DegronMD - P16150(SPN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S144I	TCGA-77-A5G6	LUSC	TCGA	PETSS	DEG_SPOP_SBC_1	140:144	Mutation altering degron motif	0.7341
p.S144I	DO50097	LUSC	ICGC	PETSS	DEG_SPOP_SBC_1	140:144	Mutation altering degron motif	0.7341
p.P248T	TCGA-A5-A0GB	UCEC	TCGA	PTTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.0556
p.P248T	DO41434	UCEC	ICGC	PTTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.0556
p.L77H	TCGA-A6-5661	COAD	TCGA	PPSTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1389
p.L77H	DO8634	COAD	ICGC	PPSTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1389
p.P140L	TCGA-AD-6895	COAD	TCGA	PETSS	DEG_SPOP_SBC_1	140:144	Mutation altering degron motif	0.7582
p.P140L	DO8938	COAD	ICGC	PETSS	DEG_SPOP_SBC_1	140:144	Mutation altering degron motif	0.7582
p.R246W	TCGA-CA-6717	COAD	TCGA	PTTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1111
p.R246W	DO8264	COAD	ICGC	PTTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1111
p.R246Q	TCGA-DX-A2IZ	SARC	TCGA	PTTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1111
p.R246Q	TCGA-NH-A5IV	COAD	TCGA	PTTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1111
p.R246Q	DO49095	COAD	ICGC	PTTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1111
p.R246Q	DO219961	SARC	ICGC	PTTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1111
p.A122E	TCGA-E7-A7PW	BLCA	TCGA	PQETPHAT	DEG_SCF_FBW7_1	106:113	Mutation rewiring degron network	0.0833
p.A122E	DO219017	BLCA	ICGC	PQETPHAT	DEG_SCF_FBW7_1	106:113	Mutation rewiring degron network	0.0833
p.S80F	TCGA-EE-A29L	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0556
p.S80F	DO222599	MELA	ICGC	PPSTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0556
p.S80F	DO37835	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0556
p.D60N	TCGA-EE-A3AG	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1667
p.D60N	DO37471	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1667
p.S99F	TCGA-EE-A3AG	SKCM	TCGA	PQETPHAT	DEG_SCF_FBW7_1	106:113	Mutation rewiring degron network	0.1389
p.S99F	DO37471	SKCM	ICGC	PQETPHAT	DEG_SCF_FBW7_1	106:113	Mutation rewiring degron network	0.1389
p.P110L	TCGA-EO-A22U	UCEC	TCGA	PQETPHAT	DEG_SCF_FBW7_1	106:113	Mutation altering degron motif	0.7582
p.P110L	DO43755	UCEC	ICGC	PQETPHAT	DEG_SCF_FBW7_1	106:113	Mutation altering degron motif	0.7582
p.S147N	TCGA-XK-AAIW	PRAD	TCGA	PETSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.25
p.S147N	DO51407	PRAD	ICGC	PETSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.25
p.S224F	DO225215	BRCA	ICGC	PTTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.0556
p.S224F	DO227836	BRCA	ICGC	PTTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.0556
p.G132C	DO228935	COCA	ICGC	PETSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.1111
p.S225R	DO234285	ESAD	ICGC	PTTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.0833
p.S225R	SIDM00455	Pancreatic Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.0833
p.S225R	SIDM00884	Breast Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.0833
p.S225R	SIDM00885	Breast Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.0833
p.S225R	SIDM00869	Non-Cancerous	GDSC	PTTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.0833
p.S225R	SIDM00522	Small Cell Lung Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.0833
p.S225R	SIDM00883	Non-Cancerous	GDSC	PTTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.0833
p.S139F	DO222446	ESCA	ICGC	PETSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.3056
p.T153M	DO233652	GACA	ICGC	PETSS	DEG_SPOP_SBC_1	140:144	Mutation blocking phosphorylation signal	0.5278
p.V226L	DO228971	LICA	ICGC	PTTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1111
p.M102I	DO229045	LICA	ICGC	PQETPHAT	DEG_SCF_FBW7_1	106:113	Mutation rewiring degron network	0.2222
p.N239S	DO50889	LICA	ICGC	PTTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.3056
p.A154T	DO229456	SKCA	ICGC	PETSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.0556
p.G59R	SIDM00126	Melanoma	GDSC	PPSTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1389
p.G59R	ACH-002147	Skin Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1389
p.G59R	K2	skin	COSMIC	PPSTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1389
p.G59E	SIDM00126	Melanoma	GDSC	PPSTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1389
p.G59E	ACH-002147	Skin Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1389
p.G59E	K2	skin	COSMIC	PPSTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1389
p.T62N	SIDM00927	Small Cell Lung Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.2222
p.T62N	ACH-000871	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.2222
p.T62N	NCI-H510A	lung	COSMIC	PPSTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.2222
p.V118L	SIDM01727	Chronic Myelogenous Leukemia	GDSC	PQETPHAT	DEG_SCF_FBW7_1	106:113	Mutation rewiring degron network	0.1944
p.V118L	ACH-000241	Leukemia	CCLE	PQETPHAT	DEG_SCF_FBW7_1	106:113	Mutation rewiring degron network	0.1944
p.T137M	ACH-000208	Brain Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.25
p.T142P	ACH-000956	Prostate Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	140:144	Mutation altering degron motif	0.7031
p.T142P	22RV1	prostate	COSMIC	PETSS	DEG_SPOP_SBC_1	140:144	Mutation altering degron motif	0.7031

Kaplan plot for SPN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPN

UniProt ID: P16150

Entrez ID: 6693

Protein name: Leukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPN in