DegronMD

Uniprot ID: P78559

Source protein: Microtubule-associated protein 1A

Source gene: MAP1A

Class: DEG_COP1_1

Location: 1151:1161

E3 ligase: COP1

DEGRON score: 0.9862

ASA_SCORE: 86.8364

COIL: 0.8217

CONS_SCORE: 0.5807

DSS_SCORE: 0.6958

HELIX: 0.1482

FCONS_SCORE: 1.0522

RIG_SCORE: 0.6338

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1160P	IM-95	stomach	COSMIC	ESLSVLSVPSP	DEG_COP1_1	0.7863
p.T1163I	TCGA-AX-A06F	UCEC	TCGA	ESLSVLSVPSP	DEG_COP1_1	0.7222
p.T1163I	DO41752	UCEC	ICGC	ESLSVLSVPSP	DEG_COP1_1	0.7222
p.V1158M	SIDM01220	Glioma	GDSC	ESLSVLSVPSP	DEG_COP1_1	0.7208
p.V1158M	LNZTA3WT4	central_nervous_system	COSMIC	ESLSVLSVPSP	DEG_COP1_1	0.7208
p.T1156I	ACH-000994	Endometrial/Uterine Cancer	CCLE	ESLSVLSVPSP	DEG_COP1_1	0.7078
p.F1153L	ACH-000996	Endometrial/Uterine Cancer	CCLE	ESLSVLSVPSP	DEG_COP1_1	0.6981
p.V1158L	DO229008	LICA	ICGC	ESLSVLSVPSP	DEG_COP1_1	0.6765
p.D1152E	HuP-T4	pancreas	COSMIC	ESLSVLSVPSP	DEG_COP1_1	0.6758
p.P1161S	ACH-002396	Bone Cancer	CCLE	ESLSVLSVPSP	DEG_COP1_1	0.6752
p.P1161S	Sarc9371	bone	COSMIC	ESLSVLSVPSP	DEG_COP1_1	0.6752
p.V1155F	DO229037	LICA	ICGC	ESLSVLSVPSP	DEG_COP1_1	0.5957
p.P1147A	SIDM00675	Breast Carcinoma	GDSC	ESLSVLSVPSP	DEG_COP1_1	0.2222
p.P1147A	HCC38	breast	COSMIC	ESLSVLSVPSP	DEG_COP1_1	0.2222
p.I1165T	ACH-000390	Lung Cancer	CCLE	ESLSVLSVPSP	DEG_COP1_1	0.2222
p.K1171N	TCGA-AP-A1DV	UCEC	TCGA	ESLSVLSVPSP	DEG_COP1_1	0.1667
p.K1171N	DO43186	UCEC	ICGC	ESLSVLSVPSP	DEG_COP1_1	0.1667
p.R1143Q	TCGA-90-A4ED	LUSC	TCGA	ESLSVLSVPSP	DEG_COP1_1	0.1111
p.R1143Q	TCGA-EE-A2MR	SKCM	TCGA	ESLSVLSVPSP	DEG_COP1_1	0.1111
p.R1143Q	DO45482	LUSC	ICGC	ESLSVLSVPSP	DEG_COP1_1	0.1111
p.R1143Q	DO37819	SKCM	ICGC	ESLSVLSVPSP	DEG_COP1_1	0.1111
p.P1170L	DO50970	LICA	ICGC	ESLSVLSVPSP	DEG_COP1_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78559	Microtubule-associated protein 1A	DEG_COP1_1	1151:1161	ESLSVLSVPSP	COP1	0.9862	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons