCP1_1	0.0556
p.E601K	TCCSUP	urinary_tract	COSMIC	DSGAET	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78559	Microtubule-associated protein 1A	DEG_SCF_TRCP1_1	611:616	DSGAET	BTRC	0.9992	More...
Q86V42	Protein FAM124A	DEG_SCF_TRCP1_1	16:21	DSGAET	BTRC	0.8903	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons