DegronMD

Uniprot ID: Q86V42

Source protein: Protein FAM124A

Source gene: FAM124A

Class: DEG_SCF_FBW7_1

Location: 441:447

E3 ligase: FBXW7

DEGRON score: 0.98

ASA_SCORE: 72.0143

COIL: 0.9199

CONS_SCORE: 0.2243

DSS_SCORE: 0.3325

HELIX: 0.0353

FCONS_SCORE: 1.0642

RIG_SCORE: 0.7035

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L454M	TCGA-44-8120	LUAD	TCGA	VETPLPS	DEG_SCF_FBW7_1	0.1389
p.L454M	DO45402	LUAD	ICGC	VETPLPS	DEG_SCF_FBW7_1	0.1389
p.L454P	TCGA-B2-4102	KIRC	TCGA	VETPLPS	DEG_SCF_FBW7_1	0.1389
p.L454P	DO18839	KIRC	ICGC	VETPLPS	DEG_SCF_FBW7_1	0.1389
p.R455Q	DO234453	ESAD	ICGC	VETPLPS	DEG_SCF_FBW7_1	0.1111
p.R455Q	DO35757	PBCA	ICGC	VETPLPS	DEG_SCF_FBW7_1	0.1111
p.R455L	DO228971	LICA	ICGC	VETPLPS	DEG_SCF_FBW7_1	0.1111
p.S438F	DO229446	SKCA	ICGC	VETPLPS	DEG_SCF_FBW7_1	0.25
p.D441N	SIDM01296	Esophageal Carcinoma	GDSC	VETPLPS	DEG_SCF_FBW7_1	0.6932
p.R455W	SIDM00611	Kidney Carcinoma	GDSC	VETPLPS	DEG_SCF_FBW7_1	0.1111
p.D440N	SIDM00193	Colorectal Carcinoma	GDSC	VETPLPS	DEG_SCF_FBW7_1	0.3056
p.D440N	SNU-81	large_intestine	COSMIC	VETPLPS	DEG_SCF_FBW7_1	0.3056
p.L454R	SIDM00653	Small Cell Lung Carcinoma	GDSC	VETPLPS	DEG_SCF_FBW7_1	0.1389
p.L454R	NCI-H1092	lung	COSMIC	VETPLPS	DEG_SCF_FBW7_1	0.1389
p.L445F	ACH-000879	Endometrial/Uterine Cancer	CCLE	VETPLPS	DEG_SCF_FBW7_1	0.587
p.L445F	MFE-296	endometrium	COSMIC	VETPLPS	DEG_SCF_FBW7_1	0.587
p.A456T	ACH-000984	Endometrial/Uterine Cancer	CCLE	VETPLPS	DEG_SCF_FBW7_1	0.0833
p.E448K	ACH-001131	Skin Cancer	CCLE	VETPLPS	DEG_SCF_FBW7_1	0.3056
p.P446L	ACH-002309	Sarcoma	CCLE	VETPLPS	DEG_SCF_FBW7_1	0.6471
p.P446L	SW684	soft_tissue	COSMIC	VETPLPS	DEG_SCF_FBW7_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86V42	Protein FAM124A	DEG_SCF_FBW7_1	441:447	VETPLPS	FBXW7	0.98	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons