DegronMD

Uniprot ID: P16150

Source protein: Leukosialin

Source gene: SPN

Class: DEG_SCF_FBW7_1

Location: 106:113

E3 ligase: FBXW7

DEGRON score: 0.9689

ASA_SCORE: 99.4375

COIL: 0.9294

CONS_SCORE: 0.5227

DSS_SCORE: 0.6359

HELIX: 0.0272

FCONS_SCORE: 1.0224

RIG_SCORE: 0.6274

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A122E	TCGA-E7-A7PW	BLCA	TCGA	PQETPHAT	DEG_SCF_FBW7_1	0.0833
p.A122E	DO219017	BLCA	ICGC	PQETPHAT	DEG_SCF_FBW7_1	0.0833
p.S99F	TCGA-EE-A3AG	SKCM	TCGA	PQETPHAT	DEG_SCF_FBW7_1	0.1389
p.S99F	DO37471	SKCM	ICGC	PQETPHAT	DEG_SCF_FBW7_1	0.1389
p.P110L	TCGA-EO-A22U	UCEC	TCGA	PQETPHAT	DEG_SCF_FBW7_1	0.7582
p.P110L	DO43755	UCEC	ICGC	PQETPHAT	DEG_SCF_FBW7_1	0.7582
p.M102I	DO229045	LICA	ICGC	PQETPHAT	DEG_SCF_FBW7_1	0.2222
p.V118L	SIDM01727	Chronic Myelogenous Leukemia	GDSC	PQETPHAT	DEG_SCF_FBW7_1	0.1944
p.V118L	ACH-000241	Leukemia	CCLE	PQETPHAT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16150	Leukosialin	DEG_SCF_FBW7_1	106:113	PQETPHAT	FBXW7	0.9689	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons