DegronMD

Uniprot ID: Q86V42

Source protein: Protein FAM124A

Source gene: FAM124A

Class: DEG_SCF_FBW7_1

Location: 311:318

E3 ligase: FBXW7

DEGRON score: 0.9715

ASA_SCORE: 85.3125

COIL: 0.9586

CONS_SCORE: 0.2979

DSS_SCORE: 0.8444

HELIX: 0.0224

FCONS_SCORE: 1.0027

RIG_SCORE: 0.4997

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T303M	TCGA-AF-A56L	READ	TCGA	PSHTPGSS	DEG_SCF_FBW7_1	0.1111
p.T303M	DO230336	COCA	ICGC	PSHTPGSS	DEG_SCF_FBW7_1	0.1111
p.T303M	DO218693	GACA	ICGC	PSHTPGSS	DEG_SCF_FBW7_1	0.1111
p.T303M	DO34448	PACA	ICGC	PSHTPGSS	DEG_SCF_FBW7_1	0.1111
p.T303M	DO50276	READ	ICGC	PSHTPGSS	DEG_SCF_FBW7_1	0.1111
p.R327T	TCGA-CQ-5331	HNSC	TCGA	PSHTPGSS	DEG_SCF_FBW7_1	0.0833
p.R327T	DO15495	HNSC	ICGC	PSHTPGSS	DEG_SCF_FBW7_1	0.0833
p.K320T	TCGA-VQ-A91X	STAD	TCGA	PSHTPGSS	DEG_SCF_FBW7_1	0.2778
p.K320T	DO51790	STAD	ICGC	PSHTPGSS	DEG_SCF_FBW7_1	0.2778
p.G326D	TCGA-VR-AA4D	ESCA	TCGA	PSHTPGSS	DEG_SCF_FBW7_1	0.1111
p.G326V	DO228936	LICA	ICGC	PSHTPGSS	DEG_SCF_FBW7_1	0.1111
p.P323S	DO220861	MELA	ICGC	PSHTPGSS	DEG_SCF_FBW7_1	0.1944
p.H306Y	SIDM00007	Other Solid Cancers	GDSC	PSHTPGSS	DEG_SCF_FBW7_1	0.1944
p.H306Y	MCC13	skin	COSMIC	PSHTPGSS	DEG_SCF_FBW7_1	0.1944
p.P322L	KYSE-150	oesophagus	COSMIC	PSHTPGSS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86V42	Protein FAM124A	DEG_SCF_FBW7_1	311:318	PSHTPGSS	FBXW7	0.9715	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons