DegronMD

Uniprot ID: Q9NYQ6

Source protein: Cadherin EGF LAG seven-pass G-type receptor 1

Source gene: CELSR1

Class: DEG_APCC_DBOX_1

Location: 2988:2996

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8626

ASA_SCORE: 62.3333

COIL: 0.4671

CONS_SCORE: 0.2912

DSS_SCORE: 0.6878

HELIX: 0.4126

FCONS_SCORE: 1.118

RIG_SCORE: 0.6866

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G2984W	TCGA-EE-A2GN	SKCM	TCGA	GRDHLNGVA	DEG_APCC_DBOX_1	0.2222
p.G2984W	DO37896	SKCM	ICGC	GRDHLNGVA	DEG_APCC_DBOX_1	0.2222
p.R2985G	TCGA-FI-A2F4	UCEC	TCGA	GRDHLNGVA	DEG_APCC_DBOX_1	0.25
p.R2985G	DO43434	UCEC	ICGC	GRDHLNGVA	DEG_APCC_DBOX_1	0.25
p.N2993K	DO229015	LICA	ICGC	GRDHLNGVA	DEG_APCC_DBOX_1	0.5806
p.R2989S	DO229041	LICA	ICGC	GRDHLNGVA	DEG_APCC_DBOX_1	0.7427
p.A3004T	DO220883	MELA	ICGC	GRDHLNGVA	DEG_APCC_DBOX_1	0.1111
p.A3004T	SIDM00596	Endometrial Carcinoma	GDSC	GRDHLNGVA	DEG_APCC_DBOX_1	0.1111
p.A3004T	ACH-001517	Endometrial/Uterine Cancer	CCLE	GRDHLNGVA	DEG_APCC_DBOX_1	0.1111
p.P2987S	DO232224	PBCA	ICGC	GRDHLNGVA	DEG_APCC_DBOX_1	0.3056
p.E2986K	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	GRDHLNGVA	DEG_APCC_DBOX_1	0.2778
p.E2986K	ACH-000562	Lung Cancer	CCLE	GRDHLNGVA	DEG_APCC_DBOX_1	0.2778
p.E2986K	HCC-78	lung	COSMIC	GRDHLNGVA	DEG_APCC_DBOX_1	0.2778
p.V2980L	SIDM00860	Head and Neck Carcinoma	GDSC	GRDHLNGVA	DEG_APCC_DBOX_1	0.1111
p.V2980L	ACH-000846	Head and Neck Cancer	CCLE	GRDHLNGVA	DEG_APCC_DBOX_1	0.1111
p.V2980L	FADU	upper_aerodigestive_tract	COSMIC	GRDHLNGVA	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYQ6	Cadherin EGF LAG seven-pass G-type receptor 1	DEG_APCC_DBOX_1	2988:2996	GRDHLNGVA	APC,CDC20,FZR1	0.8626	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons