DegronMD

Uniprot ID: P78559

Source protein: Microtubule-associated protein 1A

Source gene: MAP1A

Class: DEG_SCF_FBW7_2

Location: 801:808

E3 ligase: FBXW7

DEGRON score: 0.5388

ASA_SCORE: 94.675

COIL: 0.8806

CONS_SCORE: 0.5641

DSS_SCORE: 0.4806

HELIX: 0.032

FCONS_SCORE: 1.0202

RIG_SCORE: 0.7113

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D791N	TCGA-AX-A06F	UCEC	TCGA	VYGTPETE	DEG_SCF_FBW7_2	0.0556
p.D791N	DO41752	UCEC	ICGC	VYGTPETE	DEG_SCF_FBW7_2	0.0556
p.G799D	DO229216	THCA	ICGC	VYGTPETE	DEG_SCF_FBW7_2	0.2778
p.P812A	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	VYGTPETE	DEG_SCF_FBW7_2	0.2222
p.P812A	NCI-H1299	lung	COSMIC	VYGTPETE	DEG_SCF_FBW7_2	0.2222
p.P798S	ACH-000624	Breast Cancer	CCLE	VYGTPETE	DEG_SCF_FBW7_2	0.25
p.P798S	ACH-000856	Breast Cancer	CCLE	VYGTPETE	DEG_SCF_FBW7_2	0.25
p.P798S	CAL-51	breast	COSMIC	VYGTPETE	DEG_SCF_FBW7_2	0.25
p.P798S	HCC1806	breast	COSMIC	VYGTPETE	DEG_SCF_FBW7_2	0.25
p.D794N	ACH-000677	Lung Cancer	CCLE	VYGTPETE	DEG_SCF_FBW7_2	0.1389
p.D794N	SW1573	lung	COSMIC	VYGTPETE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78559	Microtubule-associated protein 1A	DEG_SCF_FBW7_2	801:808	VYGTPETE	FBXW7	0.5388	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons