DegronMD

Uniprot ID: Q7Z570

Source protein: Zinc finger protein 804A

Source gene: ZNF804A

Class: DEG_COP1_1

Location: 247:256

E3 ligase: COP1

DEGRON score: 0.9967

ASA_SCORE: 91.98

COIL: 0.7354

CONS_SCORE: 0.6536

DSS_SCORE: 0.3783

HELIX: 0.1451

FCONS_SCORE: 1.2364

RIG_SCORE: 0.7149

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R251I	TCGA-05-4382	LUAD	TCGA	SRKSRFVPSA	DEG_COP1_1	0.6991
p.R251I	DO24900	LUAD	ICGC	SRKSRFVPSA	DEG_COP1_1	0.6991
p.R251I	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	SRKSRFVPSA	DEG_COP1_1	0.6991
p.R251I	ACH-000562	Lung Cancer	CCLE	SRKSRFVPSA	DEG_COP1_1	0.6991
p.R251I	HCC-78	lung	COSMIC	SRKSRFVPSA	DEG_COP1_1	0.6991
p.H258Y	TCGA-49-AAR9	LUAD	TCGA	SRKSRFVPSA	DEG_COP1_1	0.2778
p.H258Y	DO218921	LUAD	ICGC	SRKSRFVPSA	DEG_COP1_1	0.2778
p.G245V	TCGA-55-8507	LUAD	TCGA	SRKSRFVPSA	DEG_COP1_1	0.2778
p.G245V	DO45412	LUAD	ICGC	SRKSRFVPSA	DEG_COP1_1	0.2778
p.R251G	TCGA-56-A5DS	LUSC	TCGA	SRKSRFVPSA	DEG_COP1_1	0.6457
p.R251G	DO45494	LUSC	ICGC	SRKSRFVPSA	DEG_COP1_1	0.6457
p.A240S	TCGA-85-8276	LUSC	TCGA	SRKSRFVPSA	DEG_COP1_1	0.1389
p.A240S	DO26436	LUSC	ICGC	SRKSRFVPSA	DEG_COP1_1	0.1389
p.S262F	TCGA-A5-A0G2	UCEC	TCGA	SRKSRFVPSA	DEG_COP1_1	0.1667
p.S262F	DO41235	UCEC	ICGC	SRKSRFVPSA	DEG_COP1_1	0.1667
p.H258N	TCGA-BR-4357	STAD	TCGA	SRKSRFVPSA	DEG_COP1_1	0.2778
p.H258N	DO38241	STAD	ICGC	SRKSRFVPSA	DEG_COP1_1	0.2778
p.G243R	TCGA-D3-A2JH	SKCM	TCGA	SRKSRFVPSA	DEG_COP1_1	0.2222
p.G243R	DO47263	SKCM	ICGC	SRKSRFVPSA	DEG_COP1_1	0.2222
p.R248S	TCGA-D5-6926	COAD	TCGA	SRKSRFVPSA	DEG_COP1_1	0.6316
p.R248S	DO8530	COAD	ICGC	SRKSRFVPSA	DEG_COP1_1	0.6316
p.R248S	DO230950	LUSC	ICGC	SRKSRFVPSA	DEG_COP1_1	0.6316
p.R248S	DO224638	LUSC	ICGC	SRKSRFVPSA	DEG_COP1_1	0.6316
p.H258R	TCGA-DD-A73C	LIHC	TCGA	SRKSRFVPSA	DEG_COP1_1	0.2778
p.H258R	DO50991	LAML	ICGC	SRKSRFVPSA	DEG_COP1_1	0.2778
p.H258R	DO48593	LIHC	ICGC	SRKSRFVPSA	DEG_COP1_1	0.2778
p.A240T	TCGA-DF-A2KZ	UCEC	TCGA	SRKSRFVPSA	DEG_COP1_1	0.1389
p.A240T	DO52409	UCEC	ICGC	SRKSRFVPSA	DEG_COP1_1	0.1389
p.G245E	TCGA-EO-A3B0	UCEC	TCGA	SRKSRFVPSA	DEG_COP1_1	0.2778
p.G245E	DO219773	UCEC	ICGC	SRKSRFVPSA	DEG_COP1_1	0.2778
p.G245R	TCGA-FS-A1ZA	SKCM	TCGA	SRKSRFVPSA	DEG_COP1_1	0.2778
p.G245R	DO37551	SKCM	ICGC	SRKSRFVPSA	DEG_COP1_1	0.2778
p.R248K	TCGA-FW-A3R5	SKCM	TCGA	SRKSRFVPSA	DEG_COP1_1	0.6126
p.R248K	DO37406	SKCM	ICGC	SRKSRFVPSA	DEG_COP1_1	0.6126
p.S250R	TCGA-L5-A8NE	ESCA	TCGA	SRKSRFVPSA	DEG_COP1_1	0.7427
p.P264S	TCGA-WE-AAA0	SKCM	TCGA	SRKSRFVPSA	DEG_COP1_1	0.1111
p.P264S	DO51294	SKCM	ICGC	SRKSRFVPSA	DEG_COP1_1	0.1111
p.G243E	TCGA-YD-A89C	SKCM	TCGA	SRKSRFVPSA	DEG_COP1_1	0.2222
p.G243E	DO219501	SKCM	ICGC	SRKSRFVPSA	DEG_COP1_1	0.2222
p.G243E	SIDM01161	Other Sarcomas	GDSC	SRKSRFVPSA	DEG_COP1_1	0.2222
p.G243E	SIDM00136	Colorectal Carcinoma	GDSC	SRKSRFVPSA	DEG_COP1_1	0.2222
p.G243E	ACH-000552	Colon/Colorectal Cancer	CCLE	SRKSRFVPSA	DEG_COP1_1	0.2222
p.G243E	ACH-001274	Sarcoma	CCLE	SRKSRFVPSA	DEG_COP1_1	0.2222
p.G243E	ACH-001524	Skin Cancer	CCLE	SRKSRFVPSA	DEG_COP1_1	0.2222
p.G243E	SW982	soft_tissue	COSMIC	SRKSRFVPSA	DEG_COP1_1	0.2222
p.G243E	HT-29	large_intestine	COSMIC	SRKSRFVPSA	DEG_COP1_1	0.2222
p.F252C	DO222798	COCA	ICGC	SRKSRFVPSA	DEG_COP1_1	0.5996
p.Q261L	DO229010	COCA	ICGC	SRKSRFVPSA	DEG_COP1_1	0.1944
p.Q261L	DO229013	COCA	ICGC	SRKSRFVPSA	DEG_COP1_1	0.1944
p.Q261L	DO229016	COCA	ICGC	SRKSRFVPSA	DEG_COP1_1	0.1944
p.Q261L	DO229003	COCA	ICGC	SRKSRFVPSA	DEG_COP1_1	0.1944
p.Q261L	DO229005	COCA	ICGC	SRKSRFVPSA	DEG_COP1_1	0.1944
p.S262C	DO222500	ESCA	ICGC	SRKSRFVPSA	DEG_COP1_1	0.1667
p.S247I	DO229018	LICA	ICGC	SRKSRFVPSA	DEG_COP1_1	0.7341
p.V253F	DO229019	LICA	ICGC	SRKSRFVPSA	DEG_COP1_1	0.7068
p.V242L	DO230931	LUSC	ICGC	SRKSRFVPSA	DEG_COP1_1	0.1944
p.V242L	DO224548	LUSC	ICGC	SRKSRFVPSA	DEG_COP1_1	0.1944
p.S241P	DO46853	RECA	ICGC	SRKSRFVPSA	DEG_COP1_1	0.6111
p.V253A	SIDM02059	Colorectal Carcinoma	GDSC	SRKSRFVPSA	DEG_COP1_1	0.6936
p.S247R	ACH-000360	Colon/Colorectal Cancer	CCLE	SRKSRFVPSA	DEG_COP1_1	0.7427
p.K249T	ACH-001991	Primary	CCLE	SRKSRFVPSA	DEG_COP1_1	0.6195
p.A237V	SNU-C2B	large_intestine	COSMIC	SRKSRFVPSA	DEG_COP1_1	0.5
p.I250M	LNCaP-Clone-FGC	prostate	COSMIC	SRKSRFVPSA	DEG_COP1_1	0.7618
p.G265D	HEC-1	endometrium	COSMIC	SRKSRFVPSA	DEG_COP1_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRKSRFVPSA

Degron related mutations and impact score

Drug responses associated with ZNF804A mutations

All proteins holding degron of SRKSRFVPSA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z570	Zinc finger protein 804A	DEG_COP1_1	247:256	SRKSRFVPSA	COP1	0.9967	More...