DegronMD - Q7Z570(ZNF804A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R797K	TCGA-02-2485	GBM	TCGA	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.3056
p.R797K	DO12742	GBM	ICGC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.3056
p.R251I	TCGA-05-4382	LUAD	TCGA	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation altering degron motif	0.6991
p.R251I	DO24900	LUAD	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation altering degron motif	0.6991
p.R251I	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation altering degron motif	0.6991
p.R251I	ACH-000562	Lung Cancer	CCLE	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation altering degron motif	0.6991
p.R251I	HCC-78	lung	COSMIC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation altering degron motif	0.6991
p.E397K	TCGA-09-1674	OV	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation rewiring degron network	0.2778
p.E397K	DO31050	OV	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation rewiring degron network	0.2778
p.A804S	TCGA-17-Z049	LUAD	TCGA	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.2778
p.P401T	TCGA-21-1076	LUSC	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation altering degron motif	0.7031
p.P401T	DO26599	LUSC	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation altering degron motif	0.7031
p.P1037S	TCGA-2W-A8YY	CESC	TCGA	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.3056
p.P1037S	DO223732	CESC	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.3056
p.P1037S	DO220900	MELA	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.3056
p.Q1129K	TCGA-33-4533	LUSC	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.0556
p.Q1129K	DO27572	LUSC	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.0556
p.Q1130K	TCGA-38-4625	LUAD	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.0833
p.Q1130K	DO23952	LUAD	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.0833
p.L1035F	TCGA-38-4626	LUAD	TCGA	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation altering degron motif	0.587
p.L1035F	DO24447	LUAD	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation altering degron motif	0.587
p.R1154S	TCGA-43-7658	LUSC	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1389
p.R1154S	DO27628	LUSC	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1389
p.P808L	TCGA-44-6777	LUAD	TCGA	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.1667
p.P808L	DO23645	LUAD	ICGC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.1667
p.R1154M	TCGA-44-A479	LUAD	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1389
p.R1154M	DO23633	LUAD	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1389
p.H258Y	TCGA-49-AAR9	LUAD	TCGA	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2778
p.H258Y	DO218921	LUAD	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2778
p.E389D	TCGA-55-8203	LUAD	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation rewiring degron network	0.0556
p.E389D	DO218928	LUAD	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation rewiring degron network	0.0556
p.G245V	TCGA-55-8507	LUAD	TCGA	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2778
p.G245V	DO45412	LUAD	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2778
p.P1136T	TCGA-55-A4DG	LUAD	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.25
p.P1136T	DO26337	LUAD	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.25
p.R251G	TCGA-56-A5DS	LUSC	TCGA	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation altering degron motif	0.6457
p.R251G	DO45494	LUSC	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation altering degron motif	0.6457
p.P1157H	TCGA-63-7021	LUSC	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.0556
p.P1157H	DO26782	LUSC	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.0556
p.P396T	TCGA-66-2759	LUSC	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation rewiring degron network	0.25
p.P396T	DO27326	LUSC	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation rewiring degron network	0.25
p.A240S	TCGA-85-8276	LUSC	TCGA	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.1389
p.A240S	DO26436	LUSC	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.1389
p.L1138I	TCGA-85-A4JB	LUSC	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.3056
p.L1138I	DO45517	LUSC	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.3056
p.V407F	TCGA-86-7714	LUAD	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation altering degron motif	0.5957
p.V407F	DO24870	LUAD	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation altering degron motif	0.5957
p.G395C	TCGA-98-A539	LUSC	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation rewiring degron network	0.2222
p.G395C	DO52022	LUSC	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation rewiring degron network	0.2222
p.S262F	TCGA-A5-A0G2	UCEC	TCGA	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.1667
p.S262F	DO41235	UCEC	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.1667
p.R812W	TCGA-A5-A0G2	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.0556
p.R812W	TCGA-VQ-A8P2	STAD	TCGA	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.0556
p.R812W	DO34112	PACA	ICGC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.0556
p.R812W	DO51761	STAD	ICGC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.0556
p.R812W	DO41235	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.0556
p.R812W	SIDM01293	Colorectal Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.0556
p.E1039D	TCGA-AA-3864	COAD	TCGA	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.25
p.E1039D	DO8490	COAD	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.25
p.F795L	TCGA-AP-A056	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.25
p.F795L	DO50345	ESAD	ICGC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.25
