DegronMD

Uniprot ID: Q7Z570

Source protein: Zinc finger protein 804A

Source gene: ZNF804A

Class: DEG_SPOP_SBC_1

Location: 798:802

E3 ligase: SPOP

DEGRON score: 0.9948

ASA_SCORE: 87.24

COIL: 0.953

CONS_SCORE: 0.3371

DSS_SCORE: 0.6163

HELIX: 0.03

FCONS_SCORE: 0.8394

RIG_SCORE: 0.6208

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R797K	TCGA-02-2485	GBM	TCGA	PPSTS	DEG_SPOP_SBC_1	0.3056
p.R797K	DO12742	GBM	ICGC	PPSTS	DEG_SPOP_SBC_1	0.3056
p.A804S	TCGA-17-Z049	LUAD	TCGA	PPSTS	DEG_SPOP_SBC_1	0.2778
p.P808L	TCGA-44-6777	LUAD	TCGA	PPSTS	DEG_SPOP_SBC_1	0.1667
p.P808L	DO23645	LUAD	ICGC	PPSTS	DEG_SPOP_SBC_1	0.1667
p.R812W	TCGA-A5-A0G2	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.0556
p.R812W	TCGA-VQ-A8P2	STAD	TCGA	PPSTS	DEG_SPOP_SBC_1	0.0556
p.R812W	DO34112	PACA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.0556
p.R812W	DO51761	STAD	ICGC	PPSTS	DEG_SPOP_SBC_1	0.0556
p.R812W	DO41235	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.0556
p.R812W	SIDM01293	Colorectal Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.0556
p.F795L	TCGA-AP-A056	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.25
p.F795L	DO50345	ESAD	ICGC	PPSTS	DEG_SPOP_SBC_1	0.25
p.F795L	DO43971	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.25
p.T801I	TCGA-AX-A2HD	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.8189
p.T801I	DO42608	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.8189
p.E794D	TCGA-BR-4361	STAD	TCGA	PPSTS	DEG_SPOP_SBC_1	0.2222
p.E794D	TCGA-BR-6453	STAD	TCGA	PPSTS	DEG_SPOP_SBC_1	0.2222
p.E794D	DO233673	GACA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.2222
p.E794D	DO38887	STAD	ICGC	PPSTS	DEG_SPOP_SBC_1	0.2222
p.E794D	DO38543	STAD	ICGC	PPSTS	DEG_SPOP_SBC_1	0.2222
p.E794K	TCGA-D3-A8GI	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	0.2222
p.E794K	DO220885	MELA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.2222
p.E794K	DO50284	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	0.2222
p.H790Y	TCGA-D9-A6EC	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	0.1111
p.H790Y	TCGA-EE-A3JB	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	0.1111
p.H790Y	DO50291	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	0.1111
p.H790Y	DO51250	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	0.1111
p.P798A	TCGA-FI-A3PX	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.6392
p.P798A	DO52417	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.6392
p.V803G	TCGA-GC-A6I1	BLCA	TCGA	PPSTS	DEG_SPOP_SBC_1	0.3056
p.V803G	DO49770	BLCA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.3056
p.A804T	TCGA-HU-8602	STAD	TCGA	PPSTS	DEG_SPOP_SBC_1	0.2778
p.A804T	DO47829	STAD	ICGC	PPSTS	DEG_SPOP_SBC_1	0.2778
p.T801N	TCGA-KK-A7B0	PRAD	TCGA	PPSTS	DEG_SPOP_SBC_1	0.8166
p.T801N	DO219307	PRAD	ICGC	PPSTS	DEG_SPOP_SBC_1	0.8166
p.L796V	DO233192	GACA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.2778
p.K809R	SIDM01078	Small Cell Lung Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.25
p.K809R	ACH-000790	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	0.25
p.K809R	SHP-77	lung	COSMIC	PPSTS	DEG_SPOP_SBC_1	0.25
p.K807Q	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.3056
p.A804V	SIDM01611	Endometrial Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.2778
p.A804V	ACH-000996	Endometrial/Uterine Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	0.2778
p.R812Q	SIDM01750	Melanoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.0556
p.R812Q	ACH-000801	Skin Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	0.0556
p.P798S	ACH-000712	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	0.6752
p.T801P	ACH-001645	Skin Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	0.8142

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00160	Unconventional myosin-If	DEG_SPOP_SBC_1	984:988	PPSTS	SPOP	0.9842	More...
O14746	Telomerase reverse transcriptase	DEG_SPOP_SBC_1	307:311	PPSTS	SPOP	0.9923	More...
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	904:908	PPSTS	SPOP	0.8193	More...
O43516	WAS/WASL-interacting protein family member 1	DEG_SPOP_SBC_1	432:436	PPSTS	SPOP	0.9568	More...
O43526	Potassium voltage-gated channel subfamily KQT member 2	DEG_SPOP_SBC_1	713:717	PPSTS	SPOP	0.8569	More...
O60312	Phospholipid-transporting ATPase VA	DEG_SPOP_SBC_1	959:963	PPSTS	SPOP	0.8225	More...
O75175	CCR4-NOT transcription complex subunit 3	DEG_SPOP_SBC_1	465:469	PPSTS	SPOP	0.8566	More...
O94933	SLIT and NTRK-like protein 3	DEG_SPOP_SBC_1	344:348	PPSTS	SPOP	0.5069	More...
P16150	Leukosialin	DEG_SPOP_SBC_1	66:70	PPSTS	SPOP	0.9993	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	577:581	PPSTS	SPOP	0.9911	More...
Q09472	Histone acetyltransferase p300	DEG_SPOP_SBC_1	954:958	PPSTS	SPOP	0.9959	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	84:88	PPSTS	SPOP	0.9962	More...
Q13207	T-box transcription factor TBX2	DEG_SPOP_SBC_1	631:635	PPSTS	SPOP	0.9985	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1374:1378	PPSTS	SPOP	0.9728	More...
Q14938	Nuclear factor 1 X-type	DEG_SPOP_SBC_1	269:273	PPSTS	SPOP	0.9824	More...
Q7Z570	Zinc finger protein 804A	DEG_SPOP_SBC_1	798:802	PPSTS	SPOP	0.9948	More...
Q7Z7A4	PX domain-containing protein kinase-like protein	DEG_SPOP_SBC_1	505:509	PPSTS	SPOP	0.794	More...
Q86TM6	E3 ubiquitin-protein ligase synoviolin	DEG_SPOP_SBC_1	406:410	PPSTS	SPOP	0.9932	More...
Q92918	Mitogen-activated protein kinase kinase kinase kinase 1	DEG_SPOP_SBC_1	442:446	PPSTS	SPOP	0.9477	More...
Q9BQ89	Protein FAM110A	DEG_SPOP_SBC_1	145:149	PPSTS	SPOP	0.8404	More...
Q9NS91	E3 ubiquitin-protein ligase RAD18	DEG_SPOP_SBC_1	190:194	PPSTS	SPOP	0.91	More...
Q9NYQ6	Cadherin EGF LAG seven-pass G-type receptor 1	DEG_SPOP_SBC_1	906:910	PPSTS	SPOP	0.9655	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SPOP_SBC_1	765:769	PPSTS	SPOP	0.9907	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	419:423	PPSTS	SPOP	0.9758	More...
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SPOP_SBC_1	742:746	PPSTS	SPOP	0.9525	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	1755:1759	PPSTS	SPOP	0.9881	More...
Q96M27	Protein PRRC1	DEG_SPOP_SBC_1	111:115	PPSTS	SPOP	0.9952	More...
Q5T8I3	Protein FAM102B	DEG_SPOP_SBC_1	152:156	PPSTS	SPOP	0.978	More...
Q96KW2	POM121-like protein 2	DEG_SPOP_SBC_1	130:134	PPSTS	SPOP	0.5646	More...
Q96KW2	POM121-like protein 2	DEG_SPOP_SBC_1	483:487	PPSTS	SPOP	0.9614	More...
Q8IXP5	Uncharacterized protein C11orf53	DEG_SPOP_SBC_1	130:134	PPSTS	SPOP	0.9669	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSTS

Degron related mutations and impact score

Drug responses associated with ZNF804A mutations

All proteins holding degron of PPSTS