DegronMD - Q86V42(FAM124A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L454M	TCGA-44-8120	LUAD	TCGA	VETPLPS	DEG_SCF_FBW7_1	441:447	Mutation rewiring degron network	0.1389
p.L454M	DO45402	LUAD	ICGC	VETPLPS	DEG_SCF_FBW7_1	441:447	Mutation rewiring degron network	0.1389
p.H493Y	TCGA-78-7220	LUAD	TCGA	APSTS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1389
p.H493Y	DO24409	LUAD	ICGC	APSTS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1389
p.T303M	TCGA-AF-A56L	READ	TCGA	PSHTPGSS	DEG_SCF_FBW7_1	311:318	Mutation rewiring degron network	0.1111
p.T303M	DO230336	COCA	ICGC	PSHTPGSS	DEG_SCF_FBW7_1	311:318	Mutation rewiring degron network	0.1111
p.T303M	DO218693	GACA	ICGC	PSHTPGSS	DEG_SCF_FBW7_1	311:318	Mutation rewiring degron network	0.1111
p.T303M	DO34448	PACA	ICGC	PSHTPGSS	DEG_SCF_FBW7_1	311:318	Mutation rewiring degron network	0.1111
p.T303M	DO50276	READ	ICGC	PSHTPGSS	DEG_SCF_FBW7_1	311:318	Mutation rewiring degron network	0.1111
p.L454P	TCGA-B2-4102	KIRC	TCGA	VETPLPS	DEG_SCF_FBW7_1	441:447	Mutation rewiring degron network	0.1389
p.L454P	DO18839	KIRC	ICGC	VETPLPS	DEG_SCF_FBW7_1	441:447	Mutation rewiring degron network	0.1389
p.R327T	TCGA-CQ-5331	HNSC	TCGA	PSHTPGSS	DEG_SCF_FBW7_1	311:318	Mutation rewiring degron network	0.0833
p.R327T	DO15495	HNSC	ICGC	PSHTPGSS	DEG_SCF_FBW7_1	311:318	Mutation rewiring degron network	0.0833
p.A491E	TCGA-FA-A7DS	DLBC	TCGA	APSTS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.A491E	DO219889	DLBC	ICGC	APSTS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.K320T	TCGA-VQ-A91X	STAD	TCGA	PSHTPGSS	DEG_SCF_FBW7_1	311:318	Mutation rewiring degron network	0.2778
p.K320T	DO51790	STAD	ICGC	PSHTPGSS	DEG_SCF_FBW7_1	311:318	Mutation rewiring degron network	0.2778
p.G326D	TCGA-VR-AA4D	ESCA	TCGA	PSHTPGSS	DEG_SCF_FBW7_1	311:318	Mutation rewiring degron network	0.1111
p.G6D	DO234376	ESAD	ICGC	DSGAET	DEG_SCF_TRCP1_1	16:21	Mutation rewiring degron network	0.0556
p.R455Q	DO234453	ESAD	ICGC	VETPLPS	DEG_SCF_FBW7_1	441:447	Mutation rewiring degron network	0.1111
p.R455Q	DO35757	PBCA	ICGC	VETPLPS	DEG_SCF_FBW7_1	441:447	Mutation rewiring degron network	0.1111
p.P502S	DO222477	ESCA	ICGC	APSTS	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.6752
p.G326V	DO228936	LICA	ICGC	PSHTPGSS	DEG_SCF_FBW7_1	311:318	Mutation rewiring degron network	0.1111
p.R455L	DO228971	LICA	ICGC	VETPLPS	DEG_SCF_FBW7_1	441:447	Mutation rewiring degron network	0.1111
p.S505I	DO229019	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.3056
p.P323S	DO220861	MELA	ICGC	PSHTPGSS	DEG_SCF_FBW7_1	311:318	Mutation rewiring degron network	0.1944
p.S438F	DO229446	SKCA	ICGC	VETPLPS	DEG_SCF_FBW7_1	441:447	Mutation rewiring degron network	0.25
p.D441N	SIDM01296	Esophageal Carcinoma	GDSC	VETPLPS	DEG_SCF_FBW7_1	441:447	Mutation altering degron motif	0.6932
p.R455W	SIDM00611	Kidney Carcinoma	GDSC	VETPLPS	DEG_SCF_FBW7_1	441:447	Mutation rewiring degron network	0.1111
p.A491S	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.A491S	SIDM00967	Ovarian Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.A491S	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.A491S	SIDM00493	Other Solid Cancers	GDSC	APSTS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.A491S	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.A491S	SIDM00863	Burkitt's Lymphoma	GDSC	APSTS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.A491S	SIDM01409	Bladder Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.H306Y	SIDM00007	Other Solid Cancers	GDSC	PSHTPGSS	DEG_SCF_FBW7_1	311:318	Mutation rewiring degron network	0.1944
p.H306Y	MCC13	skin	COSMIC	PSHTPGSS	DEG_SCF_FBW7_1	311:318	Mutation rewiring degron network	0.1944
p.D440N	SIDM00193	Colorectal Carcinoma	GDSC	VETPLPS	DEG_SCF_FBW7_1	441:447	Mutation rewiring degron network	0.3056
p.D440N	SNU-81	large intestine	COSMIC	VETPLPS	DEG_SCF_FBW7_1	441:447	Mutation rewiring degron network	0.3056
p.L454R	SIDM00653	Small Cell Lung Carcinoma	GDSC	VETPLPS	DEG_SCF_FBW7_1	441:447	Mutation rewiring degron network	0.1389
p.L454R	NCI-H1092	lung	COSMIC	VETPLPS	DEG_SCF_FBW7_1	441:447	Mutation rewiring degron network	0.1389
p.A492T	SIDM01619	Endometrial Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1111
p.L445F	ACH-000879	Endometrial/Uterine Cancer	CCLE	VETPLPS	DEG_SCF_FBW7_1	441:447	Mutation altering degron motif	0.587
p.L445F	MFE-296	endometrium	COSMIC	VETPLPS	DEG_SCF_FBW7_1	441:447	Mutation altering degron motif	0.587
p.A456T	ACH-000984	Endometrial/Uterine Cancer	CCLE	VETPLPS	DEG_SCF_FBW7_1	441:447	Mutation rewiring degron network	0.0833
p.E448K	ACH-001131	Skin Cancer	CCLE	VETPLPS	DEG_SCF_FBW7_1	441:447	Mutation rewiring degron network	0.3056
p.P446L	ACH-002309	Sarcoma	CCLE	VETPLPS	DEG_SCF_FBW7_1	441:447	Mutation altering degron motif	0.6471
p.P446L	SW684	soft tissue	COSMIC	VETPLPS	DEG_SCF_FBW7_1	441:447	Mutation altering degron motif	0.6471
p.P322L	KYSE-150	oesophagus	COSMIC	PSHTPGSS	DEG_SCF_FBW7_1	311:318	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM124A

UniProt ID: Q86V42

Entrez ID: 220108

Protein name: Protein FAM124A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM124A in