p.F795L	DO43971	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.25
p.K414T	TCGA-AX-A2HC	UCEC	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation substituting flanking lysine	0.3611
p.K414T	DO41572	UCEC	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation substituting flanking lysine	0.3611
p.T801I	TCGA-AX-A2HD	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation altering degron motif	0.8189
p.T801I	DO42608	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation altering degron motif	0.8189
p.L1132I	TCGA-AZ-4315	COAD	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1389
p.L1132I	TCGA-B5-A0JY	UCEC	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1389
p.L1132I	DO8842	COAD	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1389
p.L1132I	DO43041	UCEC	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1389
p.E397D	TCGA-B5-A3FA	UCEC	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation rewiring degron network	0.2778
p.E397D	DO52402	UCEC	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation rewiring degron network	0.2778
p.P401S	TCGA-B5-A3FA	UCEC	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation altering degron motif	0.6752
p.P401S	TCGA-BF-A3DJ	SKCM	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation altering degron motif	0.6752
p.P401S	TCGA-EE-A29T	SKCM	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation altering degron motif	0.6752
p.P401S	DO37742	SKCM	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation altering degron motif	0.6752
p.P401S	DO51237	SKCM	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation altering degron motif	0.6752
p.P401S	DO52402	UCEC	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation altering degron motif	0.6752
p.H258N	TCGA-BR-4357	STAD	TCGA	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2778
p.H258N	DO38241	STAD	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2778
p.E794D	TCGA-BR-4361	STAD	TCGA	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.2222
p.E794D	TCGA-BR-6453	STAD	TCGA	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.2222
p.E794D	DO233673	GACA	ICGC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.2222
p.E794D	DO38887	STAD	ICGC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.2222
p.E794D	DO38543	STAD	ICGC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.2222
p.I411M	TCGA-BR-8680	STAD	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation altering degron motif	0.6507
p.I411M	DO47769	STAD	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation altering degron motif	0.6507
p.F417L	TCGA-BS-A0TC	UCEC	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation rewiring degron network	0.1667
p.F417L	DO42400	UCEC	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation rewiring degron network	0.1667
p.Q421E	TCGA-BS-A0UV	UCEC	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation rewiring degron network	0.0556
p.Q421E	DO42793	UCEC	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation rewiring degron network	0.0556
p.T1141N	TCGA-CN-4727	HNSC	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation altering degron motif	0.5944
p.T1141N	DO14258	HNSC	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation altering degron motif	0.5944
p.P1037L	TCGA-CN-6992	HNSC	TCGA	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.3056
p.P1037L	DO14606	HNSC	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.3056
p.T410N	TCGA-CQ-5327	HNSC	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation altering degron motif	0.5944
p.T410N	DO15878	HNSC	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation altering degron motif	0.5944
p.G243R	TCGA-D3-A2JH	SKCM	TCGA	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2222
p.G243R	DO47263	SKCM	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2222
p.E794K	TCGA-D3-A8GI	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.2222
p.E794K	DO220885	MELA	ICGC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.2222
p.E794K	DO50284	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.2222
p.S1133F	TCGA-D3-A8GL	SKCM	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1667
p.S1133F	TCGA-FW-A3R5	SKCM	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1667
p.S1133F	DO37406	SKCM	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1667
p.S1133F	DO50287	SKCM	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1667
p.R248S	TCGA-D5-6926	COAD	TCGA	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation altering degron motif	0.6316
p.R248S	DO8530	COAD	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation altering degron motif	0.6316
p.R248S	DO230950	LUSC	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation altering degron motif	0.6316
p.R248S	DO224638	LUSC	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation altering degron motif	0.6316
p.D1042Y	TCGA-D6-8569	HNSC	TCGA	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.1667
p.D1042Y	TCGA-NC-A5HK	LUSC	TCGA	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.1667
p.D1042Y	DO14454	HNSC	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.1667
p.D1042Y	DO219191	LUSC	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.1667
p.G1014D	TCGA-D7-5578	STAD	TCGA	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.0556
p.G1014D	DO38475	STAD	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.0556
p.H790Y	TCGA-D9-A6EC	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.1111
p.H790Y	TCGA-EE-A3JB	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.1111
p.H790Y	DO50291	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.1111
p.H790Y	DO51250	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.1111
p.H258R	TCGA-DD-A73C	LIHC	TCGA	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2778
p.H258R	DO50991	LAML	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2778
p.H258R	DO48593	LIHC	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2778
p.V1018E	TCGA-DD-AADF	LIHC	TCGA	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.1667
p.V1018E	DO52232	LIHC	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.1667
p.A240T	TCGA-DF-A2KZ	UCEC	TCGA	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.1389
p.A240T	DO52409	UCEC	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.1389
p.F1131Y	TCGA-DX-AB2X	SARC	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1111
p.F1131Y	DO220096	SARC	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1111
p.G1152E	TCGA-EE-A29V	SKCM	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1944
p.G1152E	DO222363	MELA	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1944
p.G1152E	DO38006	SKCM	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1944
p.G245E	TCGA-EO-A3B0	UCEC	TCGA	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2778
p.G245E	DO219773	UCEC	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2778
p.A1025T	TCGA-ER-A199	SKCM	TCGA	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation altering degron motif	0.7139
p.A1025T	DO47395	SKCM	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation altering degron motif	0.7139
p.A1033E	TCGA-EY-A5W2	UCEC	TCGA	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation altering degron motif	0.659
p.A1033E	DO48177	UCEC	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation altering degron motif	0.659
p.P798A	TCGA-FI-A3PX	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation altering degron motif	0.6392
p.P798A	DO52417	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation altering degron motif	0.6392
p.L1132F	TCGA-FR-A8YC	SKCM	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1389
p.L1132F	TCGA-GN-A266	SKCM	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1389
p.L1132F	DO220903	MELA	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1389
p.L1132F	DO37432	SKCM	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1389
p.L1132F	DO50301	SKCM	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1389
p.G245R	TCGA-FS-A1ZA	SKCM	TCGA	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2778
p.G245R	DO37551	SKCM	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2778
p.R248K	TCGA-FW-A3R5	SKCM	TCGA	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation altering degron motif	0.6126
p.R248K	DO37406	SKCM	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation altering degron motif	0.6126
p.V803G	TCGA-GC-A6I1	BLCA	TCGA	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.3056
p.V803G	DO49770	BLCA	ICGC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.3056
p.A804T	TCGA-HU-8602	STAD	TCGA	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.2778
p.A804T	DO47829	STAD	ICGC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.2778
p.T801N	TCGA-KK-A7B0	PRAD	TCGA	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation altering degron motif	0.8166
p.T801N	DO219307	PRAD	ICGC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation altering degron motif	0.8166
p.S250R	TCGA-L5-A8NE	ESCA	TCGA	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation altering degron motif	0.7427
p.Q1129H	TCGA-NC-A5HN	LUSC	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.0556
p.Q1129H	DO52025	LUSC	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.0556
p.P1136A	TCGA-NC-A5HT	LUSC	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.25
p.P1136A	DO219205	LUSC	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.25
p.E405K	TCGA-WE-A8ZX	SKCM	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation altering degron motif	0.591
p.E405K	DO51291	SKCM	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation altering degron motif	0.591
p.P264S	TCGA-WE-AAA0	SKCM	TCGA	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.1111
p.P264S	DO51294	SKCM	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.1111
p.G243E	TCGA-YD-A89C	SKCM	TCGA	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2222
p.G243E	DO219501	SKCM	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2222
p.G243E	SIDM01161	Other Sarcomas	GDSC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2222
p.G243E	SIDM00136	Colorectal Carcinoma	GDSC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2222
p.G243E	ACH-000552	Colon/Colorectal Cancer	CCLE	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2222
p.G243E	ACH-001274	Sarcoma	CCLE	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2222
p.G243E	ACH-001524	Skin Cancer	CCLE	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2222
p.G243E	SW982	soft tissue	COSMIC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2222
p.G243E	HT-29	large intestine	COSMIC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.2222
p.P1144T	DO1158	BRCA	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation altering degron motif	0.5919
p.F252C	DO222798	COCA	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation altering degron motif	0.5996
p.Q261L	DO229010	COCA	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.1944
p.Q261L	DO229013	COCA	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.1944
p.Q261L	DO229016	COCA	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.1944
p.Q261L	DO229003	COCA	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.1944
p.Q261L	DO229005	COCA	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.1944
p.N403H	DO10858	ESAD	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation altering degron motif	0.6312
p.N403H	DO233642	GACA	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation altering degron motif	0.6312
p.F1017C	DO234189	ESAD	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.1389
p.L1034V	DO234426	ESAD	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation altering degron motif	0.5654
p.S262C	DO222500	ESCA	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.1667
p.L796V	DO233192	GACA	ICGC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.2778
p.G1014C	DO233636	GACA	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.0556
p.A1020V	DO233797	GACA	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.2222
p.S247I	DO229018	LICA	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation altering degron motif	0.7341
p.V253F	DO229019	LICA	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation altering degron motif	0.7068
p.V242L	DO230931	LUSC	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.1944
p.V242L	DO224548	LUSC	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.1944
p.L1155F	DO222363	MELA	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1111
p.Q1134K	DO46478	OV	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1944
p.N1046Y	DO49136	PACA	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.0556
p.V407D	DO32916	PACA	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation altering degron motif	0.6674
p.V407D	SIDM00957	Colorectal Carcinoma	GDSC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation altering degron motif	0.6674
p.V407D	COLO-678	large intestine	COSMIC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation altering degron motif	0.6674
p.A1033V	DO35083	PACA	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation altering degron motif	0.5825
p.K419E	DO233509	PRAD	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation substituting flanking lysine	0.2222
p.S241P	DO46853	RECA	ICGC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation blocking phosphorylation signal	0.6111
p.G395S	DO219878	SKCA	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	399:411	Mutation rewiring degron network	0.2222
p.V253A	SIDM02059	Colorectal Carcinoma	GDSC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation altering degron motif	0.6936
p.K809R	SIDM01078	Small Cell Lung Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation substituting flanking lysine	0.25
p.K809R	ACH-000790	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation substituting flanking lysine	0.25
p.K809R	SHP-77	lung	COSMIC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation substituting flanking lysine	0.25
p.K807Q	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation substituting flanking lysine	0.3056
p.Q1022K	SIDM00230	Small Cell Lung Carcinoma	GDSC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.2778
p.Q1022K	ACH-002145	Lung Cancer	CCLE	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.2778
p.Q1022K	IST-SL2	lung	COSMIC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.2778
p.I1036M	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation altering degron motif	0.6507
p.I1036M	ACH-000841	Lung Cancer	CCLE	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation altering degron motif	0.6507
p.I1036M	NCI-H2087	lung	COSMIC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation altering degron motif	0.6507
p.K1043N	SIDM00282	Colorectal Carcinoma	GDSC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation substituting flanking lysine	0.25
p.K1043N	ACH-000998	Colon/Colorectal Cancer	CCLE	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation substituting flanking lysine	0.25
p.K1043N	CW-2	large intestine	COSMIC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation substituting flanking lysine	0.25
p.T1019K	SIDM00100	Mesothelioma	GDSC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.1944
p.T1019K	ACH-002127	Lung Cancer	CCLE	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.1944
p.T1019K	H2595	pleura	COSMIC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation rewiring degron network	0.1944
p.A804V	SIDM01611	Endometrial Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.2778
p.A804V	ACH-000996	Endometrial/Uterine Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.2778
p.P1136S	SIDM01561	Melanoma	GDSC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.25
p.P1136S	ACH-000799	Skin Cancer	CCLE	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.25
p.R812Q	SIDM01750	Melanoma	GDSC	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.0556
p.R812Q	ACH-000801	Skin Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.0556
p.S247R	ACH-000360	Colon/Colorectal Cancer	CCLE	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation altering degron motif	0.7427
p.P798S	ACH-000712	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation altering degron motif	0.6752
p.G1149A	ACH-001197	Lymphoma	CCLE	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.2778
p.T801P	ACH-001645	Skin Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	798:802	Mutation altering degron motif	0.8142
p.F1131L	ACH-001834	Bile Duct Cancer	CCLE	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1111
p.K249T	ACH-001991	Primary	CCLE	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation altering degron motif	0.6195
p.H1043Q	DU-145	prostate	COSMIC	LAPLALPEQALLI	DEG_ODPH_VHL_1	1024:1036	Mutation substituting flanking lysine	0.25
p.C1156F	D-502MG	central nervous system	COSMIC	TRTSLPQLS	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.0833
p.A237V	SNU-C2B	large intestine	COSMIC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation blocking phosphorylation signal	0.5
p.I250M	LNCaP-Clone-FGC	prostate	COSMIC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation altering degron motif	0.7618
p.G265D	HEC-1	endometrium	COSMIC	SRKSRFVPSA	DEG_COP1_1	247:256	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF804A

UniProt ID: Q7Z570

Entrez ID: 91752

Protein name: Zinc finger protein 804A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF804A in