DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSGAET
Uniprot ID:
Q86V42
Source protein:
Protein FAM124A
Source gene:
FAM124A
Class:
DEG_SCF_TRCP1_1
Location:
16:21
E3 ligase:
BTRC
DEGRON score:
0.8903
ASA_SCORE:
71.4
COIL:
0.7707
CONS_SCORE:
0.4905
DSS_SCORE:
0.6699
HELIX:
0.1445
FCONS_SCORE:
1.014
RIG_SCORE:
0.6218
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G6D
DO234376
ESAD
ICGC
DSGAET
DEG_SCF_TRCP1_1
0.0556
Drug responses associated with FAM124A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGAET
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P78559
Microtubule-associated protein 1A
DEG_SCF_TRCP1_1
611:616
DSGAET
BTRC
0.9992
More...
Q86V42
Protein FAM124A
DEG_SCF_TRCP1_1
16:21
DSGAET
BTRC
0.8903
More...