DegronMD

Uniprot ID: Q6IQ55

Source protein: Tau-tubulin kinase 2

Source gene: TTBK2

Class: DEG_SPOP_SBC_1

Location: 1122:1126

E3 ligase: SPOP

DEGRON score: 0.5437

ASA_SCORE: 97.32

COIL: 0.9104

CONS_SCORE: 0.3873

DSS_SCORE: 0.7843

HELIX: 0.0436

FCONS_SCORE: 0.9352

RIG_SCORE: 0.5889

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1119Y	TCGA-AP-A1DV	UCEC	TCGA	PRSTT	DEG_SPOP_SBC_1	0.25
p.S1119Y	DO43186	UCEC	ICGC	PRSTT	DEG_SPOP_SBC_1	0.25
p.S1119Y	SIDM01587	Bladder Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.25
p.S1119Y	ACH-000753	Bladder Cancer	CCLE	PRSTT	DEG_SPOP_SBC_1	0.25
p.S1130R	TCGA-DD-AADK	LIHC	TCGA	PRSTT	DEG_SPOP_SBC_1	0.2222
p.S1130R	DO52235	LIHC	ICGC	PRSTT	DEG_SPOP_SBC_1	0.2222
p.P1131L	TCGA-GF-A6C9	SKCM	TCGA	PRSTT	DEG_SPOP_SBC_1	0.1944
p.P1131L	DO51254	SKCM	ICGC	PRSTT	DEG_SPOP_SBC_1	0.1944
p.R1123Q	DO233115	GACA	ICGC	PRSTT	DEG_SPOP_SBC_1	0.6218
p.S1124R	DO233286	GACA	ICGC	PRSTT	DEG_SPOP_SBC_1	0.7427
p.S1124G	DO228196	LICA	ICGC	PRSTT	DEG_SPOP_SBC_1	0.6993
p.P1122S	SIDM00845	Burkitt's Lymphoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.6752
p.Q1113H	SIDM01450	Gastric Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.0833
p.Q1113H	ACH-000898	Gastric Cancer	CCLE	PRSTT	DEG_SPOP_SBC_1	0.0833
p.V1121L	OVCAR-8	ovary	COSMIC	PRSTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01880	Immunoglobulin heavy constant delta	DEG_SPOP_SBC_1	329:333	PRSTT	SPOP	0.8106	More...
P78559	Microtubule-associated protein 1A	DEG_SPOP_SBC_1	2647:2651	PRSTT	SPOP	0.9396	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	588:592	PRSTT	SPOP	0.993	More...
Q6IQ55	Tau-tubulin kinase 2	DEG_SPOP_SBC_1	1122:1126	PRSTT	SPOP	0.5437	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	252:256	PRSTT	SPOP	0.991	More...
Q9HCU4	Cadherin EGF LAG seven-pass G-type receptor 2	DEG_SPOP_SBC_1	378:382	PRSTT	SPOP	0.8201	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons