DegronMD

Uniprot ID: Q7Z570

Source protein: Zinc finger protein 804A

Source gene: ZNF804A

Class: DEG_APCC_DBOX_1

Location: 1139:1147

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9816

ASA_SCORE: 82.0444

COIL: 0.9264

CONS_SCORE: 0.4595

DSS_SCORE: 0.3338

HELIX: 0.0274

FCONS_SCORE: 0.942

RIG_SCORE: 0.7251

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1129K	TCGA-33-4533	LUSC	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	0.0556
p.Q1129K	DO27572	LUSC	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.0556
p.Q1130K	TCGA-38-4625	LUAD	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	0.0833
p.Q1130K	DO23952	LUAD	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.0833
p.R1154S	TCGA-43-7658	LUSC	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	0.1389
p.R1154S	DO27628	LUSC	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.1389
p.R1154M	TCGA-44-A479	LUAD	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	0.1389
p.R1154M	DO23633	LUAD	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.1389
p.P1136T	TCGA-55-A4DG	LUAD	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	0.25
p.P1136T	DO26337	LUAD	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.25
p.P1157H	TCGA-63-7021	LUSC	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	0.0556
p.P1157H	DO26782	LUSC	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.0556
p.L1138I	TCGA-85-A4JB	LUSC	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	0.3056
p.L1138I	DO45517	LUSC	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.3056
p.L1132I	TCGA-AZ-4315	COAD	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	0.1389
p.L1132I	TCGA-B5-A0JY	UCEC	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	0.1389
p.L1132I	DO8842	COAD	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.1389
p.L1132I	DO43041	UCEC	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.1389
p.T1141N	TCGA-CN-4727	HNSC	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	0.5944
p.T1141N	DO14258	HNSC	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.5944
p.S1133F	TCGA-D3-A8GL	SKCM	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	0.1667
p.S1133F	TCGA-FW-A3R5	SKCM	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	0.1667
p.S1133F	DO37406	SKCM	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.1667
p.S1133F	DO50287	SKCM	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.1667
p.F1131Y	TCGA-DX-AB2X	SARC	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	0.1111
p.F1131Y	DO220096	SARC	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.1111
p.G1152E	TCGA-EE-A29V	SKCM	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	0.1944
p.G1152E	DO222363	MELA	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.1944
p.G1152E	DO38006	SKCM	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.1944
p.L1132F	TCGA-FR-A8YC	SKCM	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	0.1389
p.L1132F	TCGA-GN-A266	SKCM	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	0.1389
p.L1132F	DO220903	MELA	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.1389
p.L1132F	DO37432	SKCM	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.1389
p.L1132F	DO50301	SKCM	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.1389
p.Q1129H	TCGA-NC-A5HN	LUSC	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	0.0556
p.Q1129H	DO52025	LUSC	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.0556
p.P1136A	TCGA-NC-A5HT	LUSC	TCGA	TRTSLPQLS	DEG_APCC_DBOX_1	0.25
p.P1136A	DO219205	LUSC	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.25
p.P1144T	DO1158	BRCA	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.5919
p.L1155F	DO222363	MELA	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.1111
p.Q1134K	DO46478	OV	ICGC	TRTSLPQLS	DEG_APCC_DBOX_1	0.1944
p.P1136S	SIDM01561	Melanoma	GDSC	TRTSLPQLS	DEG_APCC_DBOX_1	0.25
p.P1136S	ACH-000799	Skin Cancer	CCLE	TRTSLPQLS	DEG_APCC_DBOX_1	0.25
p.G1149A	ACH-001197	Lymphoma	CCLE	TRTSLPQLS	DEG_APCC_DBOX_1	0.2778
p.F1131L	ACH-001834	Bile Duct Cancer	CCLE	TRTSLPQLS	DEG_APCC_DBOX_1	0.1111
p.C1156F	D-502MG	central_nervous_system	COSMIC	TRTSLPQLS	DEG_APCC_DBOX_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRTSLPQLS

Degron related mutations and impact score

Drug responses associated with ZNF804A mutations

All proteins holding degron of TRTSLPQLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z570	Zinc finger protein 804A	DEG_APCC_DBOX_1	1139:1147	TRTSLPQLS	APC,CDC20,FZR1	0.9816	More...